占秀安
动物营养与(肉质,减排)调控;新型饲料添加剂开发。
个性化签名
- 姓名:占秀安
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学术头衔:
教育部“新世纪优秀人才支持计划”入选者, 博士生导师
- 职称:-
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学科领域:
动物营养学
- 研究兴趣:动物营养与(肉质,减排)调控;新型饲料添加剂开发。
占秀安 研究员,博导,副所长。
教育背景与工作简历:2007.12~至今 浙江大学动物科学学院 研究员;2007.04~2007.12 农业部畜牧司行业发展处 副调研员;2002.12~2007.12 浙江大学动物科学学院 副研究员;2001.03~2005.03 浙江大学动物科学学院 博士研究生;1998.09~2002.12 浙江大学动物科学学院 讲师;1996.08~1998.09 浙江农业大学饲料科学研究所 助教;1993.09~1996.07 浙江农业大学饲料科学研究所 硕士研究生;1990.08~1993.08 杭州市农业科学研究院 技术员;1985.09~1990.07 浙江农业大学畜牧兽医系 本科生。
学术兼职:生物饲料安全与污染防控国家工程实验室副主任;浙江省饲料产业科技创新服务平台副主任;浙江省动物营养与保健品学会理事;浙江省饲料工业标准化技术委员会委员。
所获荣誉与主要奖励:2008年国家现代农业产业技术体系岗位科学家;2007年教育部新世纪优秀人才;2006年浙江省151人才第二层次;2005年浙江省151人才第三层次;2001年杭州市131人才第一层次;2007年浙江省科技进步三等奖(第二);2004年浙江省科技进步二等奖(第二);2003年浙江省教委科技进步一等奖(第二);2001年国家科技进步二等奖(第八);2001年浙江省科技进步二等奖(第二);2000年浙江省农业科技进步一等奖(第二);2000年浙江省科技进步二等奖(第七);1998年浙江省科技进步二等奖(第七)。
研究领域:动物营养与(肉质,减排)调控;新型饲料添加剂开发。
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占秀安, XiuAn Zhana, *, Min Wang b, RuQian Zhaoc, WeiFeng Li a, ZiRong Xua
Animal Feed Science and Technology 132(2007)202-211,-0001,():
-1年11月30日
The experiment was conducted to study the effects of different selenium source on selenium distribution, loin quality and antioxidant status in finishing pigs. A total of 108 castrates (Duroc×Landrace×Yorkshire) at average body weight (BW) of 60 kg were allotted to three treatments, each of which was replicated three times with 12 pigs per replicate (four per pen). The control groups received the basal diet containing 0.045 mg Se/kg. A 0.3 mg Se/kg in forms of sodium selenite or selenomethionine was added to the basal diet for the experimental groups. The total test period was 40 d. Results showed that selenomethionine-treatment increased the Hunter a (redness) value of meat color during 45 min, 8 and 16 h measurement period (P<0.05) and decreased the drip loss of loin muscle during 8 and 16 h measurement period (P<0.05), while sodium selenite-treatment only elevated the Hunter a value of meat color during 0.75 h measurement period (P<0.05) and had no significant effects on drip loss of loin muscle tissues. Both selenomethionine and sodium selenite-treatment increased the Se content in serum, muscle, liver, pancreas and kidney tissue (P<0.05), the level was substantially higher in muscle, liver and pancreas (P<0.05) in the selenomethionine treated group. In addition, both selenomethionine and sodium selenite-treatment increased glutathione peroxidase (GSH-Px) activity (P<0.05) and decreased the malondialdehyde (MDA) content in the liver and muscle (P<0.05) when compared with control group, but the level of magnitude was higher when selenomethionine was fed. The present study suggests that compared with sodium selenite, selenomethionine is more effective in depositing Se in tissues, enhances the antioxidant status, thus decreasing the volume of drip loss and stabilizing the meat color.
Se, Selenomethionine, Sodium selenite, Pig, Meat color, Drip loss, GSH-Px, MDA
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【期刊论文】TOXIC EFFECTS OF FLUORIDE ON KIDNEY FUNCTION AND HISTOLOGICAL STRUCTURE IN YOUNG PIGS
占秀安, Xiu-An Zhan, a Min Wang, a, b Zi-Rong Xu, a Jian-Xin Lia Hangzhou, China
Research report Fluoride 39(1)22-26 January-March 2006,-0001,():
-1年11月30日
The effects of chronic fluoride exposure on kidney integrity and histological structure, along with effects on associated enzymes and metabolite changes, were investigated in young pigs. Twenty-four crossbred barrows (Duroc×Landrace×Yorkshire) about 50 days old were randomly divided into three groups of eight pigs each. Groups I, II, and III received the same basal diet additionally supplemented, respectively, with 0, 100, and 250 mg F–/kg (from NaF). Results obtained after 50 days indicated that supplemental fluoride-treatment caused severe renal histological changes as well as increased renal cell apoptosis. In kidney tissue, lactate dehydrogenenase (LDH) activity was significantly increased in group III, whereas alkaline phosphatase (AKP) activity was significantly decreased in group II as well as in group III. In the serum, significantly increased urea nitrogen (UN) was present in groups II and III, and the serum of group III had elevated creatinine (Cre) and decreased Na+. These findings show that chronic excessive fluoride exposure is deleterious to kidney structure and function of pigs.
Alkaline phosphatase, Creatinine, Fluoride, Kidney function, Kidney histology, Lactate dehydrogenenase, Serum sodium, Serum urea nitrogen, Young pigs.,
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【期刊论文】EFFECTS OF FLUORIDE ON GROWTH AND THYROID FUNCTION IN YOUNG PIGS
占秀安, Xiu-An Zhan, a Jian-Xin Li, Min Wang, Zi-Rong Xu Hangzhou, China
Research report Fluoride 39(2)95-100 April-June 2006,-0001,():
-1年11月30日
This study was undertaken to investigate the effects of fluoride on growth and thyroid function in young pigs. Three groups of eight crossbred barrows were exposed to 100, 250, and 400 mg F-/kg (from NaF) in their diets for 50 days. Compared to a control group of eight pigs, the average daily gain in weight was significantly reduced, and serum thyroxine (T4) and free thyroxine (FT4) levels also decreased significantly. On the other hand, the level of serum thyroid-stimulating hormone (TSH) was significantly increased, but no significant differences were observed in serum triiodothyronine (T3) and free triiodothyronine (FT3). The activity of Na/K-ATPase in the thyroid was significantly inhibited as well as thyroid peroxidase (TPO). The results suggest that excessive fluoride in the diet can cause growth depression and hypothyroxinemia in pigs. Accompanying thyroid lesions were attributed to fluoride acting as a TSH analogue in concert with elevated TSH levels.
Fluoride and growth, Growth depression, Hypothyroxinemia in pigs, Thyroid enzymes, Young pigs.,
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【期刊论文】EFFECTS OF FLUOROSIS ON LIPID PEROXIDATION AND ANTIOXIDANT SYSTEMS IN YOUNG PIGS
占秀安, Xiu-an Zhan, a Zi-rong Xu, a Jian-xin Li, a, b Min Wanga Hangzhou, China
Fluoride 2005; 38 (2): 157-161 Research report 157,-0001,():
-1年11月30日
This study was conducted to investigate effects of fluoride on lipid peroxidation and antioxidant systems in young pigs. Three groups of crossbred barrows about 50 days old were exposed to 100, 250, and 400 mg F–/kg (from NaF) in their diets for 50 days. Serum malondialdehyde (MDA) and nitric oxide (NO) levels were significantly increased, and the activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) were significantly decreased. In thyroid, liver, and kidney tissues, the MDA level was significantly increased, and SOD and GSH-Px activities were significantly decreased. These results suggest that fluoride induces excessive production of NO and reactive oxygen species (ROS), enhances lipid peroxidation, and disturbs the antioxidant system of pigs. Oxidative damage from oxidative stress could therefore be an important pathway for fluoride toxicity in soft tissues.
Catalase, Fluoride, Glutathione peroxidase, Malondialdehyde, Nitric oxide, Oxidative stress, Reactive oxygen species, Superoxide dismutase, Young pigs.,
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【期刊论文】EFFECTS OF FLUORIDE ON PANCREATIC DIGESTIVE ENZYME ACTIVITIES AND ULTRASTRUCTURE IN YOUNG PIGS
占秀安, Xiu-an Zhan, a Jian-xin Li, a Zi-rong Xu, a Min Wanga Hangzhou, China
Fluoride 2005; 38 (3): 215-219 Research report 215,-0001,():
-1年11月30日
This study was conducted to investigate the effects of fluoride on pancreatic digestive enzyme activities and ultrastructure in young pigs. Three groups of crossbred barrows were exposed to 100, 250, and 400 mg F-/kg (from NaF) in their diets for 50 days. Compared to a control group, the activities of pancreatic lipase and protease (but not amylase) were significantly decreased. Pancreatic acinar cells showed markedly swollen mitochondria and loss of mitochondrial cristae. Endoplasmic reticulum (ER) was markedly dilated and its folds were irregular. These results indicate that excessive fluoride in the diet can inhibit pancreatic digestive enzyme activities and cause ultrastructural changes, which may lead to a series of biochemical and pathological abnormalities.
Digestive enzymes, Endoplasmic reticulum, Lipase, Mitochondria, Pancreatic acinar cells, Protease, Young pigs.,
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占秀安, 许梓荣
中国粮油学报,2004,19(5):75~78,-0001,():
-1年11月30日
选用480羽1日龄Avain肉鸡,随机分成4个处理组,分别饲喂添加0、25、50、75(m/kg)L-肉碱的试验饲粮49d,研究L-肉碱对肉鸡腹脂沉积的影响及其作用机理。结果表明:不同水平L-肉碱对肝重比率和肝脂含量均无明显影响(P>0.05),但添加50m/k和75m/k L-肉碱均显著地降低了肉鸡腹脂重比率(P<0.05)。添加50m/k和75m/k L-肉碱使腹脂中激素敏感脂酶的总活力增强(P<0.03),苹果酸脱氢酶的总活力降低(P<0.05);使胸肌中总肉碱含量(P<0.05)、酸不溶肉碱含量(P<0.01)及其与游离肉碱含量的比值(P<0.03)增高;使血清中总肉碱(P<0.01)、游离脂肪酸(P<0.01)和肌酸酐浓度(P<0.03)提高,甘油三酯浓度降低(P<0.05)。上述结果提示:L-肉碱通过改变鸡体内脂肪代谢相关酶的活力,促进脂肪酸的氧化利用,而产生降低腹脂沉积的效果。
L-肉碱 肉鸡 腹脂沉积 脂肪代谢
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