刘宝华
擅长胃、大肠疾病外科治疗,乳腺、甲状腺疾病外科治疗。
个性化签名
- 姓名:刘宝华
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学术头衔:
博士生导师
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学科领域:
外科学
- 研究兴趣:擅长胃、大肠疾病外科治疗,乳腺、甲状腺疾病外科治疗。
刘宝华,普外科主任医师、教授、博士、博士生导师,现任第三军医大学大坪医院普通外科主任、中华医学会普通外科学会肛肠专委会委员、重庆市医学会普通外科专业委员会委员、重庆市抗癌协会胃癌专委会副主任委员、重庆市医学会营养专委会会委员、重庆市中西医结合学会肛肠专委会委员。第三军医大学学报编委。全军普通外科肛肠专委会委员。
擅长胃、大肠疾病外科治疗,乳腺、甲状腺疾病外科治疗。先后开展了全胃切除术后,直肠切除术后消化道重建及可控性会阴人造肛门研究;温热腹腔灌注化疗治疗胃、大肠肿瘤研究;盆底功能检测及便秘生物反馈治疗。先后参编、主编专著5部,发表论文50余篇,先后获得重庆市和军队科技成果二、三等奖共7项,第一作者两项。
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刘宝华, Bao-Hua Liu, Ping Mo, Sheng-Ben Zhang
,-0001,():
-1年11月30日
AIM: To study the effects of mu and kappa opioid receptor agonists and antagonists on the isolated colon strips of rats with cathartic colon. METHODS: Cathartic colon model was established by feeding rats with contact laxatives, and effects of mu and kappa opioid receptor agonists and antagonists on electricitystimulated contraction of isolated colon strips of rats with cathartic colon were observed. RESULTS: Compared with control group, exogenous mu and kappa agonists inhibited significantly electricity-stimulated contraction of strips of cathartic colon (8.50
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【期刊论文】Changes of mu and kappa opioid receptors in cathartic colon of rat
刘宝华, LIU Bao-hua, MO Ping, J Hou-jun, LI Chun-xue, ZHANG Sheng-ben
Journal of Medical Colleges of PLA 200419(5):282~284,-0001,():
-1年11月30日
To observe the changes of mu and kappa opioid receptors in the cathartic colon of rat,and to clarify that whether opioid receptors accounts for the occurrence of slow transit constipation(STC).Methods:The cathartic colon model of rat was made by feeding with laxatives.The activity of mu and kappa opioid receptors in the cathartic colon of rat was measured by radio-ligand binding assay,Results:Compared with the control group,the maximal binding capacity(Bmax)and affinity(Kd)of mu opioid receptor in cathartic colon group were significantly increased(207.00±22.90 fmoL/mg·p vs 82.00±14.23 fmol/mg·p.P<0.01;3.30±0.45 mmol/L vs 2.40±0.57 mmol/L,P<0.05).The maxi-mal binding capacity ofkappa opioid receptor also showed a great increase(957.00±102.41 fmol/mg·p vs 459.00±52.41 fmol/mg·p,P<0.01),but 13o significant diference of afinity was found between the two groups Conclusion:The mu and kappa opioid receptors may be involved in the functional disorders of cathartic colon,
cathartic colon, mu opioid receptor, kappa opioid receptor
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