柴新禹
1.生物医学信号检测及处理;2.视觉功能修复与视觉假体;3.听觉无创诊断与耳声发射;4.智能化生物医学仪器。
个性化签名
- 姓名:柴新禹
- 目前身份:
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学术头衔:
博士生导师
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学科领域:
光学
- 研究兴趣:1.生物医学信号检测及处理;2.视觉功能修复与视觉假体;3.听觉无创诊断与耳声发射;4.智能化生物医学仪器。
柴新禹,上海交通大学教授,博士生导师。1963年12月生。1998年12月于西安交通大学获得博士学位,1999年4月至2001年4月在上海交通大学从事博士后工作,2001年4月至今在上海交通大学生命科学技术学院生物医学工程系工作。作为项目负责人先后承担了多项国家纵向和企业横向研究课题,包括国家973计划子课题、国家科技支撑计划世博科技专项、国家863计划、国家自然科学基金、中国博士后科学基金、国防预研项目等,作为主要成员还参与了高等学校学科创新引智计划(111计划)、上海市科技攻关计划等。在国内外学术刊物及国际会议上发表论文近100篇,SCI/EI收录40余篇,申请国家发明专利10余项(授权5项)。荣获省部级科技奖2项,国际ARVO、SPIE会员,Artificial Organs审稿人,Interdisciplinary Sciences编委,参与撰写国际学术专著2部。
主要研究方向:
1.生物医学信号检测及处理
2.视觉功能修复与视觉假体
3.听觉无创诊断与耳声发射
4.智能化生物医学仪器
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【期刊论文】Laser Induced Collagen Remodeling: A Comparative Study In Vivo on Mouse Model
柴新禹, Huaxu Liu, MD, PhD, , Yongyan Dang, Zhan Wang, Xinyu Chai, and Qiushi Ren, PhD*
Lasers in Surgery and Medicine 40: 13-19(2008),-0001,():
-1年11月30日
Materials and Methods: The dorsal skin ofKMmice was exposed by depilation before the laser treatments. Four laser treatment modalities were used: the 595-nm pulsed dye laser (PDL) (10 ms), 1,320-nm neodymium–yttrium-aluminum garnet (Nd:YAG) laser (0.35 ms), 1,064-nm Nd:YAG laser with Q-switched (5 ns), and long-pulsed (0.3 ms) mode. Each modality exposed one side of the mouse dorsal skin leaving the other side as the contralateral control. Then skin histology, fibroblast number, and the genesis of collagen type I and III were studied by comparing the treatment site and control site at 1 hour, 1 day, 1 week, 3 weeks, 4 weeks, and 8 weeks after laser treatment. Hydroxyproline content of the skin tissue was measured 4 weeks and 8 weeks after laser exposure. Results: All laser treatments led to marked improvements in dermal layer thickness and collagen fiber density, and the increase in fibroblast number and hydroxyproline content compared with their own controls. Collagen synthesis and remodeling induced by the Q-switched 1,064-nm laser was most effective 4 weeks after treatment, while there was no significant difference among the other three modalities. Among the new collagen genesis after the different laser treatments, collagen type III increased sharply after the Q-switched 1,064-nm laser treatment whereas more collagen type I was elicited by the other laser treatment modalities. Conclusions: The efficacy of photo-mechanical effects in promoting more effectively the synthesis of collagen type III, whereas the photo-thermal effect favored more the formation of collagen type I. Lasers Surg. Med. 40: 13-19, 2008.
collagen remodeling, laser, mouse model
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