车向明
消化道肿瘤及普通外科疾病
个性化签名
- 姓名:车向明
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学术头衔:
博士生导师
- 职称:-
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学科领域:
外科学
- 研究兴趣:消化道肿瘤及普通外科疾病
车向明,外科学博士,教授,博士生指导教师。现任普通外科副主任,主持胃肠腺体外科病区工作。现为日本消化外科学会会员,日本胃癌协会会员,中华医学会陕西省外科学会委员,普通外科学会委员,普通外科学会疝及腹壁外科学组副主任委员,西安市外科学会常委,西安交通大学肝胆胰疾病研究会常务理事,《中华腹部疾病杂志》,《中华现代外科学杂志》等杂志编委及特邀审稿专家。
1986年毕业于华西医科大学,1991年获得外科学硕士学位。1996年受卫生部公派(笹川医学奖学金)前往日本研修,后攻读博士学位,2000年在日本获得外科学博士学位。2005年再次赴日进修。
多年来从事消化道肿瘤及普通外科疾病的诊断及治疗,主持卫生部、教育部及日中医学会等基金项目,参与国家及地方科研基金项目多项。研究肿瘤细胞浸润能力、增殖周期及信号传导通路与肿瘤发生发展及预后的关系,肿瘤的基因治疗。致力于胃癌的诊断及外科治疗、综合因素干预对患者预后的改善等方面的研究,观察不同术式对胃癌患者术后生存质量的影响。提出术前放疗对直肠癌患者局部症状改善的细胞学基础。发表论文50余篇,其中SCI收录第一作者6篇。主持完成我校首例小肠移植。
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车向明, Che Xiangming, Shoji Natsugoe, Sonshin Takao, Shuichi Hokita, Sumiya Ishigami, Gen Tanabe, Masamichi Baba, Kazunao Kuroshima, and Takashi Aikou
Vol. 7, 277-282, February 2001,-0001,():
-1年11月30日
The signals of the transforming growth factor b (TGF-b) superfamily are conveyed through cell surface serine/threonine kinase receptors to the intracellular mediatorsknown as Smads. Activation of Smads causes their translocationfrom the cytoplasm to the nucleus, where they functionto control gene expression. The present study analyzedthe expression of Smad4 and TGF-b1 to determine theirprognostic significance in advanced gastric cancer. Of 249cases of advanced gastric cancer, 41 had invaded the muscularlayer, 114 had invaded the subserosal layer, and 94had invaded the serosa. Anti-Smad4 and TGF-b1 antibodieswere used for immunohistochemical staining. Reduced expressionof Smad4 was 75.1%, whereas positive expressionof TGF-b1 was 39.6% in gastric cancer. Smad4 expressionwas related to the depth of tumor invasion (P<0.05), andTGF-b1 expression correlated with tumor gross type (P<0.05). Postoperative survival analysis indicated that patientswho had a tumor with reduced Smad4 expression had apoorer clinical outcome than those with preserved expression (P<0.05). Furthermore, in patients with TGF-b1-positive tumors, survival rate was significantly better inpatients with preserved Smad4 expression than in those withreduced Smad4 expression (P<0.05). According to multivariateanalysis, Smad4 expression acted as an independentprognostic factor. Smad4 expression, particularly in theTGF-b pathway, is an effective predictor of outcome forpatients with advanced gastric cancer.
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