余孝其
开展了酶的化学模拟、主体分子的合成及对有机小分子的超分子识别、有机小分子与生物大分子的相互作用和不对称催化、不对称合成方法学等的基础性研究。
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- 姓名:余孝其
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学术头衔:
博士生导师
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学科领域:
有机化学
- 研究兴趣:开展了酶的化学模拟、主体分子的合成及对有机小分子的超分子识别、有机小分子与生物大分子的相互作用和不对称催化、不对称合成方法学等的基础性研究。
余孝其,1983年考入四川大学化学系,1993 年3月获博士学位,1999年7月晋升教授,2001年被评聘为四川大学化学学院有机化学专业博士生导师。现为中国化学会化学生物学专业委员会委员、四川省绿色化学与技术重点实验室副主任、中国博士后科学基金评审专家,中国监控化学品协会技术专家库成员,教育部留学回国人员科研启动基金评审专家,四川省禁化武技术专家,成都市反恐怖工作顾问;教育部高等学校优秀青年教师教学科研奖励计划人选、四川省杰出青年学科带头人培养计划培养人选。国际杂志《The Journal of Organic Chemistry》、《Organic Letters》、《Polymers for Advanced Technologies》、《International Journal of Chemical Kinetics》等的论文评阅人。
已主持过18项国家、省部级及其它类型科研课题,其中包括国家杰出青年基金B、国家自然科学基金重点项目、教育部新世纪优秀人才基金等。获得多项奖励。开展了酶的化学模拟、主体分子的合成及对有机小分子的超分子识别、有机小分子与生物大分子的相互作用和不对称催化、不对称合成方法学等的基础性研究。
共发表研究论文110多篇,其中SCI收录论文近60篇,EI收录论文15篇。在国际重要刊物如 J. Am. Chem. Soc. ;Chem.-Eur. J. ;Org. Lett. ;Chem. Commun. ;Langmuir 等发表的论文被国际国内同行在他们发表的论文中引用近250次。曾获得四川省科技进步奖和校级优秀教学成果奖。
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余孝其, Li Lin, † Xianxing Jiang, † Weixia Liu, † Li Qiu, † Zhaoqing Xu, † Jiangke Xu, † Albert S. C. Chan, ‡ and Rui Wang*, †, ‡
ORGANIC LETTERS 2007 Vol. 9, No. 12 2329-2332,-0001,():
-1年11月30日
This work concerns the asymmetric addition of methyl propiolate to aldehydes with 1,2-dimethoxyethane (DME) as additive and
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余孝其, Qing-Xiang Xiang a, Ji Zhang a, Pei-Yan Liu a, Chuan-Qin Xia a, Zhong-Yuan Zhou b, Ru-Gang Xie a, Xiao-Qi Yu a, *
Journal of Inorganic Biochemistry 99(2005)1661-1669,-0001,():
-1年11月30日
The syntheses, characteristics of dinuclear macrocyclic polyamine zinc complexes and their interaction with plasmid DNA are reported. The two cyclen (1,4,7,10-tetraazacyclododecane) moieties are bridged by rigid and flexible linkages. The crystal structures of Zn2C27H43N8O15Cl4 [5c•(ClO4)3•2H2O] and Zn2C30H43N10O13Cl3 [5e•(ClO4)3•H2O] have been determined. The complexes crystallize in the monoclinic space group C2/c and P2(1)/c with the following unit cell parameters: 5c• (ClO4)3 •2H2O: a=32.568(4) Å, b=14.8593(17) Å, c=19.443(2) Å, a=90.00º, b=119.435(4)º, c=90.00º, Dc=1.551 mg/m3, FW=956.71, F(000)=3932; 5e•(ClO4)3 Æ H2O: a=15.807(2) Å, b=16.756(2)Å, c=16.161(2) Å, a=90.00º, b=97.062(4)º, c=90.00º, Dc=1.546 mg/m3, FW=988.83, F(000)=2032. The distance between the two Zn(II) ions is about 4.0 Å. The structures show that two zinc ions can synergistically interact with the substrate DNA. With this novel structural characteristics, the dinuclear macrocyclic polyamine Zn(II) complexes via the synergetic effect between the two zinc ions can catalyze the cleavage of plasmid DNA (pUC18) with unprecedented speed at physiological conditions.
1,, 4,, 7,, 10-Tetraazacyclododecane (, cyclen), , Macrocyclic polyamine, Dinuclear complexes, Synthesis, DNA cleavage
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余孝其, Can-Ping Du, Zheng-Kai Li, Xiang-Min Wen, Jiang Wu, Xiao-Qi Yu∗, Meng Yang, Ru-Gang Xie
Journal of Molecular Catalysis A: Chemical 216(2004)7-12,-0001,():
-1年11月30日
Manganese(III) 5,10,15-tris(tolyl)-20-(4-hydroxyphenyl) porphyrin covalently attached to Merrifield's peptide resin (MPR) was prepared. The catalysts exhibit high reactivity and β-selectivity toward the epoxidation of cholest-5-ene derivatives with PhIO. Under mild reaction conditions, the catalyst was consecutively reused four times without detectable catalyst leaching and gave over 90% epoxide yield and over 99% β-selectivity.
Diastereoselective epoxidation, Cholest-5-ene derivatives, Supported metalloporphyrins
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余孝其, Jing-Bo Lan, Li Chen, Xiao-Qi Yu, * Jing-Song You and Ru-Gang Xie*
Chem. Commun., 2004, 188-189,-0001,():
-1年11月30日
In the presence of a catalytic amount of a simple copper salt, the coupling of imidazole with arylboronic acids was performed in methanol to give corresponding N-arylimidazoles in almost quantitative yields; this coupling reaction could also be performed in aqueous solutions to give N-arylimidazoles in excellent yields.
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余孝其, Can-Ping Du, a, b Jing-Song You, b Xiao-Qi Yu, b, * Chang-Lu Liu, b Jing-Bo Lana, b and Ru-Gang Xiea, *
Tetrahedron: Asymmetry 14(2003)3651-3656,-0001,():
-1年11月30日
Novel homochiral molecular tweezers comprised of two chiral macrocyclic polyamine skeletons have been developed. These homochiral artificial receptors exhibit excellent chiral recognition ability toward the enantiomers of L-and D-amino acid derivatives (up to KL/KD=7.9, ΔΔG0=−5.12 kJ mol−1) in CHCl3 at 25.0℃.
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余孝其, Jing-Song You, Xiao-Qi Yu∗, Xiao-Yu Su, Tao Wang, Qing-Xiang Xiang, Meng Yang, Ru-Gang Xie
Journal of Molecular Catalysis A: Chemical 202(2003)17-22,-0001,():
-1年11月30日
Chiral metallomicellar supramolecular systems composed of lipophilic l-histidinol have been investigated for their catalytic activities and enantioselectivities in the hydrolysis of N-protected-amino acid esters. Kinetic evidence suggests that the mechanism of the deacylation promoted by ligand 4a with a hydroxyl group and 2a lacking a hydroxyl group is different. The apparent pKa of Zn2+-4a is 6.8 in the micelllar aggregate. The highest enantioselectivity in hydrolysis of R(S)-C12-Leu-PNP (kS/kR=3.01) was obtained with 4a-Zn2+ as catalyst.
Enantioselective hydrolysis, -Amino acid esters, Chiral metallomicelles, l-Histidinol, Synthesis
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余孝其, Qing-Xiang Xiang a, b, Xiao-Qi Yu a, ∗, Xiao-Yu Sua, Qian-Shun Yan a, Tao Wang a, Jing-Song You a, Ru-Gang Xie a
Journal of Molecular Catalysis A: Chemical 187(2002)195-200,-0001,():
-1年11月30日
Four new long chain alkyl substituted 2,6-dioxo-1,4,7,10-tetraazacyclododecanes bearing an alcohol pendant has been synthesized. They coordinate with metal ion (Zn2+, Cu2+, Ni2+, Co2+) to yield 1:1 five-coordinate complexes. The catalytic properties of these complexes have been investigated for the hydrolysis of bis(p-nitrophenyl) phosphate (BNPP) in comicellar solution. The alcohol pendant has a profound effect on the catalytic properties of macrocyclic complexes, and the nature of transition metal ion, micellar microenvironment, hydrolysis temperature, hydrophobic interactions between the metallocatalyst and substrate are also important factors in the hydrolysis ofBNPP. Under the physiological conditions (pH=7.41, 35±0.1◦C), the complexes exhibit higher catalytic activity (up to over 2-3 orders of magnitude) than metal ion or ligand alone in the hydrolysis of BNPP in comicellar solution with 2mM Brij 35.
Synthesis, Macrocyclic polyamine, Hydrolysis, Phosphodiester, Comicelle
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余孝其, Jing-Song You, a Xiao-Qi Yu, a Guo-Lin Zhang, b Qing-Xiang Xiang, a Jing-Bo Lana and Ru-Gang Xie*a
Chem. Commun., 2001, 1816-1817,-0001,():
-1年11月30日
Novel chiral imidazole cyclophane receptors were synthesized by highly selective N-alkylation of the imidazolyl 1Nposition of the bridged histidine diester 2 with the dibromide in the presence of NaH; these receptors exhibit good chiral recognition toward the enantiomers of L-and D-amino acid derivatives (up to KD/KL=3.52, DDG0=23.11 kJmol21) in CHCl3 at 25.0℃.
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余孝其, Xiao-Qi Yu, Jie-Sheng Huang, Wing-Yiu Yu, and Chi-Ming Che*
J. Am. Chem. Soc. 2000, 122, 5337-5342,-0001,():
-1年11月30日
Carbonyl ruthenium(Ⅱ) 5,10,15-tris(4-R-phenyl)-20-(4-hydroxyphenyl)porphyrins (R) Cl, Me) covalently attached to Merrifield's peptide resin were prepared. The catalyst with R) Cl was found to efficiently catalyze Cl2pyNO epoxidation of a wide variety of alkenes, including aromatic and aliphatic terminal alkenes, cis-and trans-stilbene, cyclohexene and cyclooctene, R,â-unsaturated ketones, conjugated enyne, glycal, and protected R-amino alkene. Unusual selectivities were observed for the epoxidations of 1,5-cyclooctadiene, cis-1-phenyl-3-penten-1-yne (9), 3,4,6-tri-O-acetyl-D-glucal (11), and 2-(Boc-amino)-1-phenylbut-3-ene (13), which feature a complete bisepoxide selectivity (1,5-cyclooctadiene), unprecedentedly high cis:trans ratio (9), and complete diastereoselectivity (11 and 13). The new heterogenized metalloporphyrin epoxidation catalysts are of high stability and reusability.
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余孝其, Xiao-Qi Yu, Jie-Sheng Huang, Xiang-Ge Zhou, and Chi-Ming Che*
ORGANIC LETTERS 2000 Vol. 2, No. 15 2233-2236,-0001,():
-1年11月30日
Amidation of a variety of hydrocarbons with PhIdNTs catalyzed by ruthenium and manganese meso-tetrakis(pentafluorophenyl)porphyrins 1 and 2 afforded N-substituted amides in up to 92% yields with good to excellent substrate conversions. By employing catalyst 2, exceptionally high turnovers (up to 2600) were achieved, and the amidations can be effected by directly using PhI(OAc)2/NH2R as amidating reagents; in the case of R) COCF3 a direct amination was realized in up to 90% yield.
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