赵冰
个性化签名
- 姓名:赵冰
- 目前身份:
- 担任导师情况:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
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学科领域:
分析化学
- 研究兴趣:
赵冰,1964年生,博士学位、教授、博士生导师,就职于吉林大学超分子结构与材料国家重点实验室。研究方向主要为超分子光谱,发展了一些分子水平超灵敏检测的原理和方法;率先把SERS基底范围扩展到半导体材料领域,不仅大大的拓宽了SERS的基底材料,也是对相关SERS传统理论的一个极大突破;利用组装技术制备图案化的SERS基底,大大提高了SERS检测的灵敏度、稳定性和重复性;把纳米粒子探针标记技术与表面超灵敏检测有机结合,形成一种新型光谱学技术和方法,实现了蛋白质组的原位光谱检测和免疫的超灵敏分析。
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629
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成果数
10
赵冰, Xiaoling Li, Junhu Zhang, Weiqing Xu, Huiying Jia, Xu Wang, Bai Yang, Bing Zhao, Bofu Li, and Yukihiro Ozaki
Langmuir2003, 19, 4285-4290,-0001,():
-1年11月30日
Mercaptoacetic acid-capped spherical silver nanoparticles with a diameter of about 17nmwere prepared by a simple chemical reaction. The formation process of the silver nanoparticles was investigated by UV-visible(UV-vis) spectroscopyandtransmission electron microscopy.Theresultsshowthat the spherical and rodlike particles were formed at the beginning of the reaction, and then the rodlike particles were gradually converted into spherical particles with the reaction continuing. Finally, the content of the rodlike particles was less than 3% in the silver colloid. Thus, the final obtained silver nanoparticles were uniform in their shapes and showed little variation in their sizes. This silver colloid can remain stable for several weeks, which makes it convenient for use in practice. We also investigated the effect of Cl
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赵冰, Lehui Lu, Haishui Wang, Yonghui Zhou, Shiquan Xi, Hongjie Zhang, Jiawen Hu and Bing Zhao
CHEM. COMMUN. , 2002, 144-145,-0001,():
-1年11月30日
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【期刊论文】Self-Assembled Metal Colloid Films: Two Approaches for Preparing New SERS Active Substrates
赵冰, Xiaoling Li, Weiqing Xu, Junhu Zhang, Huiying Jia, Bai Yang, Bing Zhao, Bofu Li, and Yukihiro Ozaki
Langmuir2004, 20, 1298-1304,-0001,():
-1年11月30日
In this paper, we propose two new approaches for preparing active substrates for surface-enhanced Raman scattering (SERS). In the first approach (method 1), one transfers AgI nanoparticles capped by negatively charged mercaptoacetic acid from a AgI colloid solution onto a quartz slide and then deoxidizes AgI to Agnanoparticles on the substrate. The second approach (method 2) deoxidizes AgI to Agnanoparticles in a colloid solution and then transfers the Ag nanoparticles capped by negatively charged mercaptoacetic acid onto a quartz slide. By transfer of the AgI/Ag nanoparticles from the colloid solutions to the solid substrates, the problem of instability of the colloid solutions can largely be overcome. The films thus prepared by both approaches retain the merits of metal colloid solutions while they discharge their shortcomings. Accordingly, the obtained Ag particle films are very suitable as SERS active substrates. SERS active substrates with different coverages can be formed in a layer-by-layer electrostatic assembly by exposing positively charged surfaces to the colloid solutions containing oppositely charged AgI/Ag nanoparticles. The SERS active substrates fabricated by the two novel methods have been characterized by means of atomic force microscopy (AFM) and ultraviolet-visible (UV-vis) spectroscopy. The results of AFM and UV-vis spectroscopy show that the Ag nanoparticles grow with the increase in the number of coverage and that most of them remain isolated even at high coverages. Consequently, the surface optical properties are dominated by the absorption due to the isolated Ag nanoparticles. The relationship between SERS intensity and surface morphology of the new active substrates has been investigated for Rhodamine 6G (R6G) adsorbed on them. It has been found that the SERS enhancement depends on the size and aggregation of the Ag particles on the substrates. Especially, we can obtain a stronger SERS signal from the substrate prepared by method 1, implying that for the metal nanoparticles capped with stabilizer molecules such as mercaptoacetic acid, the in situ deoxidization in the film is of great use in preparing SERS active substrates. Furthermore, we have found that the addition of Cl
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赵冰, Xu Wang, Bing Zhao, Yue Wang, Yuqing Wu, Weiqing Xu, Yuguo Fan
Materials Science anf Engineering C10(1999)3-6,-0001,():
-1年11月30日
Near-infrared surface-enhanced Raman spectroscopy was applied to the investigation of 4, 4′-bipyridine, 4, 4′-azopyridine, bissalicy-laldehydeethylenediimine Co (II). and Ni (II). abbreviated as Salen-Co and Salen-Ni, respectively. as mono- and alternating multi-layer self-assembly films deposited onto the roughened silver foil substrate. 4, 4′-Bipyridine, 4, 4′-azopyridine can be adsorbed onto the silver substrate through the interaction of N-atom of the pyridine ring via metal surface. The orientation of molecular long axis for both molecules are normal to the surface of the substrate. The alternating films can be obtained by the coordinate interaction between the pyridine and the metal chelates of Salen-Co and Salen-Ni. The plane of the metal chelates are parallel to the surface of silver substrate. © 1999 Elsevier Science S.A. All rights reserved.
Self-assemblies film, Coordination bond, NIR–SERS
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赵冰, Jiawen Hu, Bing Zhao, Weiqing Xu, Yuguo Fan, Bofu Li, and Yukihiro Ozaki
Langmuir2002, 18, 6839-6844,-0001,():
-1年11月30日
Silver colloids are one of the extensively employed surface-enhanced Raman scattering (SERS) active substrates. To obtain the SERS effect, their aggregation upon addition of analyte is necessary. However, problems of instability and irreproducibility in the magnitude of the signal are caused by the formation of aggregates. Considering that the aggregation of silver colloids is essential to induce small silver clusters, in the present study, we develop a drying process to prepare silver particle films (silver clusters) that are supported directly on a glass slide. These silver particle films arise through the aggregation of silver colloids occurring in thin water films supported on a solid substrate. With the evaporation of water, silver clusters are left on the solid substrate. Thus, the assembly meets perfectly the requirement of aggregation of silver colloids and, at the same time, possesses the stability of solidlike SERS-active substrates. We can easily obtain excellent SERS spectra from these silver particle films. These substrates show great potential in practical applications such as ultrasensitive microanalysis with micro-Raman spectroscopy and are suitable for studying the optical properties of silver clusters. 4-Mercaptopyridine (4MPY) was used to test the utility of the proposed method and to compare it with the chemically deposited silver film (silver mirror) method. The intensity of SERS signals of 4MPY on the silver particle films is stronger by about 100 times than that of 4MPY on the silver mirror. In addition, the experimental results of SERS reveal that the activation agent, coadsorbed chloride ions, can further enhance the SERS signals from both the silver mirror and the silver colloids.
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赵冰, Jiawen Hu, Bing Zhao, Weiqing Xu, Yuguo Fan, Bofu Li, and Yukihiro Ozaki
J. Phys. Chem. B 2002, 106, 6500-6506,-0001,():
-1年11月30日
In this paper, we propose a novel technique for the fabrication of active substrates of surface-enhanced Raman scattering (SERS). It was found that the silver particles themselves and the analyte-covered silver particles can be trapped at the air-water interface. In the presence of electrolyte, for example, KCl that is generally used to activate silver colloids for additional SERS enhancement, the trapped silver particles and clusters can attract each other spontaneously to form two-dimensional silver particle films. By this technique, the prerequisite aggregation of silver colloids for the SERS process is provided. At the same time, because the aggregation occurs only at the interface, problems of irreversible aggregation and instability of silver colloids can largely be overcome. The SERS enhancement ability of these silver particle films is larger by 1-2 orders than that of usual active substrates such as silver colloids and silver mirror. Their strong enhancement ability may arise from the unique two-dimensional structure itself.
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赵冰, Jiawen Hu, Bing Zhao, Weiqing Xu, Bofu Li, Yuguo Fan
Spectrochimica Acta Part A58(2002)2827-2834,-0001,():
-1年11月30日
Surface-enhanced Raman scattering (SERS) of 4-mercaptopyridine (4-mpy) adsorbed on HNO3 etched silver foil, chemically deposited silver films (silver mirror) and silver colloids were measured. The SERS study has revealed that 4-mpy was adsorbed onto the three kinds of silver surfaces by a sulfur-silver bond with the plane of pyridine ring being normal to the silver substrates. The structure of 4-mpy adsorbed on the silver surfaces depends largely on the pH values of environment. When the pH values of the environment are changed, the structure of 4-mpy adsorbed on silver surfaces can easily be altered through a protonation or deprotonation reaction occurring on the N atom of the pyridine ring, and the modified structure shows unique characters on the SERS spectrum. Owing to the remarkable enhancement ability of SERS technique and characteristic spectrum of different species, a monolayer of 4-mpy assembled on a silver mirror holds potential as a H+ sensor for highly sensitive detection of the proton concentration in an aqueous solution.
Surface-enhanced Raman scattering, 4-Mercaptopyridine, Silver colloids, Raman spectra
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赵冰, Shuping Xu, Xiaohui Ji, Weiqing Xu, Xiaoling Li, Lianying Wang, Yubai Bai, Bing Zhao and Yukihiro Ozaki
Analyst, 2004, 129, 63-68,-0001,():
-1年11月30日
This paper reports a novel immunoassay based on surface-enhanced Raman scattering (SERS) and immunogold labeling with silver staining enhancement. Immunoreactions between immunogold colloids modified by a Raman-active probe molecule (e.g., 4-mercaptobenzoic acid) and antigens, which were captured by antibody-assembled chips such as silicon or quartz, were detected via SERS signals of Raman-active probe molecule. All the self-assembled steps were subjected to the measurements of ultraviolet-visible (UV-vis) spectra to monitor the formation of a sandwich structure onto a substrate. The immunoassay was performed by a sandwich structure consisting of three layers. The first layer was composed of immobilized antibody molecules of mouse polyclonal antibody against Hepatitis B virus surface antigen (PAb) on a silicon or quartz substrate. The second layer was the complementary Hepatitis B virus surface antigen (Antigen) molecules captured by PAb on the substrate. The third layer was composed of the probe-labelling immunogold nanoparticles, which were modified by mouse monoclonal antibody against Hepatitis B virus surface antigen (MAb) and 4-mercaptobenzoic acid (MBA) as the Raman-active probe on the surface of gold colloids. After silver staining enhancement, the antigen is identified by a SERS spectrum of MBA. A working curve of the intensity of a SERS signal at 1585 cm-1 due to the v8a aromatic ring vibration of MBA versus the concentration of analyte (Antigen) was obtained and the non-optimized detection limit for the Hepatitis B virus surface antigen was found to be as low as 0.5
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【期刊论文】Raman scattering study of molecules adsorbed on ZnS nanocrystals
赵冰, Yanfei Wang, Zhihua Sun, Hailong Hu, Shengyu Jing, Bing Zhao, Weiqing Xu, Chun Zhao and John R. Lombardi
JOURNAL OF RAMAN SPECTROSOPY J. Raman Spectrosc. 2007; 38: 34-38,-0001,():
-1年11月30日
The adsorption of 4-mercaptopyridine (4-Mpy) molecules on ZnS nanocrystals was investigated by means of Raman spectroscopy. We compared the Raman signals of 4-Mpymolecules adsorbed on ZnS nanocrystals and Ag substrate. The differences in the adsorption of 4-Mpy molecules on the semiconductor and the metal substrate were noted. The results demonstrated that adsorbed species on the semiconductor ZnS nanocrystals can be detected by Raman spectroscopy. Copyright
ZnS nanocrystals, 4-mercaptopyridine, 4-mercaptobenzoic acid, SERS
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【期刊论文】Optical properties of Ag/CdTe nanocomposite self-organized by electrostatic interaction
赵冰, Yanfei Wang, Minjie Li, Huiying Jia, Wei Song, Xiaoxia Han, Junhu Zhang, Bai Yang, Weiqing Xu, Bing Zhao
Spectrochimica Acta Part A64(2006)101-105,-0001,():
-1年11月30日
Ag/CdTe nanocomposite was prepared via self-organization process by electrostatic interaction between positively charged CdTe quantum dots and negatively charged Ag nanoparticles and examined with respect to their optical properties. The positively charged CdTe quantum dots and negatively charged Ag nanoparticles were synthesized separately by modifying nanoparticles surface with cationic and anionic thiol compounds, respectively. The result showed that the mixing ratio of Ag nanoparticles to CdTe quantum dots is an important parameter for controlling resulting composites. The resulting solution is optically transparent if one component is in excess. Photoluminescence of CdTe quantum dots undergoes considerably quenching if CdTe nanocrystals are in excess and SERS spectra of BVPP absorbed on Ag colloid became stronger if Ag nanoparticles are in excess. Nevertheless, while the ratio is approximately 1, micrometersized solid composite is obtained with the elapse of 1 h after mixing. SERS spectra for solid composite only exhibit the signals of the CdS nanocrystal which reflected that prolonged refluxing during the synthesis leads to a partial hydrolysis of the thiols and to the incorporation of the sulfur from the thiol molecules into the the growing nanoparticles to form mixed CdTe(S) nanocrystal, similar to CdTe/CdS core/shell structure. From the results, we conclude that optical properties of Ag/CdTe are dependent on the mixing ratio of both nanoparticles.
Ag nanoparticle, CdTe(, S), nanocrystal, SERS
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