邢婉丽
博士研究生 教授
清华大学 医学院生物医学工程系
生物芯片表面化学、芯片反应器件、微流体分离芯片、神经生物芯片和蛋白质免疫芯片系统
个性化签名
- 姓名:邢婉丽
- 目前身份:在职研究人员
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:高级-教授
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学科领域:
物理海洋学
- 研究兴趣:生物芯片表面化学、芯片反应器件、微流体分离芯片、神经生物芯片和蛋白质免疫芯片系统
邢婉丽,清华大学生命科学学院教授、清华大学医学院教授、 博士生导师、研究员、生物芯片北京国家工程研究中心常务副主任兼博奥生物公司技术副总裁。1990年本科毕业于南开大学化学系,1997年于南开大学化学系获理学博士学位,之后在军事医学科学院做博士后研究。
研究方向:1.研究开发基于生物芯片的感染性疾病病原体及耐药性检测产品,例如结核耐药检测芯片,呼吸道病原体,快速检测芯片。2.开设生物芯片理论及实验课程,以感染性疾诊治为基应用领域之一,面向本科生进行授课。3.组织制定感染性疾病诊治相关生物芯片国家标准。已获生物芯片相关专利16项,其中2项美国专利,14项中国专利;已发表研究论文50多篇,主编出版生物芯片论著4部(英文2部,中文2部);已作为负责人承担并完成了多项生物芯片相关的863、973、国家自然科学基金等研究课题,其中“系统化生物芯片与相关仪器设备的研制及应用”获2007年国家技术发明二等奖;入选2007年度教育部新世纪优秀人才支持计划。
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邢婉丽, Guangxin Xiang a, b, c, Liangbin Pan a, Lihua Huange, Zhongyao Yu e, Xindong Songa, Jing Chenga, d, Wanli Xing a, ∗, Yuxiang Zhoua
Biosensors and Bioelectronics 22(2007)2478-2484,-0001,():
-1年11月30日
Microelectrode arrays (MEAs) provide a means to investigate the electrophysiological behavior of neuronal systems through the measurements from neuronal culture preparations. Changes in activity patterns of neuronal networks are usually detected by applying neural chemicals. Because of the difficulties of fabricating the arrays, and the delicate and less reliable properties of cortical neurons, MEA-based systems with cortical neuronal networks for neurophamacological applications are technically difficult, therefore restricting their utility. Here, we report a new approach to the development of such MEA-based system with sensitive and durable MEAs conveniently fabricated and the culture conditions optimized. Upon growth differentiation, cortical neurons, cultured directly on MEAs, reach a developmentally stable and reliable activity state. With this system, we monitored the global spontaneous activities of neuronal networks and demonstrated the fine discrimination for specific substances and unique property of cortical neurons, which validated both the applicability and necessity of such system in pharmacological bioassay.
Microelectrode array, Neuropharmacology, Cortical neurons, Microfabrication, Electrophysiology, Spontaneous activity
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【期刊论文】Portable fiber-optic immunosensor for detection of methsulfuron methyl
邢婉丽, Wan-Li Xing a, *, Li-Ren Ma b, Zhong-Hua Jiang b, Fu-Huan Cao a, Ming-Hong Jia c
Talanta 52(2000)879-883,-0001,():
-1年11月30日
This fiber optic sensor, based on competitive immunoreactions between coating-haptens and free haptens in solutions with corresponding antibodies, was developed to determine the concentration of the free hapten, methsulfuron-methyl. The ovalbumin (OVA)-methsulfuron-methyl conjugate was immobilized on a microscope slide. Horseradish peroxidase (HRP) labeled goat anti-rabbit IgG was used to generate an optical signal. The portable optical device consisted of a 0.25-W tungsten-halogen light source and a photosensitive diode detector. A typical competitive-binding calibration curve was seen between 0.3 and 100 ng:ml of methsulfuron-methyl. The detection limit for methsulfuron-methyl was 0.1 ng/ml.
Fiber-optic biosensor, Immunosensor, Methsulfuron-methyl, Pesticide detection
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