侯一平
法医遗传学及法医分子生物学研究
个性化签名
- 姓名:侯一平
- 目前身份:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
法医学
- 研究兴趣:法医遗传学及法医分子生物学研究
侯一平教授,从事法医遗传学及法医分子生物学研究。1978-1983华西医科大学,医学本科生,医学学士。1985-1988华西医科大学,法医遗传学研究生,医学硕士。1992-1993德国科隆大学, 法医遗传学,访问学者。1995-1996德国不来梅大学,人类遗传学,德国洪堡基金学者。1992至今华西医科大学/四川大学教授。1996至今华西医科大学/四川大学博导。主要承担的课题:国家自然科学基金重大项目及面上项目,博士点基金,CMB基金。
主要学术兼职:国际法医遗传学会(International Society of Forensic Genetics, ISFG)中文专委会(Chinese Speaking Working Group of ISFG, Chinese WG)主席,中国法医学会物证专业委员会主任委员,全国高等医学教育学会法医学教育分会副理事长,《中华医学遗传学杂志》副主编,《中国法医学杂志》编委会副主任委员。
主要著作及获奖情况:主编《法医学》(全国高等学校规划教材,高等教育出版社,2004),主编《法医物证学》(国家十五规划教材,人民卫生出版社,2004)。56篇论文收录于SCI。2006年获四川大学首届教学名师称号。2005年获教育部高等教育国家级教学成果二等奖。2005年获全国高等医药优秀教材二等奖。2004年获卫生部有突出贡献中青年专家荣誉称号。2003年获四川省学术和技术带头人称号。1998年获"四川省有突出贡献专家"荣誉称号。1997年获国务院特殊津贴奖励。
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成果数
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【期刊论文】POPULATION GENETICS OF THEIE SIR POLYGORPHISMS IN A CHINESE POPULATION
侯一平, Hou a+ P Gills M. Staak+ C.Schmitt+ M.Prinz+
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-1年11月30日
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【期刊论文】HOW MANY STR MARKERS ARE ENOUGH FOR PATERNITY IDENTlFICATION
侯一平, Y. Hou a, Z. Song b, Y Li a, J. Wu a, J. Zhang a
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-1年11月30日
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【期刊论文】POLYMORPHISMS OF CHROMOSOME Y SPECIFIC SHORT TANDEM REPEATS IN A CHINESE POPULATION
侯一平, Y.Hou a, J Wu a, Y Li a, J Zhang a, M Prinz b
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-1年11月30日
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侯一平, Hou Yiping, Gou Qing, Wu Meiyun
Hum Genet (l993) 90: 661-662,-0001,():
-1年11月30日
Phenotypes of inter-alpha-trypsin-inhibitor (ITI) have been determined by isoelectric foCUSing on polyacryl-amide gels followed by immunofixation. The phenotype fre-quencies of ITI in the Han population in Chengdu. P. R. China have been investigated using this method. In addition, family studies have been conducted in 21 families. The re-suits show that ITI iS polymorphic in the Han population in Chengdu. China. The allele frequencies are as follows: ITI*1=0.5763. ITl*2=0.4107. ITl*3=0.0130. ITI is thus a new and promising genetic marker that can be used in the field of forensic haematogenetics.
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【期刊论文】Genetic Variation of the Amplified VNTR Polymorphism COL2A1 in Chinese and German Populations
侯一平, Yiping Hou a, b Cornelia Schmitt b Christoph Puers c Mechthild Prinz b
Hum Hered 1994; 44: 114-119,-0001,():
-1年11月30日
The amplifiable VNTR polymorphic system COL2A1 has been investigated in Chinese and German population samples. In order to accurately identify COL2A1 alleles. a number of hu-man allele ladders were prepared. A total of 14 different alleles in 23 genotypes was observed in the Chinese population. while in the German population there were 11 alleles in 24 geno-types. Four new alleles were observed. AIl of them werc found in the Chinese and one was also observed in the German pop-ulation. There was no statisticaI difference in the allele distri-bution between two Gcrman populations from Miinster and Koln, while the allele frequency distribution in the Chinese population differed significantly from the German.
Genetic polymorphism COL2A1 Polymerase chain reaction Chinese German Variable number of tandem repeats
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【期刊论文】COMPARISON OF DIFFERENT TESTS FOR DEVIATION FROM-WEINBERG EQUILIBRIUM
侯一平, Y. Hou a, M. Pflnz and M. Staak
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-1年11月30日
Institute of Forensic Medicine, west China University of MedicaI scIences, 610044 chengdu, PR Institute of Forensic Medicine, University of Cologne, 50823 KOin, FRG Since its introduction in 1985, VNTR polymorphism analysis has rapidly become a routine technique for forensic biology and population genetics But sO far there ore stlll some controversies surrounding VNTR polymorphisms. one of them being whether they violate the assumptions of Hardy-Weinberg equilibrium (HWE). Conceming biostotical tests the only significant dfiference between VNTR loci analysed by AMp-FLP and tradifionaI serological markers is that there are more alleles at a particular VNTR locus. so that not all genotypes can be observed in a relatively sinail sample Therefore. some indireat methods have been suggested to test HWE forthese VNTR Ioci (1-4), but the efficiency ofthem was not evaluated. our Purpose here is to Compare the efficiency of dfiferent statisticaI tests and to suggest a more sensitive new modification
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【期刊论文】POLYMORPHISMS OF 13 STR MARKERS IN CHINESE POPULATION
侯一平, Y. Hou a, Y. Li a, J. Wu a, J. Tang a. M. Prinzb
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-1年11月30日
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【期刊论文】Typing Y Chromosome STR Haplotypes Using Redesigned Primers
侯一平, Yiping Hou, M.D.; Ji Zhang, M.D.; Dahong Sun, Ph.D.; Yinbi Li, M.D.; Jin Wu, M.D.; Sizhong Zhang, M.D.; and Mechthild Prinz, Ph.D.
J Forensic Sci 2002; 47 (1): 215-217,-0001,():
-1年11月30日
A panel of Y-specific STR loci, including DYS19, DYS389, DYS390, DYS391, DYS392, and DYS393 was analyzed using horizontal nondenaturing polyacrylamide gel electrophoresis with a discontinuous buffer system (horizontal disk-PAGE). In order to obtain correct results for the larger DYS389 and DYS392 alleles, it was necessary to design new primers that bind closer to the repeat region and lead to a significant reduction of the amplified fragment size. Using the modified primer sets the horizontal disk-PAGE results were consistent with a nondenaturing approach using fluorescent primers and a 377 automated sequencer. The modified procedure also amplifies the second repeat stretch at the duplicated DYS389 locus as a single fragment, which results in an immediate allele identification. The results indicate that horizontal disk-PAGE with silverstaining is a simple approach to type the recommended Y-specific STR markers.
forensic science,, chromosome Y,, horizontal polyacrylamide gel electrophoresis,, primers,, short tandem repeats,, haplotype
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【期刊论文】D20S161 data for three ethnic populations and forensic validation
侯一平, Y. P. Hou
Int J Legal Med (1999) 112: 400-402,-0001,():
-1年11月30日
In order to evaluate the forensic applicability of the STR locus D20S161 and construct a preliminary database, the genotype distributions and allele frequencies in five populations from three main ethnic groups were investigated, including Germans, Slovakians, African Americans, Japanese and Chinese. A total of 512 samples from unrelated individuals and 85 confirmed father/mother/ child triplets were analyzed by PCR and allele determination was carried out by comparison with a sequenced human allelic ladder. The results showed that D20S161 typing was both precise and reliable. A total of 7 alleles was found in these populations and no evidence of deviation from Hardy-Weinberg equilibrium was observed. Pairwise comparisons between populations showed that there were significant differences in the distributions of the allele frequencies among the three main ethnic groups. No mutation events were observed from the confirmed father/mother/child triplets. With a maximum likelihood method, the mutation rate was indirectly estimated as 2.5 × 10–5. These results suggest that D20S161 is a useful marker for forensic casework and paternity analysis.
Short tandem repeats
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侯一平, Y.P. Hou *, M.S. Shi, L.C. Liao, J. Yan, J. Zhang, J. Wu, Y.B. Li
International Congress Series 1288(2006)16-18,-0001,():
-1年11月30日
The purpose of our work was to establish a method for analysis of Y-SNP based on the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The results of our study implied that the analysis of Y-SNP was proved to be suitable for forensic application and provided new genetic markers for the forensic purpose. D 2005 Published by Elsevier B.V.
Matrix-assisted laser desorption/, ionization time-of-flight mass spectrometry, Single nucleotide polymorphisms, Y chromosome
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