陈景东
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- 姓名:陈景东
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学科领域:
微电子学
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陈景东,博士,讲师,2013年毕业于上海交通大学,获微电子学与固体电子学博士学位,同年进入太原理工大学“新型传感器和智能控制教育部和山西省重点实验室”。主要研究方向为微型能源,应用于生物检测方面微流控芯片等MEMS器件。已在Biomicrofluidics, Appl. Phys. Lett., Nano-Micro Lett., Sensors and Actuators A: Physical, Microsyst. Technol.等高水平SCI期刊上发表论文10余篇,申请发明专利6项,已获授权4项。2010年2月赴德国开姆尼茨工业大学进行 “先进互连和微纳系统材料及其概念研究”项目研究工作。先后参与参与了包括国家973、863、国家自然基金、国际合作项目及医工(理)交叉基金等项目研究。曾担任Biomicrofluidics, Micro & Nano Letters等国际SCI期刊审稿人。
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522
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成果数
10
【期刊论文】Microfluidic chips for cells capture using 3-D hydrodynamic structure array
陈景东, Jingdong Chen, Di Chen, Tao Yuan, Xiang Chen, Jun Zhu, Andreas Morschhauser, Joerg Nestler, Thomas Otto and Thomas Gessner
Microsyst. Technol. 2014, 20 (3): 485-491.,-0001,():
-1年11月30日
Microfluidic chips were designed and fabricated to capture cells in a relative small volume to generate the desired concentration needed for analysis. The microfluidic chips comprise 3D cell capture structures array fabricated in PDMS. The capture structure includes two layers. The first layer consists of spacers to create small gap between the upper layer and glass. The second layer is a sharp corner U-shaped compartment with sharp corners at the fore-end. And another type capture structure with Y-shaped fluidic guide has been designed. It was demonstrated that the structures can capture cells in theory, using Darcy-Weisbach equation and COMSOL Multiphysics. Then yeast cell was chosen to test the performance of the chips. The chip without fluid guides captured approximately 1.44×105 cells and the capture efficiency was up to 71%. And the chip with fluid guides captured approximately 5.0×104 cells and the capture efficiency was approximately 25%. The chip without fluid guides can capture more cells because the yeast cells in the chip without fluid guides are subject to larger hydrodynamic drag force.
Microfluidic chip, cells capture, hydrodynamic structure, 3-D
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【期刊论文】A novel MEMS elastic-based dry electrode for electroencephalography measurement
陈景东, Tao Yuan, Di Chen, Jingdong Chen, Xiang Chen, Xiaowei Wang and Baoliang Lu
Microsyst. Technol. 2014, 20 (6): 1125-1129.,-0001,():
-1年11月30日
Electroencephalogram (EEG) has been one of the important means to study brain functions and diseases.We fabricated an innovative MEMS elastic-based dry electrode using photolithography and electroforming process.The pitch of elastic-based dry electrode tip is 100 lm.We adopted polydimethylsiloxane as an elastic layer which provides the flexibility when the conductive layer and the electrode tip contact with the skin. This kind of dry electrode array does not need conductive gel during testing procedure. Compared with the traditional Ag/AgCl wet electrode, it greatly reduced the preparation time for EEG measurement and it could make the examinee more comfortable.
MEMS, elastic-based, dry electrode, electroencephalography
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【期刊论文】The design and fabrication of a low-field NMR probe based on a multilayer planar microcoil
陈景东, Weiping Wu, Hong Yi, Di Chen, Rongsheng Lu, Tao Yuan, Jingdong Chen and Zhonghua Ni
Microsyst. Technol. 2014, 20 (3): 419-425.,-0001,():
-1年11月30日
The nuclear magnetic resonance (NMR) probe has great influence on signal transmission and reception in NMR technology applications. In this paper, we present a design, fabrication, and test of an NMR probe comprised of a multilayer planar microcoil with a polydimethylsiloxane (PDMS) microchannel. First, geometric parameters of the probe are determined through theoretical analysis. Second,based on a glass substrate, the multilayer planar microcoil is manufactured using repeated photolithography and electroplating processes. During the fabrication process,the polyimide layer is used to package the coil, and the PDMS interlayer is used to adjust the distance from centerlines between the coil and the sample chamber. Third,the resistance and the quality factor of the coil are found to be 1.2158 X and 7.217, respectively, at a Larmor frequency of 28.1 MHz. Finally, the NMR probe is tested in an NMR experiment. The transverse relaxation time T2 for the solid PDMS is 20.6 ± 0.4 ms, which is in agreement with 21.1 ± 0.2 ms obtained by a Bruker Minispec MQ60.Results show that the design and fabrication of this NMR probe are feasible for time-domain NMR applications.
low-field NMR probe, multilayer planar microcoil, polydimethylsiloxane
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【期刊论文】Design, fabrication and characterization of MEMS probe card for fine pitch IC testing
陈景东, Tao Yuan, Di Chen, Jingdong Chen, Hualin Fu, Steffen Kurth, Thomas Otto and Thomas Gessner
Sensors and Actuators A: Physical. 2013, 204: 67-73.,-0001,():
-1年11月30日
tThis article introduces a novel type of MEMS probe card that uses polymer (polydimethylsiloxane, PDMS)as an elastic layer. The elastic layer provides the flexibility when the probes are in contact with the chippads. Through-holes in the PDMS and the low temperature co-fired ceramic (LTCC) substrate lead thesignals or power to the back side of the LTCC substrate. The proposed MEMS probe card configurationpotentially improves the probe density and simplifies the fabrication process. The probes are formedby electroplating on the PDMS substrate. The PDMS elastic substrate probe card with a probe pitch of100 m was developed for area array pad testing. The contact force is approximately 18 mN when theprobes overdrive is 20 m. Coplanar waveguides structures can be fabricated on the PDMS surface. Themeasured insertion loss is 0.2 dB at 3 GHz.The test data exhibited that the PDMS elastic substrate probecard is suitable for high-frequency wafer level IC testing.
Probe card, Polydimethylsiloxane, Elastic substrate, IC testing
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【期刊论文】A microfluidic chip for direct and rapid trapping of white blood cells from whole blood
陈景东, Jingdong Chen, Di Chen, Tao Yuan, Yao Xie and Xiang Chen.
Biomicrofluidics 2013, 7(3): 034106.,-0001,():
-1年11月30日
Blood analysis plays a major role in medical and science applications and white blood cells (WBCs) are most often the target of analysis. We proposed an integrated microfluidic chip for rapid trapping WBCs from whole blood directly. The microfluidic chip consists of two basic functional units: a winding channel to mix and arrays of two-layer trapping structures to trap WBCs. Red blood cells (RBCs) were eliminated through moving the winding channel and then WBCs were trapped using the arrays of trapping structures. The microfluidic chip was fabricated in the biologically compatible PDMS (polydimethylsiloxane) using MEMS (microelectromechanical system) fabrication technology. We determined the critical flow velocities of tartrazine water and brilliant blue water mixing and whole blood and red blood cell lysis buffer mixing in the winding channel. They are 0.25 μl/min and 0.05 μl/min, respectively. The critical flow velocity of the whole blood and red blood cell lysis buffer is lower due to larger volume of the RBCs and higher kinematic viscosity of the whole blood. Under this flow velocity, the RBCs were lysed completely by mixing and the WBCs were trapped by the trapping structures.
white blood cell, whole blood, microfluidic chip
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【期刊论文】Progress of microfluidics for biology and medicine
陈景东, Jingdong Chen, Di Chen, Yao Xie, Tao Yuan and Xiang Chen.
Nano-Micro Lett. 2013, 5(1): 66-80.,-0001,():
-1年11月30日
Microfluidics has been considered as a potential technology to miniaturize the conventional equipments and technologies. It offers advantages in terms of small volume, low cost, short reaction time and high-throughput. The applications in biology and medicine research and related areas are almost the most extensive and profound. With the appropriate scale that matches the scales of cells, microfluidics is well positioned to contribute significantly to cell biology. Cell culture, fusion and apoptosis were successfully performed in microfluidics. Microfluidics provides unique opportunities for rare circulating tumour cells isolation and detection from the blood of patients, which furthers the discovery of cancer stem cell biomarkers and expands the understanding of the biology of metastasis. Nucleic acid amplification in microfluidics has extended to single-molecule, high-throughput and integration treatment in one chip. DNA computer which is based on the computational model of DNA biochemical reaction will become practice from concept in the future. In addition, microfluidics offers a versatile platform for protein-protein interactions, protein crystallization and high-throughput screening. Although microfluidics is still in its infancy, its great potential has already been demonstrated and will provide novel solutions to the high-throughput applications.
Microfluidics, Lab-on-a-chip, Droplet, High-throughput, Cell, Nucleic acid amplification, Protein engineering, Screening
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【期刊论文】A multi-frequency sandwich type electromagnetic vibration energy harvester
陈景东, Jingdong Chen, Di Chen, Tao Yuan and Xiang Chen
Appl. Phys. Lett. 2012, 100 (21): 213509,-0001,():
-1年11月30日
We proposed a multi-frequency sandwich type vibration energy harvester to widen the effective frequency range of vibration energy harvester. The harvester is composed of three resonant structures with different natural frequencies. The resonant structures are two cantilevers each with bi-layer coils and a plane spring with a magnet. The maximum peak-peak voltages of the three different frequencies are 172 mV, 104 mV and 112 mV at the frequencies of 235 Hz, 330 Hz and 430 Hz, respectively. The first maximum voltage is much higher than the others, because the coils in both cantilevers can produce voltages.
multi-frequency,, electromagnetic,, energy harvester,, sandwich type
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【期刊论文】Separation of circulating cancer cells by unique microfluidic chip in colorectal cancer
陈景东, Hangxiang Du, Zhigang Wang, Zhili Yang, Di Chen, Jingdong Chen and Ruijun Hu
Oncology Research, 2012, 19(10-11): 487-500,-0001,():
-1年11月30日
Circulating tumor cells (CTCs) from peripheral blood are emerging as a useful tool for the detection of malignancy, monitoring disease progression, and measuring response to therapy. We describe a unique microfluidic chip that was capable of efficient and selective separation of CTCs from peripheral whole blood samples. The ability of microfluidic chip to capture CTCs from PBS and whole blood samples was tested.Sixty-eight peripheral blood samples from 68 colorectal cancer patients were investigated for the presence of CTCs by microchip technology. The frequency of CTCs was analyzed statistically for correlation with relevant clinical data. We also examined samples from 20 healthy individuals as controls. The calculated capture efficiency was 85.7% and decreased significantly at flow rates above 2.0 ml/h. The number of CTCs isolated ranged from 3 to 236/ml for colorectal patients [99 ± 64 (mean ± SD) CTCs/ml]. None of the 20 healthy subjects had any identifiable CTCs. We identified CTCs in 46 (67.65%) of the 68 patients: in two of nine (22.22%) Dukes A, in 10 of 24 (41.67%) Dukes B, in 21 of 22 (95.45%) Dukes C, and in all 13 Dukes D patients. The detection rate in Dukes C and D patients was much higher than in Dukes A and B patients (97.73% vs. 36.36%) (p < 0.01). A significant correlation between detection of CTCs and clinical stage (r = 0.792, p < 0.01) was found, which was higher than carcinoembryonic antigen (r = 0.285, p > 0.01), carbohydrate antigen 19-9 (r = 0.258, p > 0.01), α-fetoprotein (r = 0.096, p > 0.01), and cancer antigen 125 (r = 0.134, p > 0.01). Microfluidic chip provides a novel method for capturing CTCs. The presence of CTCs correlated with clinical stage. It is important to evaluate CK-positive and DAPI-stained tumor cells together to determine the role of CTCs in tumor behavior and disease progression.
Circulating tumor cells, Colorectal neoplasms, Microfluidic analytical techniques, Neoplasm metastasis
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陈景东, 胡锐军, 陈迪, 陈翔, 吴澄, 杜航向, 杨治力, 王志刚, 夏骏
功能材料与器件学报, 2011, 17(2): 227-232.,-0001,():
-1年11月30日
癌症是影响人类健康的重大疾病之一, 如何快速、方便地分离癌细胞已经成为制约临床医学和科学研究的重要问题。本文将磁珠技术与MEMS技术相结合, 提出了一种等边三角排列的N i微磁柱结构, 在磁场作用下使用CD326免疫磁珠捕获结肠癌细胞。本文对MEMS细胞捕获芯片进行了设计、加工和封装, 采用该芯片对与磁珠结合的结肠癌细胞进行了捕获, 0. 1m l/h流速下捕获效率达92%,证明该芯片具有对结肠癌细胞的捕获能力。
结肠癌细胞捕获, 免疫磁珠
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陈景东, 吴澄, 陈迪, 胡锐军, 陈翔, 王晓韡, 吕宝粮
上海交通大学学报, 2011, 45(07): 1035-1040.,-0001,():
-1年11月30日
设计了一种新型的脑电图干电极, 主要用于采集脑电信号以进行基于脑电图的警觉度分析, 替代传统的湿电极. 采用柔性衬底微电子机械系统( MEMS) 加工技术, 在柔性衬底上制备出具有化学稳定性与生物相容性的微针状干电极阵列. 通过铜牺牲层实现干电极微针的悬臂梁结构, 利用聚二甲基硅氧烷( PDMS) 剥离层实现器件从玻璃基底的完全释放, 并经平面电极的多层组装实现了立体电极阵列. 实验中干电极以聚酰亚胺作为柔性衬底, 其针端及导线部分材料为镍, 针端部分表面镀金. 采用Neuroscan 的脑电信号采集放大器对干电极性能进行了测试, 测得阻抗约为10k 8, 其时域和频域信号与传统湿电极基本一致. 所制备的干电极成品率高、尺寸小、屏蔽佳、装配简单、可靠性好、机械强度大, 符合快速、无痛的脑电信号采集要求。
干电极阵列, 柔性衬底, 微电子机械系统技术, 多层组装, 脑电图
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