陈其才
感觉神经生物学与行为(涉及听中枢声信号的加工及调制、听觉性学习与记忆、听觉认知等)。
个性化签名
- 姓名:陈其才
- 目前身份:
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学术头衔:
博士生导师
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学科领域:
神经生物学
- 研究兴趣:感觉神经生物学与行为(涉及听中枢声信号的加工及调制、听觉性学习与记忆、听觉认知等)。
陈其才,男,生理学和神经生物学教授,享受政府特殊津贴专家。研究工作兴趣为“感觉神经生物学和行为”。所在的神经生物学实验室是学校2000年建立的重点实验室,与国内外有关同行开展经常性的学术交流,多次与美国、俄罗斯、韩国、台湾、香港等国家和地区的专家互访,建立有良好的合作关系。所做的脊椎动物心肌内分泌比较研究,成果被写入《中国生理学史》;在听觉研究方面,成果被一些国际权威学术期刊,如Nature; Nature-Neurosci;PNAS;J Neurosci; J Neurophysiol;Annu Rev Psychol;J Comp Neurol;Eur J Neurosci;Brain Res;Exp Brain Res;Cell Mol Neurobiol;J Comp Physiol A等所引用。
学会和学术兼职:中国生理学会比较生理专业委员会委员;中国科学院动物研究所“翼兽类”研究专家组副组长;中国生物医学物理研究会常务理事;湖北省生理学学会副理事长;湖北省神经科学学会常务理事;湖北省生物物理学会常务理事;国际脑研究组织(IBRO)成员;国际神经行为学会 (ISFN) 会员;美国神经科学学会 (SFN) 会员。
研究获奖:
1.“哺乳动物听中枢声信号处理及调制研究” 获“湖北省2003年自然科学二等奖”
2.1996年获美国密苏里大学“杰出研究成就奖”(Outstanding Research Achievement)
研究方向:感觉神经生物学与行为(涉及听中枢声信号的加工及调制、听觉性学习与记忆、听觉认知等)。研究工作已获得5项国家自然科学基金、3项国家教育部研究基金、1项国家外国专家局国际合作基金,以及王宽诚基金和湖北省自然科学基金的资助。
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833
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成果数
20
陈其才, N.G. Bibikov a, b, Q.C. Chen a, F.J. Wu a, *
Hearing Research 241 (2008) 43-51,-0001,():
-1年11月30日
We recorded extracellular activity from 402 single units located in the inferior colliculus (IC) of barbiturate-anesthetized albino mice. The stimuli were pure tones at characteristic frequency (CF) with durations of 10, 40 and 100 ms and intensities ranged from 5 to 25 dB above unit’s minimum threshold (MT). The tones were presented with different repetition rates (RRs) ranging from 0.2 to 20.0 Hz. At low intensities (5 dB above MT, determined at RR of 0.5 Hz) the great majority of units exhibited a strong decline of their responses when the stimulus RR was increased. About one-half of the units did not respond to 40 ms tones when they were stimulated with the RR of 3.0 Hz. This effect was even more pronounced for 100 ms tones. Generally, the increase in stimulus intensity led to an increase in the high-frequency border of RR. Nevertheless, even at intensities of 20-30 dB above MT, some units showed no response when the RR exceeded 5.0 Hz. In many cases the band-pass or high-pass duration tuning of the single unit was transformed to low-pass or all-pass when the rate was low enough to guarantee the independence of successive presentations of the stimuli. Responses of a very small group of IC units, however, were enhanced when the RR was increased. Our data have shown that the changes in the RR radically modify many features of the neural response (number of spikes, latency, discharge pattern, duration selectivity). We suggest that long-lasting inhibitory processes may be induced by low intensity stimuli in many units of the IC.
Auditory units, Duration tuning, Stimulus repetition rate, Mouse
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陈其才, Xin Wang a, Philip H.-S. Jen b, *, Fei-Jian Wu a, Qi-Cai Chen a
BRAINRESEARCH 1167 (2007) 80-91,-0001,():
-1年11月30日
In acoustic communication, animals must extract biologically relevant signals that are embedded in noisy environment. The present study examines how weak noise may affect the auditory sensitivity of neurons in the central nucleus of themouse inferior colliculus (IC)which receives convergent excitatory and inhibitory inputs from both lower and higher auditory centers. Specifically, we studied the frequency sensitivity and minimum threshold of IC neurons using a pure tone probe and a weak white noise masker under forward masking paradigm. For most IC neurons, probe-elicited response was decreased by a weak white noise that was presented at a specific gap (i.e. time window). When presented within this time window, weak noise masking sharpened the frequency tuning curve and increased the minimum threshold of IC neurons. The degree of weak noise masking of these two measurements increased with noise duration. Sharpening of the frequency tuning curve and increasing of the minimum threshold of IC neurons during weak noise masking were mostly mediated through GABAergic inhibition. In addition, sharpening of frequency tuning curve by the weak noise masker was more effective at the high than at low frequency limb. These data indicate that in the real world the ambient noise may improve frequency sensitivity of IC neurons throughGABAergic inhibitionwhile inevitably decrease the frequency response range and sensitivity of IC neurons.
Forward masking, Frequency sensitivity, Inferior colliculus, Minimum threshold, Mouse, Weak noise, Time window, Bicuculline
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【期刊论文】The Amplitude Sensitivity of Mouse Inferior Collicular Neurons in the Presence of Weak Noise
陈其才, Jia Tang, Fei-Jian Wu, Dan Wang, Philip H.-S. Jen, and Qi-Cai Chen
Chinese Journal of Physiology 50 (4): 187-198, 2007,-0001,():
-1年11月30日
Natural auditory environment consists of multiple sound sources that are embedded in ambient strong and weak noise. For effective sound communication and signal analysis, animals must somehow extract biologically relevant signals from the inevitable interference of ambient noise. The present study examined how a weak noise may affect the amplitude sensitivity of neurons in the mouse central nucleus of the inferior colliculus (IC) which receives convergent excitatory and inhibitory inputs from both lower and higher auditory centers. Specifically, we studied the amplitude sensitivity of IC neurons using a probe (best frequency pulse) and a masker (weak noise) under simultaneous masking paradigm. For most IC neurons, weak noise masking increases the minimum threshold and decreases the number of impulses. Noise masking also increased the slope and decreased the dynamic range of the rate amplitude function of these IC neurons. The strength of this noise masking was greater at low than at high sound amplitudes. This variation in the amplitude sensitivity of IC neurons in the presence of the weak noise was mostly mediated through GABAergic inhibition. These data indicate that in the real world the ambient weak noise improves amplitude sensitivity of IC neurons through GABAergic inhibition while inevitably decreases the range of overall auditory sensitivity of IC neurons.
amplitude sensitivity, bicuculline, GABA-mediated inhibition, inferior colliculus, mouse, simultaneous masking, weak noise
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陈其才, Feng Luo, , Jie Ma, An-An Li, Fei-Jian Wu, Qi-Cai Chen, and Shu-Yi Zhang, *
Zoological Studies 46 (5): 622-630 (2007),-0001,():
-1年11月30日
Echolocation calls and neurophysiological correlations with auditory response properties in the inferior colliculus of Pipistrellus abramus (Microchiroptera: Vespertilionidae). Zoological Studies 46(5): 622-630. The present study examines the echolocation calls and auditory responses of single neurons in the inferior colliculus (IC) of Pipistrellus abramus (Microchiroptera: Vespertilionidae). The data showed that there was a neurophysiological correlation of the auditory response properties with echolocation calls in IC neurons. The echolocation calls of P. abramus were broad-band swept from 86.6 to 43.2 kHz. The ending frequencies of the first harmonics which centered around 40 (average, 43.2; range, 37.0-47.0) kHz, were relatively more stable than the initial high frequencies. The average peak frequency was 52.1 (range, 43.3-57.6) kHz of which the majority (81%, 154 of 190 calls) ranged from 50.1 to 60 kHz. We recorded the responses of 75 single IC neurons to pure tones. Most IC neurons had the best frequency (BF) at between 30 and 50 kHz (centered around 40 kHz) (73%, 54 of 75) and between 50.1 and 60 kHz (19%, 14 of 75), respectively corresponding to the ending frequencies of the first harmonics and peak frequencies. The minimum threshold (MT) distribution was wider, and the average MT was significantly higher for neurons with a BF of 30-50 kHz than for neurons with a BF of 50.1-60 kHz (62±11vs. 49±8 dB SPL, p<0.001, t-test). The latency distribution was also slightly wider for neurons with a BF of 30-50 kHz (71% between 6.1 and 8.0 ms) than for neurons with a BF of 50.1-60 kHz (79% between 4.0 and 6.0 ms). Our study of echolocation calls and auditory response properties of IC neurons suggests that the IC of P. abramus can effectively process emitted pulses and echoes during hunting.
Echolocation calls, Auditory response properties, Inferior colliculus, Pipistrellus abramus
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陈其才, Qi Cai Chen, Philip H.-S. Jen*
Hearing Research 150 (2000) 161-174,-0001,():
-1年11月30日
This study examined the effect of bicuculline application on the auditory response properties in the auditory cortex of the big brown bat, Eptesicus fuscus. All auditory cortical neurons studied discharged either 1-2 or 3-7 impulses to 4 ms sound stimuli. Cortical neurons with high best frequencies tended to have high minimum thresholds. Bicuculline application increased the number of impulses and shortened the response latencies of all cortical neurons as well as changing the discharge patterns of half of the cortical neurons studied. Bicuculline application raised the rate-intensity functions but lowered the latency-intensity functions to varying degrees. Threshold-frequency tuning curves (FTCs) were either V-shaped, upper threshold or double-peaked. Threshold-FTCs and impulse-FTCs were mirror-images of each other. Bicuculline application expanded and raised the impulse-FTCs but lowered the threshold-FTCs, resulting in significantly decreased Qn values. Threshold^FTCs of cortical neurons determined within an orthogonally inserted electrode were very similar and expanded FTCs during bicuculline application were also very similar. Possible mechanisms for the contribution of GABAergic inhibition to shaping these response properties of cortical neurons are discussed.
Auditory cortex, Bat, Bicuculline, Intensity function, Frequency tuning curve
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陈其才, Philip H.-S. Jen*, Qi Cai Chen, Fei Jian Wu
Hearing Research 174 (2002) 281-289,-0001,():
-1年11月30日
Neurons in the auditory cortex (AC) receive convergent excitatory and inhibitory inputs from the lower auditory nuclei. Interaction between these two opposing inputs shapes different response properties of AC neurons. In this study, we examined how this interaction might affect the frequency tuning curves (FTCs), number of impulses and latency of AC neurons in the big brown bat, Eptesicus fuscus, using a probe (excitatory tone) and a masker (inhibitory tone) under different stimulation conditions. Excitatory FTCs of AC neurons were either V-shaped, closed (i.e. upper threshold) or double-peaked. Inhibitory FTCs were obtained either at both flanks or only at the low or high flank of excitatory FTCs. Application of bicuculline, an antagonist for Q-aminobutyric acid A receptors, produced expansion of excitatory FTCs into predrug inhibitory FTCs. Inhibition of probeelicited responses occurred when a masker was presented at certain intertone intervals. Maximal inhibition typically took place when a masker was presented within 4 ms prior to the probe. During maximal inhibition, a neuron had the minimal number of impulses and the longest response latency. Inhibition became stronger with increasing masker intensity but became weaker with increasing intertone interval. Biological significance of these data is discussed.
Auditory cortex, Bat, Bicuculline, Frequency tuning curve, Inhibition, Latency
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陈其才, Philip H.-S. Jen*, Fei Jian Wu, Qi Cai Chen
Hearing Research 168 (2002) 139-149,-0001,():
-1年11月30日
This study examined auditory responses of two simultaneously recorded neurons in the central nucleus of bat inferior colliculus (IC) under two-tone stimulation conditions. We specifically examined how a sound within the excitatory frequency tuning curve (FTC) of one IC neuron might affect responses of the other IC neuron in amplitude and frequency domains. Under this specific two-tone stimulation condition, responses of 82% neurons were suppressed and their excitatory FTCs sharpened. Responses of the other 18% neurons were facilitated and their excitatory FTCs broadened. Two-tone suppression was greater at low than at high stimulus amplitudes. Two-tone suppression also decreased with increasing recording depth and best frequency (BF) difference between each pair of neurons. The suppressive or facilitatory FTC of a neuron plotted under two-tone stimulation conditions was always within the excitatory FTC of the other neuron. Two-tone suppression or two-tone facilitation was weak near the BF but became increasingly strong with frequencies away from the BF. Biological significance of these findings is discussed.
Facilitation, Frequency tuning curve, Inferior colliculus, Suppression, Rate-amplitude function
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【期刊论文】Brief and short-term corticofugal modulation of acoustic signal processing in the bat midbrain
陈其才, Philip H.-S. Jen*, Xiaoming Zhou, Jiping Zhang, Qi Cai Chen, Xinde Sun
Hearing Research 168 (2002) 196-207,-0001,():
-1年11月30日
This article reviews our recent studies of brief and short-term corticofugal modulation of signal processing in the central nucleus of the inferior colliculus (ICc) by electrical stimulation in the primary auditory cortex (AC). When cortical electrical stimulation was synchronized with an acoustic stimulus, auditory responses of ICc neurons were either inhibited or facilitated and the modulative effect typically vanished within 5^10 s after the stimulation. When cortical electrical stimulation synchronized with an acoustic stimulus was repetitively delivered for 30 min, corticofugal modulation of collicular responses typically persisted up to 40 min after the stimulation. In the frequency domain, cortical electrical stimulation decreased the excitatory frequency tuning curves (FTCs) and asymmetrically increased the lateral inhibitory FTCs of corticofugally inhibited ICc neurons but produced the opposite effect on corticofugally facilitated ICc neurons. Cortical electrical stimulation facilitated auditory responses of neurons in the external nucleus of the inferior colliculus (ICx) while electrical stimulation in the ICx decreased auditory responses of ICc neurons. Auditory responses of simultaneously recorded ICx and ICc neurons varied in opposite ways during cortical electrical stimulation or drug application to recorded ICx neurons. In the amplitude domain, cortical electrical stimulation compressed rate amplitude functions so as to increase the slope of rate^amplitude functions of ICc neurons. This modulative effect decreased with increasing stimulus amplitude. The possible biological relevance of these findings is discussed.
Auditory cortex, Bat, Corticofugal modulation, Facilitation, Frequency tuning, Inferior colliculus, Inhibition
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【期刊论文】持续与间断噪声前掩蔽条件下小鼠下丘神经元的不同反应模式
陈其才, 李安安, 吴飞健*
Acta Physiologica Sinica, April 25, 2006, 58 (2): 141-148,-0001,():
-1年11月30日
有关听中枢神经元纯音前掩蔽效应的神经表征已进行了大量研究,但是,噪声前掩蔽尤其是间断噪声前掩蔽效应的神经表征却鲜有报道。本研究观察了自由声场条件下,昆明小鼠下丘神经元在持续与间断噪声前掩蔽条件下对纯音探测声的反应。共记录到96个下丘神经元,测量了其中51个神经元在不同声刺激条件下的强度-放电率函数。结果显示,掩蔽声强度分布较广(探测声阈下21dB至阈上19dB之间)。在将近一半的神经元中,间断噪声的前掩蔽效应比持续噪声强(Ⅰ型,45.10%,P<0.001),但也有少数神经元其间断噪声的掩蔽效应较持续噪声的弱(Ⅲ型,17.65%,P<0.001),部分神经元无显著性差异(Ⅱ型,37.25%,P>0.05)。无论Ⅰ型还是Ⅲ型神经元,持续噪声和间断噪声均在探测声强度较低时产生较强的抑制效应,随着探测声强度的升高,抑制效应逐渐降低(P<0.001); 同时,持续噪声和间断噪声之间前掩蔽效应差异亦不复存在(P>0.05)。此外,当掩蔽声由持续噪声换为间断噪声后,部分Ⅰ型神经元掩蔽时相的类型发生转变,其中最主要的转变为由前期抑制转变为均衡抑制(53.85%,7/13)。对下丘神经元声反应的时间域以及强度域,持续与间断噪声具有分化性前掩蔽效应,提示噪声前掩蔽并非简单的神经元发放压抑源,某些主动性神经调制机制可能参与了噪声条件下时相声信息的编码过程。
前掩蔽, 噪声, 下丘, 小鼠
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【期刊论文】Corticofugal control of central auditory sensitivity in the big brown bat, Eptesicus fuscus
陈其才, Xinde Sun, Qi Cai Chen, Philip H.-S. Jen*
Neuroscience Letters 212 (1996) 131-134,-0001,():
-1年11月30日
Using bats as a model auditory system, we studied corticofugal control of auditory sensitivity of neurons in the inferior colliculus. We demonstrate for the first time that the corticocollicular pathway continuously regulates acoustic signal processing in the inferior coiliculus by increasing the threshold, reducing the auditory spatial response area, and sharpening the frequency tuning curve of recorded inferior collicular neurons. Regulation of auditory sensitivity of recorded inferior collicular neurons was observed when the corticocollicular pathway was activated by electrical stimulation in the auditory cortex. The effect of this corticofugal regulation of auditory sensitivity in inferior collicular neurons can also be produced by ionophoretical application of GABA to the collicular recording site. This regulation of ascending acoustic information by commands originating from higher brain centers may provide the bat with a mechanism to actively control acoustic signal processing and thus optimize acoustic signal analysis.
Bats, Corticofugal regulation, Spatial sensitivity, Inferior colliculus
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