鄢明
长期从事手性催化剂的设计、合成及在手性药物合成中的应用。
个性化签名
- 姓名:鄢明
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学术头衔:
博士生导师
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学科领域:
药物化学
- 研究兴趣:长期从事手性催化剂的设计、合成及在手性药物合成中的应用。
鄢明,男,1987年毕业于四川大学化学系,1992年于华西医科大学药学院获硕士学位,1997年于中国科学院化学研究所获博士学位。1997-2000年在香港理工大学应用化学和生物系进行博士后研究,2001-2003年任美国亚利桑纳大学化学系访问学者,2003年回国工作。长期从事手性催化剂的设计、合成及在手性药物合成中的应用。发展了手性螺环氧膦配体Spir-OP,并成功应用于金属铑催化的多种烯烃的不对称氢化反应。首次发现手性双齿亚磷酸酯配体,对于铜催化的有机锌试剂与烯酮的共轭加成反应具有很高的对映控制能力,也研究了手性亚磷酸酯-金属铑催化剂在烯烃的不对称氢甲酰化反应中的性能。此外也发现了过渡金属催化下重氮化合物有关的多种高选择性新反应,并应用于含氮杂环体系的合成中。近年来从事手性噁唑烷酮类抗菌药物的合成新方法以及结构修饰研究,也开展3-酰胺基-2,6-哌啶二酮类抗肿瘤药物的合成和抗肿瘤活性研究。至今已在J. Am. Chem. Soc.; Angew. Chem. Int. Ed.; Organic Letters; J. Org. Chem; Chemical Communications; Adv. Synth. Catal.; Tetrahedron Letters; Tetrahdron:Asymmetry.等国内外核心专业期刊上发表研究论文30余篇,SCI检索到的引用次数为243次,获得美国专利1项,中国专利2项。现承担国家自然科学基金、教育部回国留学人员基金和中山大学科研启动基金项目。
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主页访问
1225
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0
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成果阅读
275
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成果数
8
鄢明, Ming Yan, * Wei-Jie Zhao, Dan Huang and Shun-Jun Ji
Tetrahedron Letters 45(2004)6365-6367,-0001,():
-1年11月30日
The reaction of aryldiazoacetates with enamines catalyzed by copper and rhodium complexes provided c-ketoesters in good yields. Careful analysis of the crude reaction mixture revealed a substituted enamine as the primary product, which was hydrolyzed over silica gel to give a c-ketoester as the final product. A reaction mechanism involving nucleophilic addition of an enamine to a metal carbene and subsequent hydrogen transfer was proposed.
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鄢明, Michael P. Doyle, * Ming Yan, Wenhao Hu, and Luisa S. Gronenberg
J. AM. CHEM. SOC. 2003, 125, 4692-4693,-0001,():
-1年11月30日
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【期刊论文】Catalysts with Mixed Ligands on Immobilized Supports. Electronic and Steric Advantages
鄢明, Michael P. Doyle* and Ming Yan, Han-Mou Gau, Erich C. Blossey
Org. Lett., Vol. 5, No.4, 2003,-0001,():
-1年11月30日
Immobilized dirhodium (Ⅱ) catalysts having mixed chiral ligands enhance reactivity (AH) azetidinone) and influence stereoselectivity in cyclopropanation and carbon-hydrogen insertion reactions.
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鄢明, Michael P. Doyle* and Ming Yan
J. Org. Chem. 2002, 67, 602-604,-0001,():
-1年11月30日
Diazo coupling reactions are capable of forming E,E,E-trienes from cinnamaldehydes in good yield. An efficient methodology is reported for the production of styryldiazomethanes that are subsequently used with catalysis for coupling and for cyclopropanation. A vast difference in product selectivity is seen with styryldiazomethane generated from the corresponding hydrazone via manganese dioxide oxidation and that formed in situ by treatment of the tosylhydrazone sodium salt of cinnamaldehyde with transition metal catalysts. This observation impacts understanding of the reaction mechanism for diazo decomposition.
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鄢明, Michael P. Doyle* and Ming Yan
Tetrahedron Letters 43(2002)5929-5931,-0001,():
-1年11月30日
The chiral dirhodium(Ⅱ) catalyst Rh2(MEAZ)4 increases diastereocontrol for intermolecular O-H insertion reactions of diazo esters having a chiral auxiliary over that achieved with Rh2(OAc)4.
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鄢明, Ming Yan, Zhong-Yuan Zhou and Albert S. C. Chan*
Chem. Commun., 2000, 115-116,-0001,():
-1年11月30日
Highly enantioselective conjugate addition of diethylzinc to a, β-unsaturated lactones was achieved by using chiral diphosphite-copper catalysts; the structure of a chiral diphosphite-copper (I) catalyst was determined by single crystal X-ray diffraction.
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【期刊论文】Asymmetric hydrocyanation of olefins catalyzed by chiral diphosphite-nickel complexes
鄢明, Ming Yan, Qian-Yong Xu and Albert S. C. Chan*
Tetrahedron: Asymmetry 11(2000)845-849,-0001,():
-1年11月30日
Chiral aryl diphosphite ligands derived from binaphthol were found to be effective in the nickel-catalyzed hydrocyanation of a variety of olefins. Enantioselective hydrocyanations of styrene, 4-substituted styrenes and norbornene were achieved with excellent regioselectivity and moderate enantioselectivity. The hydrocyanation of vinyl acetate gave 72.9% ee. The catalytic activity and the enantioselectivity of the Ni(0)-diphosphite complexes were found to be highly dependent on the structures of the ligands.
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鄢明, Ming Yan and Albert S. C. Chan *
Tetrahedron Letters 40(1999)6645-6648,-0001,():
-1年11月30日
A series of C2-symmetric aryl diphosphites based on chiral binaphthol were prepared and their copper complexes were found to be efficient catalysts for the conjugate addition of diethylzinc to cyclic enones. Good enantioselectivities (up to 89.8 and 88.7% ee, respectively) were obtained in the conjugate addition of diethylzinc to 2-cyclohexenonc and 2-cyclopcntenone.
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