傅缨
主要研究方向是植物细胞形态发生过程中细胞极性生长控制机理的研究。
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- 姓名:傅缨
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学术头衔:
教育部“新世纪优秀人才支持计划”入选者, 博士生导师
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学科领域:
植物学
- 研究兴趣:主要研究方向是植物细胞形态发生过程中细胞极性生长控制机理的研究。
傅缨,博士,教授,中国农业大学植物生理学与生物化学国家重点实验室研究人员。1993年毕业于华中师范大学生物学系,获理学学士;1999年获武汉大学理学博士学位。1999-2004年在美国加州大学河滨分校植物科学系从事博士后研究,2004-2007年在该校任职Assistant Project Scientist。2007年受聘为中国农业大学生物学院植物系教授,获得中国农业大学引进特殊人才资助计划支持。2008年入选教育部“新世纪优秀人才支持计划”。 目前承担一项国家自然科学基金重大研究计划的重点项目,并参加农业部转基因生物新品种培育重大专项两项。已在Cell,Current Biology,Journal of Cell Biology,Plant Cell、Current Opinion of Plant Biology,Trends in Plant Science等国际著名杂志上发表研究论文10余篇。
研究方向:主要研究方向是植物细胞形态发生过程中细胞极性生长控制机理的研究。包括植物中重要的信号分子ROP GTPase如何通过调控细胞骨架决定植物细胞极性生长和形态发生的分子调控机制,着重研究ROP GTPase作用于细胞骨架的信号转导途径及其交互作用,并探讨ROP-细胞骨架信号转导途径调控细胞响应重要的生长发育信号―植物激素(如生长素)的机理。
承担的科研项目:获得中国农业大学引进特殊人才资助计划和教育部“新世纪优秀人才支持计划”的资助,主持国家自然科学基金重大研究专项1项,参加农业部重大专项2项。
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5
傅缨, Liming Zhou, , Ying Fu, ∗ and Zhenbiao Yang, ∗
Journal of Integrative Plant Biology 2009,-0001,():
-1年11月30日
Calcium, an ubiquitous second messenger, plays an essential and versatile role in cellular signaling. The diverse function of calcium signals is achieved by an excess of calcium sensors. Plants possess large numbers of calcium sensors, most of which have not been functionally characterized. To identify physiologically relevant calcium sensors in a specific cell type, we conducted a genome-wide functional survey in pollen tubes, for which spatiotemporal calcium signals are well-characterized and required for polarized tip growth. Pollen-specific members of calmodulin (CaM), CaM-like (CML), calcium-dependent protein kinase (CDPK) and calcineurin B-like protein (CBL) families were tagged with green fluorescence protein (GFP) and their localization patterns and overexpression phenotypes were characterized in tobacco pollen tubes. We found that several fusion proteins showed distinct overexpression phenotypes and subcellular localization patterns. CDPK24-GFP was localized to the vegetative nucleus and the generative cell/sperms. CDPK32-GFP caused severe growth depolarization. CBL2-GFP and CBL3-GFP exhibited dynamic patterns of subcellular localization, including several endomembrane compartments, the apical plasma membrane (PM), and cytoskeleton-like structures in pollen tubes. Their overexpression also inhibited pollen tube elongation and induced growth depolarization. These putative calcium sensors are excellent candidates for the calcium sensors responsible for the regulation of calcium homeostasis and calciumdependent tip growth and growth oscillation in pollen tubes.
Arabidopsis, calcium sensor, calcium signaling, Rho-related GTPase from plants, subcellular localization, tip growth
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【期刊论文】ROP/RAC GTPase signaling
傅缨, Zhenbiao Yang and Ying Fu
Current Opinion in Plant Biology 2007, 10: 490-494,-0001,():
-1年11月30日
ROP/RAC GTPases are versatile signaling molecules in plants. Recent studies of ROP/RAC regulators and effectors have generated new insights into the molecular basis of their functional versatility. Significant progress has also been made in our understanding of the mechanism for the localization of ROP/RAC signaling to specific domains of the plasma membrane.
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傅缨, Ying Fu, , Ying Gu, Zhiliang Zheng, Geoffrey Wasteneys, and Zhenbiao Yang, *
Cell, Vol. 120, 687-700, March 11, 2005, Copyright,-0001,():
-1年11月30日
Coordinating growth and communication between ad-jacent cells is a critical yet poorly understood aspect of tissue development and organ morphogenesis. We report a Rho GTPase signaling network underlying the jigsaw puzzle appearance of Arabidopsis leaf pavement cells, in which localized outgrowth in one cell is coordinated with localized inhibition of out-growth of the adjacent cell to form interdigitating lobes and indentations. Locally activated ROP2, a Rho-related GTPase from plants, activates RIC4 to promote the assembly of cortical actin microfilaments required for localized outgrowth. Meanwhile, ROP2 inactivates another target RIC1, whose activity pro-motes well-ordered cortical microtubules. RICl-depen-dent microtubule organization not only locally inhib-its outgrowth but in turn suppresses ROP2 activation in the indentation zones. Thus, outgrowth-promoting ROP2 and outgrowth-inhibiting RIC1 pathways antag-onize each other. We propose that the counteractivity of these two pathways demarcates outgrowing and indenting cortical domains, coordinating a process that gives rise to interdigitations between adjacent pavement cells.
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【期刊论文】Rop GTPase: a master switch of cell polarity development in plants
傅缨, Ying Fu and Zhenbiao Yang
TRENDS in Plant Science Vol. 6 No.12 December 2001,-0001,():
-1年11月30日
Cell polarity is fundamentally important to plant growth and development, yet the mechanism governing its development is understood poorly. Several studies have revealed a role for Rop GTPases in pollen polar tip growth. Rop is also localized to the future site of root hair development and the tip of root hairs, and expression of constitutively active Rop mutants impacts on the morphogenesis of tip-growing root hairs as well as on non-tip-growing cells. These findings highlight the importance of Rop as a common switch in cell polarity control in plants.
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傅缨, YUAN Ming, *, FU Ying, WANG Feng, HUANG Bingquan, Sze-Yong Zee & Peter K. Hepler
SCIENCE IN CHINA (Series C) April 2002 Vol. 45 No.2,-0001,():
-1年11月30日
Studies of the living embryo sacs of Torenia fournieri reveal that the actin cytoskeleton undergoes dramatic changes that correlate with nuclear migration within the central cell and the primary endosperm. Before pollination, actin filaments appear as short bundles randomly distributed in the cortex of the central cell. Two days after anthesis, they become organized into a distinct actin network. At this stage the secondary nucleus, which is located in the central region of the central cell, possesses an associated array of short actin filaments. Soon after pollination, the actin filaments become fragmented in the micropylar end and the secondary nucleus is located next to the egg apparatus. After fertilization, the primary endosperm nucleus moves away from the egg cell and actin filaments reorganize into a prominent network in the cytoplasm of the primary endosperm. Disruption of the actin cytoskeleton with latrunculin A and cytochalasin B indicates that actin is involved in the migration of the nucleus in the central cell. Our data also suggest that the dynamics of actin cytoskeleton may be responsible for the reorganization of the central cell and primary endosperm cytoplasm during fertilization.
actin,, embryo sac,, central cell,, Torenia
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