赵昱，学者主页-中国科技论文在线

赵昱

主要研究方向为中药与天然药物化学，重要先导化合物的全合成、结构改造、构效关系研究，重要中药材活性成分或天然药物的生物转化，生物活性筛选研究，以及计算机辅助现代化中药与天然药物设计等。

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姓名：赵昱
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学位：
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博士生导师
职称：-
学科领域：

中药学
研究兴趣：主要研究方向为中药与天然药物化学，重要先导化合物的全合成、结构改造、构效关系研究，重要中药材活性成分或天然药物的生物转化，生物活性筛选研究，以及计算机辅助现代化中药与天然药物设计等。

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2280
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160
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8

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2008-01-25

【期刊论文】Synthesis of A/B Ring Analogs of Territrem B and Evaluation of their Biological Activities

赵昱

，-0001，（）：

-1年11月30日

摘要

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2005-03-08

【期刊论文】Eremophilane Derivatives with Novel Carbon Skeleton from Ligularia veitchiana

赵昱

，-0001，（）：

-1年11月30日

摘要

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2005-03-08

【期刊论文】Combination of HPLC-NMR Techniques on Phytochemical Analysis of Torreya jackii

赵昱

，-0001，（）：

-1年11月30日

摘要

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2005-03-08

【期刊论文】Eudesmane and megastigmane glucosides from Laggera alata

赵昱， Qunxiong Zheng a， c， Zhaojun Xu a， Xianfeng Sun b， Wei Yao a， Handong Sun b， Christopher H. K. Cheng d， Yu Zhao a， *

Phytochemistry 63(2003)835-839，-0001，（）：

-1年11月30日

摘要

This paper is dedicated to Professor Dr. Xiao-Tian Liang on the occasion of his 80th birthday. Abstract Four eudesmane glucosides, alatosides A-D (1-4), and one megastigmane glucoside, alatoside E (5), were isolated from the BuOH fraction of Laggera alata along with six known compounds. Structures of the new compounds were elucidated by a combination of chemical and spectroscopic methods. Alatosides A–E were characterized as: 1a-O-(b-d-glucopyranosyloxyl)-7-epi-eudesma-11-en-2b,4a-diol (1), 2b-O-(b-d-glucopyranosyloxyl)-eudesma-4a-hydroxyl-11(13)-en-12-oic-acid (2), 5b-O-(b-d-glucopyranosyloxyl)-eudesma-4(15),11(13)-dien-12-oic-acid (3), 5a-O-(b-d-glucopyranosyloxyl)-eudesma-3,11(13)-dien-12-oic acid (4) and 3b-O-(b-d-glucopyranosyloxyl)-megastigma-9-one (5), respectively. Based on the chemical characteristics of eudesmane derivatives isolated from the Laggera genus, it was suggested that there are probably two different biogenetic pathways for these secondary metabolites in this genus.

Laggera alata， Compositae， Eudesmane， Megastigmane， Alatoside

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2005-03-08

【期刊论文】Eudesmane Derivatives and Other Sesquiterpenes from Laggera alata

赵昱， Qun Xiong Zheng， †， § Zhao Jun Xu， † Xian Feng Sun， ‡ Francüoise Guéritte， ┴ Michele Cesario， ┴ Han Dong Sun， ‡ Christopher H. K. Cheng， || Xiao-Jiang Hao， ‡ and Yu Zhao*

J. Nat. Prod. 2003, 66, 1078-1081，-0001，（）：

-1年11月30日

摘要

Three new eudesmane sesquiterpenes, 5

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2005-03-08

【期刊论文】Syntheses of Two Cytotoxic Sinapyl Alcohol Derivatives and Isolation of Four New Related Compounds from Ligularia nelumbifolia

赵昱， Yu Zhao， *， †， ‡ Xiaojiang Hao， ‡ Wei Lu， § Junchao Cai， § Hong Yu， ┴ Thierry Sevénet， || and Francüoise Guéritte||

J. Nat. Prod. 2002, 65, 902-908，-0001，（）：

-1年11月30日

摘要

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.

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2005-03-08

【期刊论文】Lignans from Torreya jackii identified by stopped-flow high-performance liquid chromatography-nuclear magnetic resonance spectroscopy

赵昱， Yu Zhao a， Aslieh Nookandeh a， Bernd Schneider b， Xianfeng Sun a， Bettina Schmitt b， Joachim St

Journal of Chromatography A, 837(1999)83-91，-0001，（）：

-1年11月30日

摘要

Coupled reversed-phase HPLC-NMR spectroscopy has been applied to the rapid detection and identification of plant metabolites of Torreya jackii, a species of Taxaceae. Analysis consisted of gradient HPLC elution and directly coupled H NMR (500 MHz) spectroscopic detection in a stopped-flow mode. Seven lignans were detected and their structures were 1 elucidated, based on their HPLC-1 H NMR spectra and MS data. The structures were confirmed by isolation of the single components followed by conventional NMR measurements.

Torreya jackii， Nuclear magnetic resonance spectroscopy， Lignans

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2005-03-08

【期刊论文】Eudesmane derivatives from Laggera pterodonta

赵昱， Yecheng Xiao a， c， Qunxiong Zheng a， b， Qijun Zhanga， Handong Sunc， Fran

Fitoterapia 74(2003)459-463，-0001，（）：

-1年11月30日

摘要

A new eudesmane derivative, 4a,5a-dihydroxyeudesma-11(13)-en-12-oic acid, was isolated from Laggera pterodonta.Its structure was elucidated as (1) on the basis of spectroscopic evidence.Mor eover, six known compounds were isolated: pterodontriol A (2), pterodontriol B, pterodonta acid (3), ilicic acid (4), costic acid and b-amyrin.Cytotoxic activity of compounds 2, 3 and 4 was investigated.

Laggera pterodonta， 4a,， 5a-Dihydroxyeudesma-11(， 13)， -en-12-oic acid， Cytotoxic activity