桑楠
博士研究生 教授
山西大学 环境与资源学院
主要从事环境科学专业环境毒理学方向的科研和教学工作。
个性化签名
- 姓名:桑楠
- 目前身份:在职研究人员
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:高级-教授
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学科领域:
环境科学技术基础学科
- 研究兴趣:主要从事环境科学专业环境毒理学方向的科研和教学工作。
桑楠,山西大学环境与资源学院教授、博士生导师。
1995年毕业于山西大学环境科学系,获学士学位,同年免试推荐成为山西大学环境科学专业首届硕士研究生;1998年7月毕业于山西大学环境科学专业,获硕士学位,同年留校任教;1999年9月在职攻读山西大学环境科学专业博士研究生,2002年7月获博士学位;2004年7月-2006年8月在美国路易斯安那州立大学健康科学中心(Louisiana University Health Science Center,LSUHSC)进行博士后研究。
主要从事环境污染与健康方面的研究工作。主持国家和省部级科研项目10余项,包括国家优秀青年科学基金项目、国家自然科学基金面上项目和教育部博士点基金(博导类)项目等。以第一作者或通讯作者在Environmental Health Perspectives、Environmental Science & Technology、Particle and Fibre Toxicology、Scientific Reports、Toxicological Science、Chemical Research in Toxicology等期刊上发表SCI收录论文50余篇。研究成果被Chemical Reviews、Physiological Reviews、Nature Reviews Neuroscience等学术期刊论文引用,累计他引700余次,并多次在国内外学术会议上交流。2012年获得首届国家优秀青年科学基金资助,同时入选山西省高等学校中青年拔尖创新人才支持计划;2010年入选教育部新世纪优秀人才支持计划;2008年获得教育部霍英东青年教师奖,入选山西省高等学校优秀青年学术带头人支持计划。
兼任SCI期刊Sci Total Environ编委(Editorial Board)、中文核心期刊《环境化学》编委。
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桑楠, 韩明, 桑楠*
,-0001,():
-1年11月30日
焦化废水是煤高温干馏、煤气净化、副产品回收与精制过程中产生的难降解工业有机废水,其中含有大量的氨、氰、硫氰根、氟化物等无机污染物,同时还含有酚、油、胺、萘、吡啶、喹啉、葸等杂环及多环芳香族化合物(PAHs),组分复杂、污染物浓度高。这一水质特征决定了焦化废水的生物处理效果有限,理化处理成本高。在此基础上,有研究者提出利用植物-土壤系统进行修复,但其关键在于植物能否耐受焦化废水造成的环境胁迫。为此,本文以北方常见植物玉米为实验材料,探讨焦化废水对其生长和抗氧化系统的影响,旨在阐明焦化废水污染土壤植物修复的可行性。结果表明,一定浓度焦化废水可降低根尖细胞有丝分裂指数,影响植株生长;诱导超氧化物歧化酶(SOD)、过氧化物酶(POD)、过氧化氢酶(CAT)和抗坏血酸过氧化物酶(APX)活性增加,提高了抗坏血酸(AsA)和谷胱甘肽(GSH)含量;高浓度则可造成脂质过氧化和蛋白质氧化的损伤。结果提示,焦化废水胁迫可引起植物生长和体内抗氧化系统的变化,但此作用存在浓度和时间依赖性关系,为探讨焦化废水污染的植物修复提供了实验依据。
焦化废水, 玉米, 抗氧化系统, 植物修复
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桑楠, 李宏艳, 桑楠*
,-0001,():
-1年11月30日
生活垃圾填埋场渗滤液是指在垃圾堆放和填埋过程中由于发酵和雨水淋溶、冲刷以及地表水和地下水的浸泡而渗滤出来的污水,其中不仅含有大量的有机物、氨氮和重金属,同时含有多种微生物、致病菌和病毒等,是一种营养物质与有毒物质共存的高浓度难降解有机废水。渗滤液的形成和渗漏可造成填埋场周边地区地表水和地下水的严重污染,甚至危害公共健康。为此,本文研究了渗滤液对高等植物(玉米和大麦)和哺乳动物(昆明种小鼠)的毒性作用。结果表明,渗滤液对玉米和大麦种子萌发、幼苗生长和细胞有丝分裂均具有低浓度促进和高浓度抑制的效应,并可浓度和时间依赖性地诱导植物幼苗根尖细胞中微核、核固缩和核碎解、染色体后期异常、姐妹染色单体交换等遗传物质损伤的发生。哺乳动物实验结果表明,渗滤液可引起小鼠骨髓微核嗜多染红细胞中微核率浓度依赖 性地增加,改变不同组织器官(心、脑、肝、肺和肾)抗氧化酶活性,诱导脂质过氧化和蛋白氧化的发生。上述结果提示,生物毒性检测指标应纳入对渗滤液污染的控制和评价体系中。
渗滤液, 植物和动物毒性, 骨髓微核嗜多染红细胞微核, 氧化损伤
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【期刊论文】SO2 吸入对大鼠海马组织炎性因子水平,钙稳态和即早基因,凋亡基因表达的影响
桑楠, 云洋, 侯丽, 桑楠*
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-1年11月30日
SO2 是一种常见的全球性大气环境污染物,前期研究提示其不仅能引起呼吸道疾患,极有可能还与一些中枢神经系统疾病的发生有关,但后者的分子机制尚不清楚。为此,本文采用动式熏气法研究了不同浓度SO2(7、14、28 和56mg/m3)吸入对大鼠海马组织炎性因子白介素-1β(IL-1β)和肿瘤坏死因子(TNF-α)水平、神经元胞内游离Ca2+浓度,即早基因(c-fos,c-jun 和COX-2)和凋亡相关基因(bcl-2,bax 和p53)表达的影响。结果表明:SO2 可造成海马组织IL-1β 和TNF-α水平显著增高,但低浓度下(7、14mg/m3)作用较为明显;SO2 可显著增加神经 元胞内钙离子浓度,上调即早基因c-fos,c-jun 和COX-2,凋亡基因bcl-2,bax和p53 mRNA 及其蛋白表达,且呈现出明显的剂量-效应关系,其中对COX-2 基因表达的作用最为明显。这一结果从整体水平上说明了SO2 对中枢神经系统的损伤效应,并提示其分子机制可能涉及炎性反应、钙离子稳态、即早基因和凋亡基 因表达。
SO2 海马神经元, 炎性因子, 胞内Ca2+, 浓度, 即早基因 凋亡相关基因
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【期刊论文】SO2 inhalation inducesproteinoxidation,DNA-proteincrosslinksand apoptosisinrathippocampus
桑楠, NanSang*, LiHou, YangYun, GuangkeLi
Ecotoxicology and Environmental Safety 72(2009)879-884,-0001,():
-1年11月30日
Previous studiesprovideevidenceforthepossibleneurotoxicityof SO2, butlittleinformationis availableaboutitsmechanisms. Inthepresentstudy, SO2 inhalation-inducedeffectsontheprotein oxidation, DNA-proteincrosslinksandapoptosisinrathippocampuswerestudied, byexposingWistar rats to SO2 at 14, 28and56mg/m3. Theresultsindicatethattheproteincarbonylcontent, anindicatorof proteinoxidation, andDNA–proteincrosslinkcoefficientweresignificantlyaugmented with concentration-dependentproperties. Inaddition, SO2 inhalationatallconcentrationstestedcaused the increasesofcaspase-3activityandnumberofTUNELpositivestainingneuronandthestatistical difference asobservedafter28and56mg/m3 exposure, suggestingtheoccurrenceofapoptosis. The results implythatattackingprotein, nucleicacidsandlipidsbyfreeradicals, generatedvia SO2 derivatives in vivo, isoneofthemainmechanismsfor SO2-inducedinjuriesincentralneuronalsystem
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桑楠, Hongyan Li, Ming Han, Li Hou, Guangke Li, Nan Sang∗
Journal of Hazardous Materials 174(2010)54-58,-0001,():
-1年11月30日
In the present study, protein oxidation (PCO content) and DNA-protein crosslinks (DPC coefficient) were investigated in the viscera of mice exposed to a municipal landfill leachate at various concentrations for 7 days. The study was designed to investigate the injuries and a possible mechanism of landfill leachateinduced toxicity on mammals. The results indicate that the leachate sample changed the ratio of viscera to body weight in all organs tested, and the effect on the brain was more obvious than that on other organs. The leachate ingestion increased PCO levels in the brain, kidney, liver and spleen in a concentrationdependent manner, but did not affect the content in the heart. Also, the leachate sample enhanced DPC formation in the tested organs in a concentration-dependent manner, and the responses of the liver, kidney and spleen were more sensitive than that of the brain and heart. These findings provide further evidence that landfill leachate-induced toxicity on mammals might involve the formation of free radicals, either via autoxidation or by enzyme-catalyzed oxidation of pollutants in leachate, and then attack of proteins and nucleic acids via generated free radicals.
Landfill leachate Protein oxidation DNA-protein crosslinks Mouse viscera
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桑楠, Guangke Li, Yang Yun, Hongyan Li, Nan Sang*
Journal of Hazardous Materials 155(2008)10-16,-0001,():
-1年11月30日
With increasing use of municipal solid waste landfills for waste disposal, the leachate generated has become a serious environmental concern. Therefore, it is important to set up simple and accurate methods for monitoring leachate toxicity. In the present study, the physiological and genetic toxicity of the leachate, generated from Xingou Municipal Landfill in China, were investigated with Triticum aestivum (wheat) bioassay. The results indicate that the lower leachate concentrations stimulated the germination, growth and cell division, and did not induce obvious increase in micronucleus (MN) frequency in root tips; while the higher concentrations inhibited the processes, and significantly augmented the MN frequency in a concentration-and time-dependent manner. In addition, pycnotic cells (PNC) and sister chromatid exchange (SCE) occurred in root tips at all leachate concentrations tested, and the frequencies had positive relation with the treatment concentration and time. The results imply that components of leachate from the landfill may be genotoxic in plant cells, and exposure to leachate in the aquatic environment may pose a potential genotoxic risk to organisms. The results also suggest that the wheat bioassay is efficient, simple and reproducible in monitoring genotoxicity of the leachate.
Municipal landfill leachate, Triticum aestivum, Mitotic index (, MI), , Micronucleus (, MN), , Sister chromatid exchange (, SCE),
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【期刊论文】硫酸镁调节SO2衍生物对大鼠海马神经元钠通道的刺激作用*
桑楠, 桑楠**, 云洋, 李广科, 孟紫强, CHEN Chu
应用与环境生物学报,2008,14(1):074~077,-0001,():
-1年11月30日
利用全细胞膜片钳技术研究了硫酸镁(Mgs04)对s02衍生物刺激大鼠海马神经元电压门控性钠通道的调节作用。结果表明,Mgs04 对SO2 衍生物增大大鼠海马神经元钠电流的效应具有抑制作用,此作用随着SO2 衍生物浓度的增加而减弱,随着Mgs04 浓度的增加而增强。不同时间加入MgsO4 均会显著抑制SO2衍生物增大钠电流的效应,说明Mgs04不仅对SO2衍生物增大钠电流的效应具有抑制作用,而凡可即时和延效性地抑制此损伤效应的发生。研究结果提示,硫酸镁对SO2 衍生物刺激大鼠海马神经元钠通道具有抑制作用,这可能是MgS04 对SO2 引发的中枢神经系统损伤具有防护和治疗作用的机制之一。图4参14
海马神经元, 全细胞膜片钳技术, Mgs04, s02 衍生物, 电压门控性钠通道
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桑楠, Guangke Li, NanSang*
Ecotoxicology and Environmental Safety 72(2009)236-241,-0001,():
-1年11月30日
Recent studies implicate the possible neurotoxicity of SO2, wever, its mechanisms remain unclear. In the present study, we investigated SO2 derivative-induced effect on delayed rectifier potassium channels(IK) and cellular death/apoptosis in primary cultured hippocampal neurons. The results demonstrate that SO2 derivatives (NaHSO3 and Na2SO3, 3:1M/M) effectively augmented IK and promoted the activation of delayed rectifier potassium channels. Also, SO2 derivatives increased neuronal death percentage and contributed to the formation of DNA ladder in concentration-dependent manners. Interestingly, the neuronal death and DNA ladder formation, caused by SO2 derivatives, could be attenuated by the delayed rectifier potassium channel blocker (tetraethylammonium, TEA), but not byt het ransient outward potassium channel blocker(4-aminopyridine, 4-P). It implies that stimulating delayed rectifier potassium channels were involved in SO2 derivative-caused hippocampal neuronal insults, and blocking these channels might be one of the possibly clinical treatment for SO2-caused neuronal dysfunction.
Hippocampalneurons, Sulfurdioxide(, SO2), derivatives, Neuronaldeath/, apoptosis, Delayedrectifierpotassiumcurrent(, IK),
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【期刊论文】Assessing the phytotoxicity of different particle-size aged refuse using Zea mays L. bioassay
桑楠, Guangke Li, Jing Niu, Nan Sang*
Chemosphere 74(2008)106-111,-0001,():
-1年11月30日
With increasing attention paid to the recycling use of aged refuse as vegetated soil, it is important to check its possible polluting risk and probe the tolerance of plant system to its stress. For this reason, several physiological responses in Zea mays[Gren Open L. Close][Red_L.Red Close] (maize) to the leaching samples of aged refuse in different particlesize [Gren Open (90-30, 30-150, 150-105, 105-90, Gren Close][Red Open(900-300, 300-150, 150-105, 105-90,and 90-0μm Red Close]and [Gren Open 900 Close][Red Open90-oRed Close] lm) were investigated in the present study, including growth, lipid peroxidation, protein oxidation and activities of antioxidant enzymes. The results indicate that the aged refuse affected the growth of maize seedlings, and elevated the levels of lipid peroxidation and protein oxidation in leaf tissues in a time-dependent manner, accompanying by the changes of antioxidant status. Also, above physiological responses varied as a function of particle-size distribution of the aged refuse, and statistical growth inhibition and oxidative stress occurred after the exposure of smaller particle-size samples, which contained higher level trace metals, the characteristic pollutants in the aged refuse. The results implicate that aged refuse might cause environmental stress on plant system, but the polluting risk mainly resulted from smaller particle-size samples. Therefore, the critical point of utilizing aged refuse as vegetated soil focused on analyzing its particle-size distribution, and screening out appropriate particle- size samples.
Aged refuse Particle-size distribution Zea mays L., Oxidative stress Antioxidant enzymes
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桑楠, 李广科, 牛静, 云洋, 王爱英, 席玉英
农业环境科学学报,2008,27(1):0333~0337,-0001,():
-1年11月30日
分析了太原市新沟垃圾填埋场渗滤液的水质特征,并以COD+作为主要指标探讨了垃圾中有机成分,含水率,以及c、H、O、N等元素含量对渗滤液水质的影响。在此基础上,利用植物检测系统考察了渗滤液对种子萌发和幼苗生长的毒性效应。结果表明。太原市新沟垃圾填埋场渗滤液有机污染物浓度高、水质随季节变化较大,垃圾中有机成分、含水率以及c、H、0、N等元素含量影响渗滤液水质,可能改变其污染特性。高浓度渗滤液可抑制植物萌发和幼苗的正常生长,且表现出对染毒浓度和处理时间的双重依赖性;但低浓度渗滤液对植物萌发和幼苗生长过程没有显著影响,甚至在一定浓度条件下可促进植物的生长发育。
垃圾渗滤液, 垃圾成分, 植物检测系统
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