田大成
从事分子和基因组的进化、植物功能基因组和生物信息学的研究。
个性化签名
- 姓名:田大成
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
作物育种学与良种繁育学
- 研究兴趣:从事分子和基因组的进化、植物功能基因组和生物信息学的研究。
田大成 教授
专业方向:从事分子和基因组的进化、植物功能基因组和生物信息学的研究。
学习经历:
83-86年:四川农业大学农学硕士
93年:获南京农业大学作物遗传育种学博士
94-97年:澳大利亚Newcastle大学生物学博士
工作经历:
86-93年:四川省种子公司高级农艺师
93-94年: 四川农大水稻研究所作博士后(副教授)
97-98年:澳洲 ForBio Research Pty. Ltd.研究员
98-03年:芝加哥大学生态与进化学系博士后
主持或者参与的项目:
1、非对称基因组中特殊遗传重组规律的研究,2005-2007,国家自然科学基金(30470924), 25万(负责人)
2、水稻抗病基因组间遗传差异的产生及变异规律的研究,2006-2008,国家自然科学基金(30570987), 23万(负责人)
3、非对称重组现象的研究,2005-2007,教育部博士点基金, 6万(负责人)
获奖情况:
1、1993年:国家科技进步三等奖(杂交水稻制种高产稳产新技术研究,第一主持人)
2、1991年:四川省科技进步一等奖(杂交水稻制种高产稳产新技术研究,第一主持人)
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成果阅读
63
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成果数
1
【期刊论文】A molecular isolation mechanism associated with high intra-specific diversity in rice
田大成, Sihai Yang a, Ke Jiang a, Hitoshi Araki b, Jing Ding a, Yong-Hua Yang a, *, Dacheng Tian a
Gene 394(2007)87-95,-0001,():
-1年11月30日
High levels of inter-specific diversity are expected due to genetic isolation, the reproductive or geographical barriers, which lead to the accumulation of nucleotide variation. However, high levels of genetic variation are repeatedly observed even within species, notably at loci of the human major histocompatability complex and of plant resistance genes. Are molecular isolations responsible for the high intra-specific variation? To address this issue, we performed a genome-wide survey of the relationship between the possible factors that could cause genetic isolation, and the level of polymorphism, based on two rice genome comparisons. Here, we show that the levels of polymorphism in rice genes are positively correlated with the proportions of non-alignable flanking sequences, and that the correlation is observed even in single-copy genes. The physical locations of the genes were also investigated, and a strong association between the asymmetric architecture of genomes and the levels of polymorphism was revealed. These results suggest that the flank heterogeneity and the asymmetric architecture between genomes serve as isolation mechanisms at the molecular level that result in accumulation of higher genetic variation. This mechanism is of fundamental importance to understand natural genetic variation within species.
Genetic isolation, Intraspecific diversity, Flank heterogeneity, Asymmetric architecture
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