刘波
具有重要生物活性的天然产物全合成;合成导向的金属催化反应方法学研究。
个性化签名
- 姓名:刘波
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
有机化学
- 研究兴趣:具有重要生物活性的天然产物全合成;合成导向的金属催化反应方法学研究。
刘 波 博士 教授、博士生导师
简 历:
1994.9.---1998.7. 在西南师范大学化学化工学院学习,环境学专业;获理学学士学位
1998.9.---2001.7. 在中科院成都有机化学研究所学习,有机合成专业,主要从事不对称催化反应研究;获理学硕士学位
2001.9.---2004.7. 在中科院上海有机化学研究所学习,有机合成专业,主要从事天然产物全合成研究;获理学博士学位
2004.9.---2007.3. 在美国德克萨斯大学西南医学中心作博士后研究,主要从事过渡金属催化的反应研究及天然产物全合成。
2007.6.--- 至今 四川大学化学学院教授
主要研究方向:
具有重要生物活性的天然产物全合成;合成导向的金属催化反应方法学研究。
主要工作业绩:
曾从事不对称催化、过渡金属有机化学和天然产物全合成方面的研究。发现手性路易斯碱能够活化硅原子实现手性引入;实现了铂和金催化的对炔键的分子内选择性反应和串联反应;完成了海洋天然产物 Phorboxazoles 的片段合成及 Peloruside A 的大环骨架的合成;完成了两个海洋天然产物 Orostanal 和 Palmerolide A 的首次合成,其中,通过全合成修正了高活性天然产物 Palmerolide A 的相对和绝对构型。
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1697
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成果阅读
442
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成果数
9
【期刊论文】Studies toward the total synthesis of the hirsutellones
刘波, Mingzheng Huang, Chong Huang, Bo Liu *
Tetrahedron Letters 50(2009)2797-2800,-0001,():
-1年11月30日
A strategy of tandem ketene-trapping/IMDA toward the total synthesis of the hirsutellones was attempted. The AB ring moiety of the hirsutellones was constructed with the proper tereochemistry.
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【期刊论文】Au(I)- and Pt(II)-Catalyzed Cycloetherification of ω-Hydroxy Propargylic Esters
刘波, Jef K. De Brabander, * Bo Liu, and Mingxing Qian
ORGANIC LETTERS 2008 Vol. 10, No. 12 2533-2536,-0001,():
-1年11月30日
Depending on the nature of the metal catalyst, ω-hydroxy propargylic acetates choose between alternative cycloetherification manifolds to produce functionalized heterocycles in high yields. AuCl catalyzes the formation of oxacyclic enol acetates, whereas [Cl2Pt(CH2CH2)]2 (Zeise’s dimer) will induce a propargylic substitution via an unprecedented SN2′-type allenic substitution from within a chelated square planar cationic Pt(II) complex.
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【期刊论文】Total Synthesis and Structure Revision of the Marine Metabolite Palmerolide A
刘波, Xin Jiang, Bo Liu, Sylvain Lebreton, and Jef K. De Brabander*
J. AM. CHEM. SOC. 2007, 129, 6386-6387,-0001,():
-1年11月30日
A unique natural product termed palmerolide A was recently isolated from the antarctic marine tunicate Synoicum adareanum by Baker and co-workers.1 The structure and absolute stereochemistry of palmerolide A, expressed by formula 1 (Scheme 1), was solved by NMR studies and reveals a 20-membered macrolide decorated with a polyunsaturated N-acyl dienamine side chain distinct from the N-acyl enamine found in salicylihalamide and related natural products.2 Palmerolide is a differential cytotoxin with an activity profile that correlates to V-ATPase inhibitors.1 Subsequent in vitro studies confirmed that palmerolide A is indeed a potent inhibitor of bovine brain V-ATPase (IC50 _ 2 nM).1,3 Palmerolide was isolated from an organism found in one of the most inaccessible areas of the world, which in conjunction with commercial exploitation prohibited by the Antarctic Treaty will severely limit access to this compound from natural sources.4 Therefore, total synthesis remains as the only option to ensure investigation of palmerolide's promising antitumor properties. Herein, we present our synthetic efforts that led to the conclusion that (-)-palmerolide A is in fact a diastereomer of the proposed structure 1, that is, structure ent-24 (Scheme 4).
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刘波, Bo Liu and Jef K. De Brabander*
ORGANIC LETTERS 2006 Vol. 8, No. 21 4907-4910,-0001,():
-1年11月30日
Platinum(II) and an unusual cationic gold(I) complex were identified as mild catalysts for the room temperature cycloisomerization or tandemhydroalkoxylation/acetal formation of unactivated internal alkynols. Under the appropriate conditions, 5-endo, 5-exo, 6-endo, and 6-exo cycloisomerization modes are all available.
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刘波, Bo Liu and Wei-Shan Zhou*
ORGANIC LETTERS 2004 Vol. 6, No. 1 71-74,-0001,():
-1年11月30日
An asymmetric synthesis of the backbone of the core of natural peloruside A is described. Key elements include reiterative application ofenantioselective allylation to establish the stereochemistry of the backbone and a double asymmetric aldol reaction to successfully couple two fragments.
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【期刊论文】tereoselective synthesis of the C21 C27 fragment of the phorboxazoles
刘波, Bo Liu and Wei-Shan Zhou*
Tetrahedron Letters 44(2003)4933-4935,-0001,():
-1年11月30日
A stereoselective synthesis of the C21 C27 fragment of phorboxazoles A and B was achieved in 12 linear steps via an intramolecular cyclization induced by mercury acetate, to afford a functionalized tetrahydropyran. © 2003 Elsevier Science Ltd. All rights reserved.
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刘波
,-0001,():
-1年11月30日
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刘波, Bo Liu and Weishan Zhou*
Tetrahedron Letters 43(2002)4187-4189,-0001,():
-1年11月30日
An efficient approach to the synthesis of a sterol derivative, orostanal, has been achieved by a series of reactions from methyl hyodeoxycholanate. © 2002 Elsevier Science Ltd. All rights reserved.
stereoselective synthesis, sterol, apoptosis.,
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【期刊论文】PALMEROLIDES: METHODS OF PRER\PARATION AND DERIVATIVES THEREOF
刘波, Jef K, DE BRABANDER, Lewisville, TX (US); Xin Jiang, Dallas, TX(US); Bo Liu, Sichuan(CN)
Pantent Application Publication Oct. 9, 2008 Sheet 2 of 7,-0001,():
-1年11月30日
Organic compounds having Formulas Ⅰ and Ⅱ are provided where the variables have the values described herein. Pharmaceutical formulations include the organic compounds or pharmaceutically acceptable salts thereof and a pharma-ceutically acceptable carrrier cn be prepared, Methods of preparing the compounds includes deprotecting protected precursor compounds. Methods of treating cancer or inhibit-ing ATPase include administering the organci compunds to a subject in need thereof.
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