陈道峰
中草药的活性成分、品质评价及新药研发
个性化签名
- 姓名:陈道峰
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
生物药物学
- 研究兴趣:中草药的活性成分、品质评价及新药研发
复旦大学药学院生药学教研室教授、博士生导师、主任,复旦大学药学院副院长。国家药典委员会委员、中国药典英文版副主编、中国药学会中药与天然药物专业委员会委员。1986年毕业于上海医科大学药学专业,1991年获中国药科大学生药学博士学位,同年任教于上海医科大学,1993年晋升为副教授,1997年晋升为教授,1999年遴选为博士生导师。1990、1998和2002年先后赴日本富山医科药科大学、美国阿拉巴马大学伯明翰分校和北卡罗莱那大学药学院合作研究。主要研究中草药的活性成分、品质评价及新药研发,主持和完成省部级以上科研项目近20项, 对中药鸡血藤和南五味子属药用植物的研究取得了一些高水平的研究成果,发表研究论文60余篇, 其中SCI论文20余篇(引用100余次),副主编译《中华人民共和国药典英文版》(2000, 2005)和《植物成分分析》等著作4部。曾获得国家中医药科技进步一等奖(1991)、保罗杨森药学研究生药学科三等奖(1997)。已培养和正在培养硕士生11名、博士生13名、博士后1名。曾获得上海市高校优秀青年教师奖、宝钢教育基金会优秀教师奖以及国务院政府特殊津贴,入选上海市科委科技启明星计划(1995)、教育部跨世纪人才培养计划(1996)和教育部高校优秀青年教师教学与科研奖励计划(1999)。
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成果阅读
1082
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成果数
15
【期刊论文】Pharmacognosnital studies on the Chinese Crued Drug “ji-xue-teng”(鸡血藤)
陈道峰
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-1年11月30日
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【期刊论文】New Myrsinol Diterpenes from Euphorbia prolifera
陈道峰, ZHANG, Wan-Jin, CHEN, Dao-Feng *, HOU Ai-Jun
Chinese Journal of Chemistry, 2004, 22, 103-108,-0001,():
-1年11月30日
Four new myrsinol diterpenes, euphorprolitherins A-D (1-3.5), were isolated from the ethanolic extract of the root of Euphorbth prolifera, along with a known one. SPr5 (4). The structures were elucidated on the bmis of their spectxoscopic evidences. The smlcture and relative stereochemistrv of 1 were confirmed by X-ray crystallog-raphy
Eupharbia prolifera,, Eupgorbthceae,, myrsinol diterpene,, euphorprolitherins A-D
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陈道峰, Yunqiu Yu, Peilan Ding, Daofeng Chen ∗
Analytica Chimica Acta 523(2004)15-20,-0001,():
-1年11月30日
A new capillary electrophoresis (CE) method for the determination of quinolizidine alkaloids in Sophora medicinal plants was developed. A total of seven alkaloid components (cytisine, sophocarpine, matrine, lehmannine, sophoranol, oxymatrine and oxysophocarpine) were separated within 15 min. The running buffer was a 50mMphosphate buffer containing 1%HP-β-CD and 3.3% isopropanol. The linear calibration ranges were 5.50-88.0µgml−1 for cytisine and lehmannine, 5.00-88.0[1]gml−1 for sophocarpine and sophoranol, 5.60-89.6µgml−1 for matrine and oxysophocarpine, and 24.0-384µgml−1 for oxymatrine. The recoveries of the seven alkaloids were 96.0-102.9% with relative standard deviations from 1.50 to 3.00% (n=5). The methodwas successfully applied to different Sophora medicinal plants including Sophora flavescens, Sophora tonkinensis and Sophora alopecuroides.
Capillary electrophoresis, Quinolizidine alkaloids, Sophora, Sophora flavescens, Quantitative assay
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【期刊论文】DIBENZOCYCLO-OCTADIENE LIGNANS FROM KADSURA HETEROCLITA
陈道峰, DAO FENG CHEN, GUO JUN XU, XIU-WEI YANG.* MASAO HATTORI, *, † YASUHIRO TEZUKA, * TOHRU KIKUCHI * and TSUNEO NAMBA *
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-1年11月30日
From the stems of Kadsura heteraclita, new dibenzocyclo-octadiene lignans, ndmed heteroclitins A-E, were isolated together with the known compounds, kadsurin and interiorin. Their structure, were determined by spectroscopic means
Kedsura hereroelita, Schizandraceae, stems, heteroclitin, dibenzoeyelo-octadiene lignan
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96浏览
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69浏览
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【期刊论文】Pharmacognosnital studies on the Chinese Crued Drug “ji-xue-teng”(鸡血藤)
陈道峰
,-0001,():
-1年11月30日
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60浏览
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陈道峰, Dao-Feng Chen, *, † Shun-Xiang Zhang, ‡ Mutsuo Kozuka, ‡ Quan-Zhong Sun, † Ju Feng, † Qiang Wang, † Teruo Mukainaka, § Yoshitaka Nobukuni, § Harukuni Tokuda, § Hoyoku Nishino, § Hui-Kang Wang, ‡ Susan L. Morris-Natschke, ‡ and Kuo-Hsiung Lee *, ‡
J. Nat. Prod. 2002, 65, 1242-1245,-0001,():
-1年11月30日
Two new lignans, interiotherins C (1) and D (2), together with the known compounds interiorin (3), heteroclitin F (4), neokadsuranin (5), heteroclitin D (6), kadsurin (7), gomisin A (8), schisandrin C (9), interiotherin A (10), angeloylgomisin R (11), gomisin G (12), interiotherin B (13), and gomisin C (14), were isolated from the stems of Kadsura interior. The structures and stereochemistries of the new compounds were determined from mass, CD, and NMR spectral data. Fourteen neolignans were screened as potential antitumor promoters by examining their ability to inhibit Epstein-Barr virus early antigen (EBV-EA) activation (induced by 12-O-tetradecanoylphorbol-13-acetate) in Rajicells. Neokadsuranin (5) and schisandrin C (9) were the most potent compounds. These data suggest that some neolignans might be valuable antitumor promoters or chemopreventors.
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【期刊论文】Novel Anti-HIV Lancilactone C and Related Triterpenes from Kadsura lancilimba
陈道峰, Dao-Feng Chen, *, † Shun-Xiang Zhang, ‡ Hui-Kang Wang, ‡ Shi-Yuan Zhang, † Quan-Zhong Sun, † L. Mark Cosentino, § and Kuo-Hsiung Lee *, ‡
J. Nat. Prod. 1999, 62, 94-97,-0001,():
-1年11月30日
Three new triterpene lactones, lancilactones A (1), B (2), and C (3), together with the known kadsulactone A (4), were isolated from the stems and roots of Kadsura lancilimba. Their structures and stereochemistries were determined primarily from mass and NMR spectral data. Compound 3 inhibited HIV replication with an EC50 value of 1.4
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【期刊论文】Two New Lignans, Interiotherins A and B, as Anti-HIV Principles from Kadsura interior
陈道峰, Dao-Feng Chen *, †, Shun-Xiang Zhang, ‡ Ke Chen, ‡ Bing-Nan Zhou, § Pei Wang, † L. Mark Cosentino, || and Kuo-Hsiung Lee *, ‡
Journal of Natural Products, 1996, Vol. 59, No.11,-0001,():
-1年11月30日
Two new lignans, interiotherins A (1) and B (2), along with two known lignans, angeloylgomisin R (3) and schisantherin D (4), were isolated from Kadsura interior. Their structures and stereochemistries were determined from spectral data. Compounds 1 and 4 inhibit HIV replication with EC50 values of 3.1 and 0.5
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