李忠
1)昆虫行为调控剂的分子设计与合成研究,主要包含:昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等 绿色农药的创制;2)含硒化合物的设计合成及生物性能研究,主要包含:含硒除草剂、含硒植物生长调节剂的创制及生物性能研究。
个性化签名
- 姓名:李忠
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
-
学科领域:
岩土力学
- 研究兴趣:1)昆虫行为调控剂的分子设计与合成研究,主要包含:昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等 绿色农药的创制;2)含硒化合物的设计合成及生物性能研究,主要包含:含硒除草剂、含硒植物生长调节剂的创制及生物性能研究。
李忠,男,教授,博士生导师,华东理工大学药物化工研究所所长。1968年出生。2004年聘为博导,2003年被聘为教授,1998年被聘为副教授。1996年获华东理工大学精细化工专业工学博士学位,1993年获华东理工大学物理化学专业理学硕士学位,1990年获华东理工大学应用化学专业工学学士学位。1999-2001年在日本工业技术研究院从事ITIT及AIST博士后基金的研究。
作为课题副组长承担国家“973”计划项目一项,作为项目负责人承担了国家“863”高科技攻关项目三项、上海市重大攻关及上海市重点攻关等项目的研究。在J. Am. Chem. Soc.,Synthesis , J. Fluorine Chem.等国际学术期刊上外发表论文二十余篇。2002年任上海市科技预见专家,宝钢化工集团公司咨询专家。
研究方向:1)昆虫行为调控剂的分子设计与合成研究,主要包含:昆虫生长调节剂、昆虫飞行调控剂、新烟碱杀虫剂等 绿色农药的创制;2)含硒化合物的设计合成及生物性能研究,主要包含:含硒除草剂、含硒植物生长调节剂的创制及生物性能研究。
获奖成果:1.“含氟精细有机化学品的氟盐氟化制备技术”,2002教育部科技进步一等奖(8);2.“芳香杂环及含氟仿生农药的分子设计、化学制备及构效关系”,2003教育部科技进步一等奖(5)。
-
主页访问
1431
-
关注数
0
-
成果阅读
430
-
成果数
9
李忠, XUSHENG SHAO, ZHIPING XU, XIANFENG ZHAO, XIAOYONG XU, * LIMING TAO, ZHONG LI, * AND XUHONG QIAN
J. Agric. Food Chem. XXXX, XXX, 000-000 A,-0001,():
-1年11月30日
A series of hexahydroimidazo[1,2-a]pyridine derivatives were designed and synthesized through aza-Diels-Alder reactions and evaluated for insecticidal activities. Compounds 6a-d with endoconformation were endowed with excellent insecticidal activities against cowpea aphid (Aphis craccivora) and armyworm (Pseudaletia separata Walker), whereas exo-compounds 7a-d showed only low activities against cowpea aphid. The difference in activities between the endo- and exoconformations indicated that conformation was the determinant of life or death of the insects for these compounds.
Diels-Alder reaction, insecticide, conformation, activities
-
67浏览
-
0点赞
-
0收藏
-
0分享
-
142下载
-
0评论
-
引用
【期刊论文】Enantiocontrolled Synthesis of (-)-9-epi-Pentazocine and (-)-Aphanorphine
李忠, Xiaobao Yang, †, ‡ Hongbin Zhai, *, † and Zhong Li*, ‡
Org. Lett., Vol. 10, No.12, 2008,-0001,():
-1年11月30日
We have developed novel asymmetric routes to (-)-9-epi-pentazocine and (-)-aphanorphine from a D-tyrosine derivative. The tricyclic frameworks of (-)-9-epi-pentazocine and (-)-aphanorphine were assembled stereoselectively via intramolecular Friedel-Crafts reaction of the corresponding bicyclic precursors, generated with titanium-promoted enyne cyclization and indium-initiated atom-transfer radical cyclization, respectively.
-
35浏览
-
0点赞
-
0收藏
-
0分享
-
344下载
-
0评论
-
引用
李忠, Shaoyong Ke, Zhong Li, Xuhong Qian *
Bioorganic & Medicinal Chemistry 16(2008)7565-7572,-0001,():
-1年11月30日
A new series of 1,3,4-oxadiazole-3(2H)-carboxamide derivatives have been synthesized by direct heterocyclization reaction of substituted benzoylisocyanate with various aroylhydrazones as novel monoamine oxidase inhibitors (MAOIs). The target molecules have been identified on the basis of satisfactory analytical and spectra (IR, 1H NMR, 13C NMR, and HR-MS) data. The newly synthesized compounds were evaluated for their MAO inhibitory activity by kynuramine fluorimetric assay method. The preliminary results showed that most of the compounds have moderate inhibitory activities toward MAO at the concentration of 10-5-10-3 M. This work may provide a novel class of lead compounds with potential MAO inhibitions for further optimization.
1,, 3,, 4-Oxadiazole-3(, 2H), -carboxamide Heterocycle MAO inhibitor Urea
-
51浏览
-
0点赞
-
0收藏
-
0分享
-
142下载
-
0评论
-
引用
李忠, Chuanxiang Liu, Xuhong Qian, * Guangqiang Sun, Liwei Zhao and Zhong Li*
New J. Chem., 2008, 32, 472-476,-0001,():
-1年11月30日
We have developed a chromogenic and fluorescent chemodosimeter 3, based on a novel anioncatalyzed intramolecular hydrogen transfer, which displayed drastic changes in UV-Vis absorption as well as fluorescence emission intensities showing selectively for F- over other anions.
-
32浏览
-
0点赞
-
0收藏
-
0分享
-
118下载
-
0评论
-
引用
李忠, Chuanxiang Liu, Xuhong Qian *, Jiaobing Wang, Zhong Li *
Tetrahedron Letters 49(2008)1087-1090,-0001,():
-1年11月30日
Strong electron-deficient heterocycles of acetyl Fipronil (F3) was designed and synthesized, its ability for anion recognition was investigated by UV and NMR analyses. This novel Fipronil-based receptor F3 shows strong binding affinity with acetate (P107 M1), phosphate or fluoride ion through efficient deprotonation. In addition, its interaction with chloride anion or other weak base anions through stable intermolecular H-bonding was also reported.
-
42浏览
-
0点赞
-
0收藏
-
0分享
-
138下载
-
0评论
-
引用
李忠, Yanli Wang, Jiagao Cheng, Xuhong Qian* and Zhong Li*
Bioorganic & Medicinal Chemistry 15(2007)2624-2630,-0001,():
-1年11月30日
Neonicotinoid insecticides show selective actions on insect nicotinic acetylcholine receptor (nAChR). Two key residues (Trp and Arg/Lys) have been identified as contributing to the neonicotinois binding. To investigate the selective mechanism, a computational model was set up to simulate the interaction between residues (Trp and Arg) of insect nAChR and neonicotinoids by quantum chemistry method. Three analogues of neonicotinoid derivatives without the chloropyridinyl moiety and 3-methyl-indole (3MI), guanidinium (Gua) were used to mimic the neonicotinoids and the side chain of key residues Trp and Arg accordingly. Interaction features of 3MI-analogues, analogues-Gua and 3MI-analogues -Gua complexes were analyzed comparatively. Hydrogen bonding between the nitro group of analogues and Gua was found to be the most important for binding. Moreover, the cooperative p-p interaction between analogues and the indole ring, which is strengthened by the existence of Gua, also contributes to the binding. The alternative binding model of neonicotinoids proposed here, although slightly different from others, might be close to the actual.
Neonicotinoids, Nicotinic acetylcholine receptor, Binding model.,
-
53浏览
-
0点赞
-
0收藏
-
0分享
-
63下载
-
0评论
-
引用
李忠, Feng Fanb, Zhong Lib*, Xiaoyong Xuc and Xuhong Qiana*
QSAR Comb. Sci. 26, 2007, No.6, 737-743,-0001,():
-1年11月30日
Aggregation state of bioactive compounds plays a key role in its bio-interactive procedure. In this paper, based on the structural information of dimers, the simplest model of aggregation state, classical QSAR, was used for the investigation of the relationship between aggregation state and bioactivity. Aided by the template of crystal structure of Teflubenzuron, two dimer descriptors of DE and DRg which could describe parts of the aggregation state characters were used to establish the models. QSAR research implicates that the bioactivity may strongly depend on the molecular aggregation state.
Aggregation state,, Bio-interact procedure,, Crystal,, Dimer,, QSAR
-
41浏览
-
0点赞
-
0收藏
-
0分享
-
62下载
-
0评论
-
引用
【期刊论文】Syntheses and Biological Activities of Octahydro-1H-cyclopenta[d]pyrimidine Derivatives
李忠, ZHONGZHEN TIAN, ZHAOXING JIANG, ZHONG LI, * GONGHUA SONG, * AND QINGCHUN HUANG
J. Agric. Food Chem. 2007, 55, 143-147,-0001,():
-1年11月30日
Various nitromethylene derivatives were synthesized regioselectively. Compounds 8a-f were obtained by the reaction of 1-((5-chloropyridin-2-yl)methyl)-2-(nitromethylene)-octahydro-1H-cyclopenta[d]-pyrimidine (3) with primary amines and formaldehyde. The synthesized compounds were identified by 1H NMR, HRMS (EI), and IR, and preliminary bioassays indicated that most of them showed moderate insecticidal activities against Aphis craccivora. The relationship between hydrophobicity and biological activity was also discussed.
Nitromethylene derivatives, synthesis, regioselective, biological activity, hydrophobicity
-
43浏览
-
0点赞
-
0收藏
-
0分享
-
83下载
-
0评论
-
引用
李忠, ZHONGZHEN TIAN, XUSHENG SHAO, ZHONG LI, * XUHONG QIAN, * AND QINGCHUN HUANG
J. Agric. Food Chem. 2007, 55, 2288-2292,-0001,():
-1年11月30日
To keep the nitro group in the cis position, a series of nitromethylene neonicotinoids containing a tetrahydropyridine ring with exo-ring ether modifications were designed and synthesized. All of the compounds were characterized and confirmed by 1H NMR, high-resolution mass spectroscopy, elemental analysis, and IR. The bioassay tests showed that some of them exhibited good insecticidal activities against pea aphids. On the basis of 10 nitromethylene derivatives, the quantitative structurebioactivity relationship (QSAR) was analyzed and established. The results suggested that AlogP98 and Dipole_Mopac might be the important parameters related with biological activities.
Nitromethylene, tetrahydropyridine, cis position, QSAR
-
66浏览
-
0点赞
-
0收藏
-
0分享
-
63下载
-
0评论
-
引用