郎美东
组织工程材料、药物控释材料、不对称有机化学、有机合成、药物剂型
个性化签名
- 姓名:郎美东
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
高分子化学
- 研究兴趣:组织工程材料、药物控释材料、不对称有机化学、有机合成、药物剂型
郎美东,1966年8月生,祖籍浙江兰溪。1987年毕业于浙江师范大学;1993年获吉林大学理学硕士;1996年获吉林大学理学博士;1996年8月至1998年6月为中国科学院化学研究所博士后;1998年6月至2000年7月为美国康奈尔大学(Cornell University)博士后研究员;2000年7月至2002年5月美国密执根大学(University of Michigan)研究员;2002年7月复旦大学副教授;2003年7月华东理工大学教授。
专业为有机化学和高分子化学与物理;主要研究方向有:组织工程材料、药物控释材料、不对称有机化学、有机合成、药物剂型目前承担多项国家、省部级及中外合作科研项目。入选2004年度国家教育部新世纪优秀人才和上海市曙光学者。在J Am Chem Soc等国内外专业杂志上发表学术论文三十余篇,已被SCI刊物引用七十多篇次,申请国内外专利多篇。
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659
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成果数
15
郎美东, 朗美东, 顾青, 何耀, 黄维
,-0001,():
-1年11月30日
本发明公开了一种生物降解高分子材料的内酯单体,其以环己酮为起始原料,首先与丙烯酸苄酯加成得a-(丙酸苄酯基)环己酮,然后经氧化制得;或以a-取代环己酮为起始原料,先与苯甲醇进行酯交换反应,然后经氧化制得。本发明设计并合成的己内酯单体的最大优点在于,具侧链酯在水解时内酯键不受影响。此外,本发明还具有合成条件温和、安全;所用原料简单、廉价、丰富、易得等优点。
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郎美东, MEIDONG LANG, JIANZHONG BEI and SHENGUO WANG*
J. Biomater: Sci. Polyner Edn, Vol. 10, No.4, pp. 501-512 (1999),-0001,():
-1年11月30日
Polycaprolactone/poly (ethylene oxide)/polylactide tri-component copolymers (PCEL) with different compositions were synthesized by copolymerization of ε-caprolactone and L-lactide in the presence of poly (ethylene glycol) using stannous octoate as a catalyst. The copolymers were pnrified and characterized by various analytical techniques such as GPC, FT-IR, I H NMR, 13C NMR, DSC, and X-ray diffraetometry. It was evidenced that these eopolymers were pure tri-componcnt compounds which exhibited partially random chain structures, and possessed good mechanical properties and variable biodegradability.
Polycaprolactone, poly (, ethylene oxide), , polylactide, biodegradable,, copolylner, ring opening polymerization: enzymatic degradation.,
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【期刊论文】Form IV of Carbamazepine
郎美东, MEIDONG LANG, JEFF W. KAMPF, ADAM J. MATZGER
JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 91, NO.4, APRIL 2002,-0001,():
-1年11月30日
Carbamazepine has been found to crystallize as a new polymorph that is stable at room temperature. We report the crystal structure of this C-centered monoclinic form (space group C2/c, cell parameters: a=26.609, b=6.9269, c=13.957, b=109.702), which consists of hydrogen bonded dimers with an anti-disposition. This represents the third modification of carbamazepine that has been crystallographically characterized, and the fourth for which cell parameters have been determined. Thus, it is designated as form IV of carbamazepine. Differences between the packing of the various polymorphs are discussed.
carbamazepine, polymorphism, X-ray diffraction, crystal structure, hydrogen bond
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郎美东, MEIDONG LANG, * RENEE PUISAN WONG, † CHIH-CHANG CHU
Journal of Polymer Science: Part A: Polymer Chemistry, Vol. 40, 1127-1141 (2002),-0001,():
-1年11月30日
Hydroxyl-functionalized three-arm poly(∈-caprolactone)s (PGCL-OHs) were synthesized by the ring-opening polymerization of ∈-caprolactone in the presence of glycerol (as the core) and stannous octoate. The effect of the feed ratio of ∈-caprolactone to glycerol on the ring-opening polymerization was studied. These three-arm PGCL-OHs were then converted into double-bond-functionalized three-arm poly(∈-caprolactone)s (PGCL-Mas) by the reaction of PGCL-OH with maleic anhydride in the melt at 130℃. The quantitative conversion of hydroxyl functionality was achieved ata low mo lecular weight. The resulting PGCL-OH and PGCL-Ma were characterized with gel permeation chromatography, Fourier transforminfrared, 1H NMR, 13C NMR, and differential scanning calorimetry.
star polymers, polyesters, biodegradable, biomaterials
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【期刊论文】BIODEGRADABLE COPOLYMERS LINKED TO SEGMENT WITH A PLURALITY OF FUNCTIONAL GROUPS
郎美东, Meidong Lang, Chih-Chang Chu
,-0001,():
-1年11月30日
Biocompatible biodegradable polymer or copolymer is capped at one end has free hydroxyl at the other end. The free hydroxyl can be reacted to link a plurality of functional groups some or each of which can be reacted to attach directly or via a spacer molecule a moiety contaning an aminoxyl-contaning radical or to a moiety comprising other drug molecule residue or a moiety comprising other biologically active agent residue.
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郎美东, 王身国, 朗美东, 贝建中
权利要求书,1998,1~8,-0001,():
-1年11月30日
本发明涉及一种具有生物降解性的聚己内酯聚丙交酯-聚醚三元共聚物及其制法。用ε-己内酯或其衍生物同各种丙交酯或其混合物,以及烷撑氧聚醚,在催化剂异辛酸亚锡的作用和真空(低于13Pa)条件下,于110-170℃反应12-72小时,得到的聚己内酯-聚丙交酯-聚醚三元共聚物。其聚醚链段分子量可在44-22000之间调节,(聚己内酯+聚丙交酯)同聚醚的聚合单元比可在95:5M~45:55(mol%)之间调节,聚己内酯同聚丙交酯聚合单元比可在1:99~99:1(mol%)之间调节。此聚合物具有优良生物降解性能和力学性能,生物降解速度可以调节,且制备方法简易,便于生产。
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35浏览
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郎美东, ADAM L. GRZESIAK, MEIDONG LANG, KIBUM KIM, ADAM J. MATZGER
JOURNAL OF PHARMACEUTICAL SCIENCES, VOL. 92, NO.11, NOVEMBER 2003,-0001,():
-1年11月30日
For decades, carbamazepine (CBZ) has served as a model compound for groups engaged in the study of crystal polymorphism. Despite considerable effort, crystal structures for only three of its four anhydrous forms have previously been determined. Herein, we report the first single crystal X-ray structure of the high temperature modification of CBZ (form I). Form I crystallizes in a triclinic cell (P-1) having four inequivalent molecules with the following lattice parameters: a=5.1705(6), b=20.574(2), c=22.245(2)
olymorphism, crystal structure, X-ray diffractometry, calorimetry (, DSC), , hydrogen bond
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【期刊论文】Polymorphism of Nabumetone
郎美东, Christopher P. Price, Adam L. Grzesiak, Meidong Lang, and Adam J. Matzger*
Crystal Growth & Design, Vol. 2, No.6, 2002 503,-0001,():
-1年11月30日
The crystal structure of a new polymorph of nabumetone has been determined that displays dramatically lower stability yet differs only in weak intermolecular interactions from the known form.
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【期刊论文】The Use of Polymer Heteronuclei for Crystalline Polymorph Selection
郎美东, Meidong Lang, Adam L. Grzesiak and Adam J. Matzger*
J. AM. CHEM. SOC. 9 VOL. 124, NO.50, 2002 14835,-0001,():
-1年11月30日
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