董常明
个性化签名
- 姓名:董常明
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学术头衔:
教育部“新世纪优秀人才支持计划”入选者, 博士生导师
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学科领域:
高分子化学
- 研究兴趣:
董常明博士,生于1972年9月,教授,博士生导师。2001年7月获北京大学高分子化学与物理博士学位;2002/03 ~ 2003/12在美国艾默蕾大学(Emory University)医学院外科系与生物医学工程系生物材料与组织工程研究室从事博士后研究工作;2003年12月加入上海交通大学化学化工学院高分子科学与工程系,2004年8月任副教授,2009年1月任教授。2008年入选教育部“新世纪优秀人才支持计划”和上海交通大学“晨星青年学者奖励计划”。目前主持国家自然科学基金面上项目1项、已主持完成国家自然科学基金面上项目2项、上海市重大基础研究项目1项、以及教育部留学回国基金1项,曾参与973国家重点基础研究发展规划项目“生物医用材料基本科学问题的研究”、国家自然科学基金重点项目、及美国NIH等多项重要研究课题。目前,已在Macromolecules、Biomacromolecules、Biomaterials、J.Control. Rel.、J.Polym.Sci.Polym. Chem.、Polymer等国际高分子、生物材料领域的核心学术期刊发表论文40余篇,其中以第一作者和通讯作者发表IF>3论文28篇,论文被国际同行他引逾300次。
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15
董常明, Chang-Ming Dong, † Kun-Yuan Qiu, *, † Zhong-Wei Gu, ‡ and Xin-De Feng†
Macromolecules 2001, 34, 4691-4696,-0001,():
-1年11月30日
Two types of three-arm or four-arm star-shaped hydroxy-terminated poly(-caprolactone) (PCL) were successfully synthesized via the ring-opening polymerization of caprolactone (CL) with multifunctional initiator, such as trimethylolpropane (TMP) or pentaerythritol (PTOL), and stannous octoate (SnOct2) catalyst in bulk at 110℃. The number-average molecular weight of PCL is proportional to the molar ratio of monomer to initiator. 1H NMR spectroscopy of the resulting PCL indicates that it contains a primary hydroxy end group in each arm. The star-shaped PCL with hydroxy end groups can be used as a macroinitiator for block copolymerization with DL-3-methylglycolide (MG) using SnOctcatalyst in bulk at 115℃. 1H NMR spectra of the resulting block copolymers show that the molecular weights and the unit compositions of the block copolymers were controlled by the molar ratios of MG monomer to hydroxy groups of PCL and MG to CL in feed, respectively. Moreover, the molecular weights of the resulting block copolymers linearly increased with the increase of the molar ratios of MG to CL in feed. The molecular weight distributions of the block copolymers were rather narrow (Mw/Mn) 1.09-1.26). 13C NMR spectra of the resulting block copolymers clearly show their diblock structures, that is, PCL as the first block and poly(DL-lactic acid-alt-glycolic acid) (DL-PLGA50) with alternating structures of lactyl and glycolyl units as the second block. Therefore, two types of three-arm or four-arm star-shaped diblock copolyesters comprising the first block PCL and the second block DL-PLGA50 were successfully synthesized via the sequential ring-opening polymerization of CL with multifunctional initiator and Snoctcatalyst and then followed by copolymerization with MG.
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【期刊论文】Facile Synthesis of Chain-End Functionalized Glycopolymers for Site-Specific Bioconjugation
董常明, Sijian Hou, † Xue-Long Sun, *, † Chang-Ming Dong, † and Elliot L. Chaikof*, †, ‡
Bioconjugate Chem. 2004, 15, 954-959,-0001,():
-1年11月30日
A series of derivatized arylamine initiators were used to generate chain-end functionalized glycopolymers by cyanoxyl-mediated free-radical polymerization. Significant features of this strategy include the capacity to produce polymers of low polydispersity (PDI < 1.5) under aqueous conditions using unprotected monomers bearing a wide range of functional groups. In addition, the presence of a phenyl ring simplifies calculation of polymer saccharide content and molar mass by 1H NMR. It is particularly noteworthy, however, that derivatized arylamine initiators in conjunction with the presence of a terminal cyanate group provide a convenient approach for synthesizing polymers with a variety of distinct functional groups at R and ö chain ends. In the process, the capacity to label glycopolymers or otherwise conjugate them to proteins or other molecules is greatly enhanced.
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【期刊论文】Synthesis and Characterization of Glycopolymer-Polypeptide Triblock Copolymers
董常明, Chang-Ming Dong, † Xue-Long Sun, † Keith M. Faucher, † Robert P. Apkarian, ‡ and Elliot L. Chaikof*, †, §
Biomacromolecules 2004, 5, 224-231,-0001,():
-1年11月30日
Glycopolymer-polypeptide triblock copolymers of the structure, poly(L-alanine)-b-poly(2-cryloyloxyethyllactoside)-b-poly(L-alanine)(AGA), have been synthesized by sequential atom transfer radical polymerization (ATRP) and ring-opening polymerization (ROP). Controlled free radical polymerization of 2-O-acryloyloxyethoxyl-(2,3,4,6-tetra-O-acetyl-â-D-galactopyranosyl)-(1-4)-2,3,6-tri-O-acetyl-â-D-glucopyranoside (AEL) by ATRP with a dibromoxylene (DBX)/CuBr/bipy complex system was used to generate a central glycopolymer block. Telechelic glycopolymers with diamino end groups were obtained by end group transformation and subsequently used as macroinitiators for ROP of L-alanine N-carboxyanhydride monomers (Ala-NCA). Gel permeation chromatography (GPC) and nuclear magnetic resonance (NMR) spectroscopy analysis demonstrated that copolymer molecular weight and composition were controlled by both the molar ratios of the Ala-NCA monomer to macroinitiator and monomer conversion and exhibited a narrow distribution (Mw/Mn) 1.06-1.26). FT-IR spectroscopy of triblock copolymers revealed that the ratio of R-helix/â-sheet increased with poly(L-alanine) block length. Of note, transmission electron microscopy (TEM) demonstrated that selected amphiphilic glycopolymer-polypeptide triblock copolymers self-assemble in aqueous solution to form nearly spherical aggregates of several hundreds nanometer in diameter. Significantly, the sequential application of ATRP and ROP techniques provides an effective method for producing triblock copolymers with a central glycopolymer block and flanking polypeptide blocks of defined architecture, controlled molecular weight, and low polydispersity.
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【期刊论文】Photomediated crosslinking of C6-cinnamate derivatized type I collagen
董常明, Chang-Ming Dong a, b, Xiaoyi Wu b, Jeffrey Caves b, Shyam S. Rele b, Benjamin S. Thomasb, Elliot L. Chaikof b.c.*
Biomaterials 26(2005)4041-4049,-0001,():
-1年11月30日
Synthesis and characterization of cinnamated Type I collagen and its related mechanical properties after photomediated crosslinking were investigated in detail. Using an EDC/NHS conjugation method, collagen was chemically modified to incorporate a photosensitive cinnamate moiety. The cinnamated collagen was fully characterized by 1H NMR, UV-vis, and circular dichroism (CD) spectroscopy, as well as by rheological and mechanical analyses. Cinnamated collagens with varying degrees of derivatization retained collagen triple helical structure. The rheological spectra of collagen solutions demonstrate that the storage modulus decreases with increasing cinnamate content, owing to a decrease in physical crosslinking. The kinetics of the crosslinking process in both hydrated gels and dry films were monitored by UV-vis spectroscopy and confirmed that crosslinking was complete within 60 min of irradiation. The uniaxial stress-strain behavior of crosslinked collagen films, including Young's modulus and ultimate tensile strength, was comparable to values reported for glutaraldehyde-crosslinked monomeric collagen films. These data demonstrate that derivatization of collagen with photosensitive cinnamate moieties provides a facile route for solid-state crosslinking, thereby improving the mechanical properties of collagen and enhancing the potential applicability of collagen-based materials in tissue engineering and drug delivery.
Collagen, Crosslinking, Photocrosslinkable, Photodimerizable, Cinnamate, Blood vessel
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董常明, Jing-Liang Wang, Chang-Ming Dong*
Polymer 47(2006)3218-3228,-0001,():
-1年11月30日
Both well defined star-shaped poly(3-caprolactone) having four arms (4sPCL) and six arms (6sPCL) and linear PCL having one arm (LPCL) and two arms (2LPCL) were synthesized and then used for the investigation of physical properties, isothermal and nonisothermal crystallization kinetics, and spherulitic growth. The maximal melting point, the cold crystallization temperature, and the degree of crystallinity of these PCL polymers decrease with the increasing number of polymer arms, and they have similar crystalline structure. The isothermal crystallization rate constant (K) of these PCL polymers is in the order of K2LPCLOKLPCLOK4sPCLOK6sPCL. Notably, the K of linear PCL decreases with the increasing molecular weight of polymer while that of star-shaped PCL inversely increases. The variation trend of K over the number of polymer arms or the molecular weight of polymer is consistent with the analyses of both nonisothermal crystallization kinetics and the spherulitic growth rate. These results indicate that both the number of polymer arms and the molecular weight of polymer mainly controlled the isothermal and nonisothermal crystallization rate constants, the spherulitic growth rate, and the spherulitic morphology of these PCL polymers.
Poly(, caprolactone), with different arms, Crystallization kinetics, Spherulitic growth
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董常明, Hao Feng and Chang-Ming Dong*
Biomacromolecules 2006, 7, 3069-3075,-0001,():
-1年11月30日
Biodegradable chitosan-graft-poly(L-lactide)(CS-g-PLLA) hybrid amphiphiles were prepared through direct grafting of a PLLA precursor to the backbone of CS. The average number of PLLA grafts per CS could be adjusted by the feed ratio of PLLA to CS, and it varied from 1.3 to 16.8. Moreover, both the crystallization rate and degree of crystallization of PLLA grafts with these graft copolymers could be adjusted by the chain length of PLLA and the number of PLLA grafts per CS, respectively. Meanwhile, CS-g-PLLA exhibited good solubility in some nonpolar and polar organic solvents compared with the original CS. Furthermore, self-assembled nanoparticles could be generated by direct injection of these graft copolymer solutions into distilled water, and their critical aggregation concentration decreased with increasing number of PLLA grafts per CS. The average size of the nanoparticles (25-103nm) could be adjusted through the graft copolymer composition and the graft copolymer concentration, which was very different from the observations in ordinary PLLA-b- poly(ethylene oxide) amphiphiles. Significantly, this will provide a convenient method not only to combine the bioactive functions of CS with the good mechanical properties of biodegradable polymers, but also to generate nanoparticles with adjustable sizes for targeted drug release.
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董常明, Xiao-Hui Dai, †, ‡ Chang-Ming Dong, *, † Huan-Bao Fa, § Deyue Yan, † and Yen Wei
Biomacromolecules 2006, 7, 3527-3533,-0001,():
-1年11月30日
Star-shaped porphyrin-cored poly(-caprolactone)(SPPCL) was synthesized using a tetrahydroxyethyl-terminated porphyrin as a core initiator and stannous octoate as a catalyst in bulk at 120℃. The molecular weight of assynthesized polymer could be adjusted linearly by controlling the molar ratio of caprolactone to porphyrin core initiator, and the molecular weight distribution was reasonably narrow. Supramolecular polypseudorotaxanes were prepared by inclusion complexation of SPPCL with R-cyclodextrin (R-CD) and thoroughly characterized by means of FT-IR, 1H NMR, 13C CP/MAS NMR, DSC, TGA, and WAXD. The results demonstrated that the porphyrincored polypseudorotaxanes formed through R-CD molecules threading onto the branch chains of star-shaped SPPCL polymers, and they had a channel-type crystalline structure. Meanwhile, the original crystallization of SPPCL polymers within the polypseudorotaxanes was completely suppressed in the R-CD cavities. Moreover, inclusion complexation between SPPCL and R-CD enhanced the thermal stability of both the guest SPPCL polymers and the host R-CD. Furthermore, both the SPPCL polymers and the polypseudorotaxanes showed similar fluorescent and UV-vis spectra compared with porphyrin core initiator. Consequently, this will not only provide potentially porphyrin-cored poly(-caprolactone) and its polypseudorotaxanes for photodynamic therapy but also improve the compatibility between poly(-caprolactone) and peptide drugs for drug delivery.
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董常明, Xiao-Hui Dai, †, ‡ Chang-Ming Dong, *, † and Deyue Yan†
J. Phys. Chem. B 2008, 112, 3644-3652,-0001,():
-1年11月30日
A new class of supramolecular and biomimetic glycopolymer/poly(-caprolactone)-based polypseudorotaxane/glycopolymer triblock copolymers (poly(D-gluconamidoethyl methacrylate)-PPR-poly(D-gluconamidoethyl methacrylate), PGAMA-PPR-PGAMA), exhibiting controlled molecular weights and low polydispersities, was synthesized by the combination of ring-opening polymerization of-caprolactone, supramolecular inclusion reaction, and direct atom transfer radical polymerization (ATRP) of unprotected D-gluconamidoethyl methacrylate (GAMA) glycomonomer. The PPR macroinitiator for ATRP was prepared by the inclusion complexation of biodegradable poly(-caprolactone) (PCL) with R-cyclodextrin (R-CD), in which the crystalline PCL segments were included into the hydrophobic R-CD cavities and their crystallization was completely suppressed. Moreover, the self-assembled aggregates from these triblock copolymers have a hydrophilic glycopolymer shell and an oligosaccharide threaded polypseudorotaxane core, which changed from spherical micelles to vesicles with the decreasing weight fraction of glycopolymer segments. Furthermore, it was demonstrated that these triblock copolymers had specific biomolecular recognition with concanavalin A (Con A) in comparison with bovine serum albumin (BSA). To the best of our knowledge, this is the first report that describes the synthesis of supramolecular and biomimetic polypseudorotaxane/glycopolymer biohybrids and the fabrication of glucose-shelled and oligosaccharide-threaded polypseudorotaxane-cored aggregates. This hopefully provides a platform for targeted drug delivery and for studying the biomolecular recognition between sugar and lectin.
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董常明, Chong Hua, Song-Ming Peng, and Chang-Ming Dong*
Macromolecules 2008, 41, 6686-6695,-0001,():
-1年11月30日
A new class of linear-dendron-like poly(ε-caprolactone)-b-poly(ethylene oxide) (PCL-b-PEO) copolymers with unsymmetrical topology was synthesized via controlled ring-opening polymerization (ROP) of ε-caprolactone (CL) followed by a click conjugation with azide-terminated PEO (PEO-N3). The dendron-like PCL terminated with a clickable alkyne group (Dm-PCL, m) 0, 1, 2, and 3) was for the first time synthesized from the ROP of CL monomer using a propargyl focal point dendrons Dm with primary amine groups as the initiators and stannous octoate as catalyst in bulk at 130℃. Then, the linear-dendron-like Dm-PCL-b-PEO copolymers were obtained by the click conjugation of Dm-PCL with PEO-N3 using PMDETA/CuBr as catalyst in DMF solution at 35℃. Their molecular structures and physical properties were in detail characterized by FT-IR, NMR, MALLS-GPC, DSC, and WAXD. Both DLS and TEM analyses demonstrated that the biodegradable micelles and vesicles with different sizes (less than 100 nm) self-assembled from these Dm-PCL-b-PEO copolymers in aqueous solution, and both the PEO composition and the linear-dendron-like architecture of copolymers controlled the morphology and the average size of nanoparticles. To the best of our knowledge, this is the first report that describes the synthesis of linear-dendron-like PCL-b-PEO block copolymers via the combination of ROP and click chemistry. Consequently, this provides a versatile strategy not only for the synthesis of biodegradable and amphiphilic block copolymers with linear-dendron-like architecture but also for fabricating biocompatible nanoparticles with suitable size for controlled drug release.
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董常明, Song-Ming Peng, Yi Chen, Chong Hua, and Chang-Ming Dong*
Macromolecules 2009, 42, 104-113,-0001,():
-1年11月30日
Dendron-like poly(γ-benzyl-L-glutamate)/linear poly(ethylene oxide) block copolymers with both asymmetrical and symmetrical topologies (i.e., ABn type Dm-PBLG-b-PEO and BnABn type Dm-PBLG-b-PEOb- Dm-PBLG; n) 2m, m) 0, 1, 2, and 3; Dm are the propargyl focal point poly(amido amine) type dendrons having 2m terminal primary amine groups) were synthesized via the combination of ring-opening polymerization (ROP) of γ-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA) and click chemistry according to the "armfirst" and "core-first" strategies. In the arm-first method, the propargyl focal point dendrons Dm having 2m terminal primary amine groups were first used for initiating the ROP of BLG-NCA, generating "clickable" dendron-like Dm-PBLG homopolymers having 2m branches, which were then click conjugated with azide-terminated PEO (PEO-N3) to produce asymmetrical Dm-PBLG-b-PEO. In the core-first strategy, the propargyl focal point Dm was first click conjugated with PEO-N3 to generate primary amine-terminated PEO dendrons, which were further used as the macroinitiators for the ROP of BLG-NCA to produce the targeted copolymers with both asymmetrical and symmetrical topologies. Their molecular structures and physical properties were characterized in detail by FT-IR, NMR, gel permeation chromatography, differential scanning calorimetry, and wide-angle X-ray diffraction. Both spherical and wormlike micelles self-assembled from these Dm-PBLG-b-PEO copolymers in aqueous solution, and mainly the PBLG composition controlled the morphology of nanostructures.
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