Objectives: To assess the eficacy of Fuhuang Tablets in treating internal hemorrhoid hemor-rhage and discussing the design and quality control of clinical trials of traditional Chinese medicine. Methods: According to two-center, random ized, bIinded and controlled study. 144 patients with internaI hemorrhoids were divided into 2 groups. Seventy-two patients were treated with Fuhuang Tablets (4 tablets t. i. d. per OS) and the other 72 patients were treated with Zhining Tablets (4 tablets t. i. d. per os. Symptoms and signs of the patients were recorded and evaluated at the third and seventh day of treatment respectively. Results: At the third day of treatment, the overall response rates of Fuhuang Tablets-treated group and ZhiningTablets. treated group were 58.57% and 27.78% respectively, with statistic diference between the two groups (P<0.05). At the seventh day of treatment. the overall response rates of Fuhuang Tablets. treated group and Zhining Tablets-treated group were 9 1.43% and 81.94% respectively. with no statistic diference between the two groups. The laboratory test results and Iife signs of the 1 44 patients were normal before and after the treatment. Conclusion: Fuhuang Tablets are efective and safe in treating internal hemorrhoid hemorrhage.

目的：探讨温肾健脾中药对慢性创面愈合的影响及可能作用机制。方法：采用大鼠背部开放性创面模型，用肌注氢化可的松的方法造成慢性难愈性创面，以辛葡康为阳性对照药，应用免疫组化、流式细胞术等方法，观察创面愈合时间、新生上皮宽度、肉芽组织形态学变化、肉芽组织细胞周期、表皮生长因子（epidermal growth factor, EGF）、转化生长因子p1（transforming growth factor-pl，TGF-p1）及纤维连接蛋白（fibronectin, FN）等指标。结果：温肾健脾方治疗组与辛葡康对照组平均创面愈合时间分别为（17.0±1.9）和（18.8±1.9）d，较模型组及空白组明显缩短（P<0.05）；治疗14d后，治疗组及对照组新生上皮宽度分别（3.73±0.19）和（3.21±0.15）mm，较模型组及空白组明显增宽（P<0.05）；治疗组新生毛细血管丰富，成纤维细胞数量多，而对照组、模型组及空白组新生毛细血管及成纤维细胞数量均较治疗组明显减少（P<0.05）；治疗组S期细胞比例较对照组、模型组及空白组明显提高（P<0.05）；治疗组及对照组与模型组及空白组比较，EGF、TGF-B1、FN蛋白表达均增强（P<0.05）。结论：温肾健脾方有促进大鼠慢性难愈创面修复的作用，其机制与调节细胞周期，上调EGF、TGF-B细胞因子蛋白表达水平，促进间质FN 的表达有关。

采用隧道式拖线加内口切挂术治疗后位马蹄型肛瘘46例，44例为一次性治愈，2例经一次扩创后治愈，平均疗程（26±3）天。