刘立建
生物医用高分子化学,生物降解高分子,微波聚合反应,不对称合成及反应
个性化签名
- 姓名:刘立建
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学术头衔:
博士生导师
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学科领域:
勘查地质学
- 研究兴趣:生物医用高分子化学,生物降解高分子,微波聚合反应,不对称合成及反应
1988年获博士学位武汉大学化学与分子科学学院教授,博导生物医用高分子材料教育部重点实验室主任。湖北省化学化工学会高分子化学专业委员会主任委员,中国微波化学专业委员会委员主要研究领域: 生物医用高分子化学,生物降解高分子,微波聚合反应,不对称合成及反应
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505
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10
刘立建, YING SONG, LIJIAN LIU*, XIAOCHENG WENG and RENXI ZHUO
J. Biomater. Sct. Polymer Edn, Vol. 14, No.3, pp. 241-253 (2003) ,-0001,():
-1年11月30日
Acid-initiated ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) was con-ducted under microwave imadiation (MI) at 2.45 GHz. At this frequency, metallic catalysts were no longer necessary, The effects of microwave power, imadiation time, ε-CL: acid molar ratio and acidity of acid on the polymerization were investigate. Both the rate of polymerization and the mollar mass of polymer obtained were enhanced in comparison with conventiona thermal method. Poly (ε-caprolactone) (PCL) with weight-average molar mass (Mw) over 12000g/mol and Mw/Mn below 1.6 was synthesized in the presence o carboxylic acids such as maleic acid (MA), succinic acid (SA) and adipic acid (AA). The polymerization was also carried out when the monoiner contained a certain amount of ibuprofen (IBU), by which, the IBU-PCL controlled release systern was prepared directly. The release of IBU from the systern was sustained from 12h to 9 days with IBU content in weight increasing from 5 to 20%. It seems that this is a prornising method to prepare drug controlled release systerns.
Microwave-assisted, ring-opening polymerization, poly(, ε-caprolactone), , maleic acid, succinic acid, adipic acid, ibuprofen, drug comtuolled release
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【期刊论文】Carbene polymerization: characterization of poly (carballyloxycarbene)†
刘立建, Lijian Liu, * Ying Song and Hao Li
Polym Int 51: 1047-1049 (2002),-0001,():
-1年11月30日
polymer (Mw3000g mol 1 with Mw/Mn 1.2) was obtained by the copper-catalyzed nitrogenelimination of allyl diazoacetate. Its structure was determined as poly (carballyloxycarbene) (PCACB) by 1H and 13C NMR and IR spectroscopy.
poly (, carballyloxycarbene), , carbene polymerization, characterization
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刘立建, Wei Jin, Lijian Liu*
Macromol. Biosci. 2004, 4, 656-664,-0001,():
-1年11月30日
The micro construction of poly(e-caprolactone) (PCL) and poly(L-lactic acid) (PLLA) blend films fabricated by solution casting under microwave irradiation was investigated by selective enzymatic degradation and scanning electron microscopy (SEM). The results were totally different from the blends obtained by conventional methods. The blend was more homogeneous and the PCL continuous phase more compact as no spherulites and tiny zone separation were observed from the film surface and no PCL network was observed inside the film, and the degradation of a PCL plank by Pseudomonas lipase was significantly retarded. The distributed PLLA micro spheres were enlarged and amorphous. The thermal behavior of the blend by microwave heating revealed that PCL and PLLA underwent a melting process, which induced the variations of the PCL phase and PLLA spheres.
blends, degradation, micro construction, microwave, poly (, ε-caprolactone), , poly (, L-lactic acid),
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【期刊论文】Rapid Ring-Opening Polymerization of D, L-Lactide by Microwaves
刘立建, Chao Zhang, Liqiong Liao, Lijian Liu*
Macromol. Rapid Commun. 2004, 25, 1402-1405,-0001,():
-1年11月30日
Poly(D,L-lactide) with a molar mass of 10 5g
degradation, D,, L-lactide, microwave, ring-opening polymerization
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【期刊论文】Microwave-Improved Polymerization of ∈-Caprolactone Initiated by Carboxylic Acids
刘立建, Z.J. YU, L.J. LIU, R.X. ZHUO
Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 41, 13-21 (2003),-0001,():
-1年11月30日
The ring-opening polymerization of ∈-caprolactone (∈-CL), initiated by carboxylic acids such as benzoic acid and chlorinated acetic acids under microwave irradiation, was investigated; with this method, no metal catalyst was necessary. The product was characterized as poly (∈-caprolactone) (PCL) by 1H NMR spectroscopy, Fourier transform infrared spectroscopy, ultraviolet spectroscopy, and gel permeation chromatography. The polymerization was significantly improved under microwave irradiation. The weight-average molecular weight (Mw) of PCL reached 44,800 g/mol, with a polydispersity index [weight-average molecular weight/number-average molecular weight (Mw/Mn)] of 1.6, when a mixture of ∈-CL and benzoic acid (25/1 molar ratio) was irradiated at 680W for 240min, whereas PCL with Mw 12,100 and Mw/Mn 4.2 was obtained from the same mixture by a conventional heating method at 210℃ for 240min. A degradation of the resultant PCL was observed during microwave polymerization with chlorinated acetic acids as initiators, and this induced a decrease in Mw of PCL. However, the degradation was hindered by benzoic acid at low concentrations.
microwave, ring-opening polymerization, polyesters, poly (, ∈-caprolactone), , biodegradable, benzoic acid
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【期刊论文】Heating Characteristics and Polymerization of ε-Caprolactone Under Microwave Irradiation
刘立建, L.Q. Liao, L.J. Liu, C. Zhang, F. He, R.X. Zhuo
Journal of Applied Polymer Science, Vol. 90, 2657-2664 (2003),-0001,():
-1年11月30日
The thermal effect of microwave energy on ε-caprolactone (CL) monomer and polymerization reaction mixture of CL with stannous octoate [Sn(Oct)2] intimately depended on the power level of microwaves and the mass scale of materials. When 10g of CL was heated by microwaves at a power of 680W, its temperature increased rapidly from 20 to 355℃ within 5 min after which it was self-regulated to keep constant at 360℃. Heat generation was observed when a polymerization reaction mixture of 10g CL with 0.1% (mol/mol) Sn (Oct) 2 was irradiated at 680W. The exothermic peak was recorded at 2-5min and its temperature was over 300℃, with the maximum at 343℃. During this period the ring-opening polymerization of CL occurred quickly, resulting in poly(ε-caprolactone) with weight-average molecular weight (Mw) of 123,000g/mol and yield of 95%.
ring-opening polymerization, polyesters, synthesis, caprolactone, microwaves
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【期刊论文】Microwave-Assisted Ring-Opening Polymerization of ∈-Caprolactone
刘立建, L.Q. LIAO, , L.J. LIU, C. ZHANG, F. HE, R. X. ZHUO, K. WAN
Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 40, 1749-1755 (2002),-0001,():
-1年11月30日
Ring-opening polymerization of ∈-caprolactone was carried out smoothly and effectively with constant microwave powers of 170, 340, 510, and 680 W, respectively, with a microwave oven at a frequency of 2.45GHz. The temperature of the polymerization ranged from 80 to 210℃. Poly (∈-caprolactone) (PCL) with a weightaverage molar mass (Mw) of 124,000g/mol and yield of 90% was obtained at 680W for 30min using 0.1%(mol/mol) stannous octanoate as a catalyst. When the polymerization was catalyzed by 1% (w/w) zinc powder, the Mw of PCL was 92,300g/mol after the reaction mixture was irradiated at 680W for 270min.
ring-opening polymerization, polyesters, synthesis, caprolactone, microwave, constant power
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刘立建, Suming Li, Lijian Liu, *, Henri Garreau, and Michel Vert
Biomacromolecules 2003, 4, 372-377,-0001,():
-1年11月30日
Poly (∈-caprolactone) was blended with various polylactide-based polymers and processed to films by the solution casting method. Blends of 25/75, 50/50, 75/25, 90/10, and 95/5 (w/w) poly(∈-caprolactone)/poly-(L-lactide), a 95/5 (w/w) blend of poly(∈-caprolactone) with a poly (D-lactide), a 50/50 (w/w) poly (L-lactide)-poly (D-lactide) mixture, and a poly (L-lactide-co-∈-caprolactone) copolymer were considered comparatively. The various phase-separated films were allowed to degrade in the presence of Pseudomonas lipase, biodegradation being monitored by proton nuclear magnetic resonance, size exclusion chromatography, differential scanning calorimetry, X-ray diffraction, and environmental scanning electron microscopy. The formation of separated phases during solvent evaporation and their morphologies are discussed. The introduction of poly(L-lactide) dramatically decreased the degradation rate of poly(∈-caprolactone)/poly (Llactide) blends. The higher the percentage of poly(L-lactide), the slower the degradation, while the presence of cracks and increasing the lipase concentration acted in favor of the enzymatic degradation. Long-term enzymatic degradation of the various 95/5 blends was investigated over 480 h. The poly(∈-caprolactone) phase was enzymatically degraded by the lipase regardless of the blend type, the degradation rate depending on the nature of the co-components.
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【期刊论文】Communications to the Editor
刘立建, Jiyan Liu and Lijian Liu*
Macromolecules 2004, 37, 2674-2676,-0001,():
-1年11月30日
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【期刊论文】Selective Enzymatic Degradations of Poly (L-lactide) and Poly (є-caprolactone) Blend Films
刘立建, Lijian Liu, †, Suming Li, *, Henri Garreau, and Michel Vert
Biomacromolecules 2000, 1, 350-359,-0001,():
-1年11月30日
Solution cast films were prepared from poly (L-lactide) (PLLA) and poly (є-caprolactone) (PCL) as well as from three blends, namely B75, B50, and B25 with PLLA/PCL proportions of 75/25, 50/50, and 25/75, respectively. The enzymatic degradation of square samples (10×10×0.2mm) cut from the films was investigated at 37℃ in a pH (8.6 Tris buffer containing proteinase K or in a pH) 7.0 hosphate buffer containing Pseudomonas lipase. It was confirmed that proteinase K can degrade amorphous domains of PLLA, but cannot degrade crystalline PLLA or PCL. In contrast, Pseudomonas lipase can degrade both amorphous and crystalline PCL but cannot degrade PLLA. The two faces of solution cast films showed different morphologies due to the solvent evaporation process. The lower face appeared more crystalline than the upper face because of the plasticizing effect of solvent entrapped inside which allowed crystallization to proceed. Therefore, the lower face was more resistant to enzymatic attack by proteinase K in the cases of PLLA and the blends. The two polymers in the blends exhibited well separated crystalline domains. PCL seemed to constitute the continuous phase of the blends with formation of large size spherulites when the PCL content was over 50%. The selective degradation of PCL or PLLA components revealed the inner morphology of the blends where microspherelike or islandlike patterns were observed.
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