顾忠伟
1. 生物医用高分子;2. 纳米生物材料;3. 药物及生物活性物质控释系统;4. 自组装与有序结构调控。
个性化签名
- 姓名:顾忠伟
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
材料科学
- 研究兴趣:1. 生物医用高分子;2. 纳米生物材料;3. 药物及生物活性物质控释系统;4. 自组装与有序结构调控。
顾忠伟,四川大学教授、博士生导师,享受国家政府特殊津贴(1995年)。连续两次担任国家973计划生物医用材料项目首席科学家(1999-2004,2005-2010),获生物材料科学与工程Fellow(国际生物材料科学与工程学会联合会授予世界杰出生物材料专家终身荣誉称号)。
现任教育部985工程“四川大学生物医学工程与技术科技创新平台”首席科学家、四川大学第二届学术委员会委员、四川大学交叉学科学位评定委员会副主任委员;中国协和医科大学中国医学科学院博士生导师,浙江大学、南开大学、沈阳药科大学、苏州大学等兼职教授;世界生物材料科学与工程学会联合会国际委员会委员、中国生物材料委员会副主席兼秘书长、中国材料研究学会常务理事、中国材料研究学会生物医学材料分会副理事长兼秘书长、中国医药生物技术协会纳米生物技术分会常务委员、四川省生物技术协会生物医学工程分会会长、美国药物控制释放学会会员;国家863计划生物与医药领域总体专家组成员、国家食品药品监督管理局全国药品审评专家、全国材料科学技术名词审定委员会委员;南开大学生物活性材料教育部重点实验室学术委员会副主任、武汉大学生物医用高分子材料教育部重点实验室学术委员会委员;国际学术期刊Biomed. Mater.,Int. J Med. Eng. & Inf.等杂志编委,J Biomed. Mater. Res.-A,Biomacromolecules,Int. J. Pharm,J. Mater. Sci: Mater. in Med.等杂志评委。曾任国家中长期科学技术发展规划人口与健康战略研究专题组副组长、国家自然科学基金委员会工程与材料科学部专家评审组成员。
自七十年代中期以来,致力于生物医用高分子材料、药物/生物活性物质控释系统、纳米生物材料等领域的基础和应用基础研究,先后主持国家973、“七.五”、“八.五”、“九.五”科技攻关、国家自然科学基金重点和面上、国家新药研究基金及国际合作项目等20余项国家级科研项目,以及10余项部省级科研项目。曾获得两项部委科技奖励;在国内外重要学术刊物上发表学术论文100余篇(其中SCI源刊论文80余篇),以及60余篇国际及全国学术会议报告摘要,并在世界生物材料大会、亚洲生物材料大会、中国材料学会年会、全国高分子年会等作邀请报告;译著作7部(含章节);申请/授权专利8项(含合作)。
主要研究方向:1. 生物医用高分子;2. 纳米生物材料;3. 药物及生物活性物质控释系统;4. 自组装与有序结构调控。
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顾忠伟, Zhong-wei Gu, Vladimir Omelyanenko, Pavia Kopeckova, and Jindrich Kopecek* Cestmir Konak*
Macromolecules 1995, 28, 8375-8380,-0001,():
-1年11月30日
The solution properties of a N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer containing Zn(Ⅱ) 4,9,16,23-tetraaminophthalocyanine (HPMA-TAPC-Zn copolymer) attached to the copolymer via oligopeptide side chains (GFLGG) were studied using light scattering and spectroscopic methods. The light scattering data indicated that the copolymer formed aggregates in aqueous solutions stable down to c=2x10-5g/mL. The extent of aggregation decreased with increasing concentration of detergents in buffer solutions or organic solvents in mixed solvents as Tris buffer/DMSO. Dramatic changes in the aggregate formation were observed in the vicinity of a mixture composition of 60 vol% of DMSO. The local interactions of hydrophobic TAPC-Zn species were studied by absorption and fluorescence spectrometry. The majority of all TAPC-Zn species are dimerized in aqueous solutions by hydrophobic interactions and hydrogen bonds. The proportion of TAPC-Zn monomers and dimmers estimated for Tris buffer/DMSO mixtures from both the absorption and fluorescence spectra was correlated to the aggregation behavior of the copolymer. The copolymer aggregation was explained by the random association model. Mostly point-like contacts formed by TAPC-Zn dimers are supposed for aqueous solutions of HPMA-TAPC-Zn copolymer.
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顾忠伟, Chang-Ming Donga, Kun-Yuan Qiua, *, Zhong-Wei Gub, Xin-De Fenga
Polymer 42(2001)6891-6896,-0001,():
-1年11月30日
D, L-3-metbylglycolide (MG) was successfully polymerized with multifunctional initiator (trimethylolpropane (TMP) or pentaerythritol (PTOL)) and stannous octoate (SnOct2) catalyst in bulk at 110℃. The effects of molto ratios of monomer to initiator, monomer to catalyst and monomer conversion on the molecular weight of polymer were studiedi For the homopolymerization of MG with TMP initiator and SnOct2 catalyst, the molecular weight of polymer increases from 6840 to 35 010 with the molto ratio of monomer to initiator (45-450), and the molecular weight distribution is from 1.15 to 1.35. The results indicate that in the homopolymerization of MG, the molecular weight of polymer is proportional to the molar ratio of monomer to initiator and the monomer conversion. The molar ratio of monomer to catalyst has no influence on the molecular weight of polymer at least within the range of 500-4000. 1 H NMR spectra of the resulting polymers obtained from the homopolymerization of MG show that the homopolymerization of MG with TMP or PTOL initiator and SnOct2 catalyst produced two types of three arm or fore-arm star-sbaped polymers. The bulk ring-opening homopolymerization of MG proceeds through a "coordina tion-insertion" mechanism and follows the selective acyl-oxygen bond cleavage reaction, 13C NMR spectroscopy indicates that the obtained poly (D,L-lactic acid-co-glycolic acid) (50: 50, in molto-ratio; D,L-PLGA50) has an alternating structures of lactyl and glycolyl units.
Multifunctional initiator, Ring-opening polymerization, Star-shaped poly (, D,, L-lactic acid-alt-glycohc acid),
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顾忠伟, Chang-Ming Dong, † Kun-Yuan Qiu, *, † Zhong-Wei Gu, ‡ and Xin-De Feng†
Macromolecules 2001, 34, 4691-4696,-0001,():
-1年11月30日
Two types of three-arm or four-arm star-shaped hydroxy-terminated poly(ε-caprolactone) (PCL) were successfully synthesized via the ring-opening polymerization of ε-caprolactone (CL) with multifunctional initiator, such as trimethylolpropane (TMP) or pentaerythritol (PTOL), and stannous octoate (SnOct2) catalyst in bulk at 110℃. The number-average molecular weight of PCL is proportional to the molar ratio of monomer to initiator. 1H NMR spectroscopy of the resulting PCL indicates that it contains a primary hydroxy end group in each arm. The star-shaped PCL with hydroxy end groups can be used as a macroinitiator for block copolymerization with DL-3-methylglycolide (MG) using SnOct2 catalyst in bulk at 115℃. 1H NMR spectra of the resulting block copolymers show that the molecular weights and the unit compositions of the block copolymers were controlled by the molar ratios of MG monomer to hydroxy groups of PCL and MG to CL in feed, respectively. Moreover, the molecular weights of the resulting block copolymers linearly increased with the increase of the molar ratios of MG to CL in feed. The molecular weight distributions of the block copolymers were rather narrow (Mw/Mn) 1.09-1.26). 13C NMR spectra of the resulting block copolymers clearly show their diblock structures, that is, PCL as the first block and poly (DL-lactic acid-alt-glycolic acid) (DL-PLGA50) with alternating structures of lactyl and glycolyl units as the second block. Therefore, two types of three-arm or four-arm star-shaped diblock copolyesters comprising the first block PCL and the second block DL-PLGA50 were successfully synthesized via the sequential ring-opening polymerization of CL with multifunctional initiator and SnOct2 catalyst and then followed by copolymerization with MG.
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【期刊论文】Preparation and Evaluation of Proliposomes Containing Clotrimazole
顾忠伟, Mei-Ying NING, *, a, b Ying-Zhi GUO, b Huai-Zhong PAN, b He-Ming YU, b and Zhong-Wei GU b
Chem. Pharm. Bull. 53(6)620-624 (2005),-0001,():
-1年11月30日
Clotrimazole (CT)-containing proliposomes were prepared by penetrating an ethanol solution of CT and Egg phosphatidylcholine (PC) into microporous sorbitol particles, followed by vacuum evaporation of the solvent. As a result, CT proliposomes with free-flowing flowability were obtained. On contact with water, the proliposomes were rapidly converted into a liposomal dispersion, in which a certain amount of CT was entrapped by the liposomes. The result in scanning electronic micrograph confirmed the formation of liposomes structures from proliposomes, and the particles revealed round or ellipse. The ratio of drug to total lipid, ratio of PC to cholesterol and ratio of lipid to sorbitol affected the entrapment efficiency (EE%). The EE% of optimized formulation (CT 10mg, 0.1g total lipid, PC/CH ratio is 60∶40 and 1g sorbitol) in this investigation was 96.2±1.5%. The proliposomes system can provide sustaining release in simulated vaginal fluid at 37±1℃ for 24 h. In-vivo performance of blank proliposomes, a physical mixture of sorbitol and drug, clotrimazole proliposomes and commercial ointment formulation were evaluated using antifungal activity test. At 7 d post-dose, the c.f.u. of C. albicans decreased in proliposomes-treated groups than ointment and the physical mixture (t-Student, p<0.05). The results indicated that CT-containing vaginal proliposomes prolonged drug release and may increase amount of drug retention into the mucosa to result in more antifungal efficacy. In addition, CT-proliposomes did not affect the morphology of vaginal tissues. Therefore, the dosage form might be further developed for safe, convenient, and effective treatment of vaginal candidasis with reduced dosing interval.
proliposome, clotrimazole, vaginal drug delivery
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