贺浪冲
中药物质基础分析;天然药物开发研究;体内药物分析;手性药物色谱分析。
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- 姓名:贺浪冲
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学术头衔:
博士生导师
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学科领域:
岩土力学
- 研究兴趣:中药物质基础分析;天然药物开发研究;体内药物分析;手性药物色谱分析。
贺浪冲,男,1957年8月生,分析化学博士,药物分析教授,博士生导师。现任西安交通大学药学院副院长,国家中医药管理局中药分析实验室和陕西省天然药物研究与工程重点实验室主任。中国药学会药物分析专业委员会副主任委员,国家新药评审委员会专家,教育部高等学校制药工程教学指导分委员会委员,陕西省药学会常务理事,陕西省药学会药物分析专业委员会主任委员,陕西省药理学会制药工程专业委员会副主任委员,陕西省化学会理事,《药学学报》、《药物分析杂志》、《中国药学杂志》、《中国新药与临床杂志》、《世界科学技术—中药现代化》、《西安交通大学学报(医学版)》等杂志编委。
研究领域:中药物质基础分析;天然药物开发研究;体内药物分析;手性药物色谱分析。
自1986年以来,一直从事药物分析和新药开发方面的教学与研究工作,先后主持国家发改委高技术平台研究计划、国家科技部“十一五”科技支撑计划、国家自然科学基金重点项目等20余项;获陕西省政府科技进步一等奖和二等奖各1项,主持研究国家中药新药2项,主持申报国家发明专利17项,已授权9项;主编全国高等学校“十一五”规划教材《法医毒物分析》和《工业药物分析》;培养药物分析专业博士和硕士研究生85名,在国内外学术刊物发表研究论文200余篇。1992年获中国化学会颁发的“优秀青年化学奖”,1996年获卫生部“吴阶平-保罗?杨森医药学奖”药物分析二等奖,1998年获国务院政府特殊津贴,1999年获中国药学发展奖。
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贺浪冲, Langchong He and Sicen Wang
Arch Pharm Res Vol 26, No.9, 763-767, 2003,-0001,():
-1年11月30日
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贺浪冲, Sicen Wang, Langchong He, and Bofeng Yun
Arch Pharm Res Vol 28, No.3, 319-324, 2005,-0001,():
-1年11月30日
The present study was designed to study the difference effects between nicardipine and its twoenantiomers on thoracic artery of rabbit. A high-performance liquid chromatographic methodwas used to prepare the two enantiomers of nicardipine. The thoracic artery of rabbit wasremoved. The vessels were cut into 3 mm in width and 15 mm in length spiral strips andimmersed into tissue baths. The concentration-response curves of nicardipine and its enantiomerswere obtained by cumulative administration of the vasoconstrictors. Nicardipine and theenantiomers could shift the dose-response curves of NE, KCl or CaCl2 to right in a nonparallelmanner and decrease the maximum effective in a concentration-depended manner, respectively.The pD2' value of R-(-)-nicardipine showed significantly effective than that of nicardipineand S-(+)-nicardipine (P<0.01). There was not obviouse difference between the pD2' value ofnicardipine and S-(+)-nicardipine (P>0.05). The results demonstrate that the stereoselectiveinteraction between R-(-)-nicardipine and L-calcium channel receptor is more stronger thanthat of S-(+)-nicardipine.
Nicardipine,, Enantiomers,, Vasoconstriction,, Stereoselectivity
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贺浪冲, Ming-Jin Liang, Lang-Chong He *, Guang-De Yang
Life Sciences 78(2005)128-133,-0001,():
-1年11月30日
Effective components, ligustilide and butylidenephthalide, from Ligusticum Chuanxiong (Ligusticum wallichii Franchat, Umbelliferae) werescreened and identified by using a cell membrane chromatography (CMC) and a gas chromatography/mass spectrometry (GC/MS). Thecomponents showed the effects of inhibiting vasoconstriction in vitro on rat abdominal aorta segments. The screening procedure was performed ina rat artery CMC column (50mm×2.0mm I.D.) with a sodium phosphate buffer (pH 7.4) as mobile phase at 37℃. The identification wasaccomplished by a DB-5MS 30m capillary column (0.25 mm I.D., 0.25 Am film thickness) with helium as carrier gas operating under programcontrol temperature and electron impact ionization mass spectrometer in a scan mode. Results demonstrated that ligustilide andbutylidenephthalide can act on rat artery cell membrane similar to verapamil in CMC system. They significantly inhibited the vasoconstrictionsinduced by norepinephrine bitartrate (NE) and calcium chloride (CaCl2). The relaxing effect of ligustilide on the NE-and CaCl2-inducedconstrictions is more potent than that of butylidenephthalide. Ligustilide and butylidenephthalide seem to be the two main effective components ofLigusticum Chuanxiong as a traditional Chinese medicine for treating blood vessel diseases.
Ligustilide, Butylidenephthalide, Vasodilatation, Ligusticum Chuanxiong, GC/, MS, CMC
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贺浪冲, Jing Zhang, Langchong He, Qiang Fu
,-0001,():
-1年11月30日
A monolithic molecularly imprinted polymer (mMIP) with specific recognition ability forstrychnine was prepared by in-situ polymerization, using methacrylic acid (MAA) as a functionalmonomer, ethylene glycol dimethacrylate (EDMA) as a cross-linking agent, toluene anddodecanol as porogenic solvents and 2, 2¢-azobisisobutyronitrile (AIBN) as a initiator. Scanningelectron microscopy and mercury intrusion porosimetry were used to identify the structuralfeatures of the mMIP. The results show that there were three kinds of pore structures. The largethrough-pore structure allows mobile phase to flow through a column of mMIP with a low backpressure and the other pores lead to the molecular recognition. Some chromatographic conditionssuch as the pH and the composition of the mobile phase were characterized. Strychninewas separated from compounds such as indole, quinine and brucine. The possible recognitionmechanisms were ionic and hydrogen bonding interactions between the strychnine moleculeand the mMIP.
Column liquid chromatography Molecularly imprinted polymer Strychnine Monolithic column In-situ polymerization
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