Objective. To investigate the effects of combined administration of octreotide and methylglucamine diatrizoate in the older persons with adhesive small bowel obstruction. Patients and methods. One hundred and sixty-two consecutive patients who had suffered from adhesive intestinal obstruction without clinical evidence of strangulation or gangrene were randomised into two groups, a control group (treated conservatively, n=82) and a contrast group (treated with combined administration of octreotide and methylglucamine diatrizoate, n=80). A laparotomy was performed in both the two groups if symptoms of strangulation developed or the obstruction did not resolve spontaneously after 72 h. Results. Statistically significant rapid reduction in pain score, lower amount of nasogastric drainage, shorter hospital stay, lower operative rate and lower postoperative morbidity were observed in the contrast group. Among the non-operative patients, earlier passage of stool and gas, earlier first oral intake and shorter duration of nasogastric tube placement were significantly more frequently observed in the contrast group. No difference in the rate of readmission was found between the two groups. Conclusions. Combined administration of octreotide and methylglucamine diatrizoate accelerates resolution of small bowel obstruction by a specific therapeutic effect and is safe for the older persons.

Accumulating evidence demonstrates that resveratrol, a natural polyphenolic compound extracted from plants, inhibit inflammation when administered. It has direct effects on suppression of platelet coagulation and cytokines production in many experimental models. Because microcirculation occlusion and cytokines over-production is involved in many diseases such as acute pancreatitis (AP), the discovery of resveratrol as platelet and cytokines inhibitors has shed light on the treatment of AP, which still has significant mortality and morbidity. It is anticipated that this natural polyphenol could serve as a therapeutic compound in managing AP through different pathways.

AIM: To investigate the effect of ethylene diamine tetraacetic acid (EDTA) on proliferation of rat colonic cells. METHODS: EDTA was administered into Wistar rats, carcinogenesis induced by 1,2-dimethylhydrazine (DMH) in rats was studied with immunohistochemistry. RESULTS: Marked regional differences in cell proliferation were found in all groups. In EDTA-treated animals, total labelling indexes in both proximal (10.00

目的 探讨白藜芦醇对大鼠重症急性胰腺炎炎症介质的作用。方法 应用逆行胰胆管穿刺注射牛黄胆酸钠制 备重症急性胰腺炎大鼠模型。90只大鼠随机分为假手术组、重症急性胰腺炎模型组（sAP）、白藜芦醇治疗组Ⅰ（RESl，5mg/kg）、白藜芦醇治疗组II(REs2，10mg/kg)、白藜芦醇治疗组Ⅲ（REs3，20mg/kg）等5组，每组18只。术后3、6、12h各剖杀6只，观察重症急性胰腺炎大鼠模型腹水的性质、量，测定血清肿瘤坏死因子、白细胞介素6的水平，观察治疗组和模型组生存率的变化。结果 白藜芦醇治疗组与重症急性胰腺炎模型组相比，血清中肿瘤坏死因子、白细胞介素6的水平明显下降，死亡率降低，腹水量减少（P<0.05）。结论 白藜芦醇降低重症急性胰腺炎大鼠死亡率，减少腹水量可能与抑制血清肿瘤坏死因子及白细胞介素6的水平有关。

目的 了解近年来老年直肠癌临床特征及治疗的变迁。方法 回顾性分析10年间313例老年直肠癌患者的临床特征及治疗情况，对比第一个5年和第二个5年的临床特征及治疗方法的变迁。结果 发病年龄后延，误诊率降低，早期病例增多；Dixon手术增多，辅助治疗由简单变为综合治疗方法；5年生存率明显提高，术后的复发率明显减低。结论 老年直肠癌发病年龄后延，误诊率降低，早期病例逐渐增多；治疗上更趋有效、合理

目的 通过体外诱导高效特异的抗肝癌细胞系免疫反应，制备一种以树突状细胞（Dc）为基础的肝癌疫苗。方法 分离人外周血单核细胞，经IL-4和GM-CSF联合刺激诱导DC分化。培养第4天，DC用人肝癌细胞系SMMC-7721的冻融抗原致敏。培养第7天，将肝癌冻融抗原致敏的Dc和未经肝癌冻融抗原致敏的DC分别与T淋巴细胞混合培养24h作为效应细胞，以人SMMC-7721肝癌细胞、MCF-7乳腺癌细胞和PC-3前列腺癌细胞作为靶细胞，用MTT法检测细胞毒活性。结果 经肝癌冻融抗原致敏的DC对SMMC7721细胞有高效而特异的杀伤活性，对其他肿瘤细胞系也有一定的杀伤活性，但无明显特异性；未经肝癌冻融抗原致敏的DC对3种肿瘤细胞系均有一定的杀伤活性，但无明显特异性；各组效应细胞对靶细胞的杀伤率随效靶比(EC/TC)的升高而增强。结论 以肝癌细胞冻融抗原冲击致敏的DC刺激T淋巴细胞增殖在体外可诱导产生高效特异性的抗肝癌免疫反应，为肝癌的主动特异性免疫治疗提供了可靠的理论依据。