褚良银
博士 教授
四川大学 化工学院
多相流旋转强化分离、微系统与控制释放、智能膜材料与膜过程等领域
暂无
- 姓名:褚良银
- 目前身份:在职研究人员
- 担任导师情况:
- 学位:博士
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学术头衔:
博士生导师, 享受国务院特殊津贴专家
- 职称:高级-教授
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学科领域:
勘探地球物理学
- 研究兴趣:多相流旋转强化分离、微系统与控制释放、智能膜材料与膜过程等领域
褚良银,1967年4月出生,湖北五峰人,土家族,九三学社社员,四川大学化工学院院长,二级教授、博士生导师。1989年7月毕业于成都科技大学(今四川大学),以专业第一名成绩保送读研究生。1992年3月在成都科技大学获硕士学位,1995年3月在东北大学获博士学位。1995年4月至1997年4月在四川大学做博士后,1999年9月至2001年9月在日本东京大学做博士后,2006年8月至2007年2月在美国哈佛大学做高级研究学者,2007年12月至2008年2月在法国巴黎ESPCI做访问教授,2011年11至12月在英国伯明翰大学做访问教授。2012年4月,被英国伯明翰大学特聘授予该校化学工程学院名誉教授(Honorary Professor, School of Chemical Engineering, University of Birmingham, UK)。2014年6 月,入选英国皇家化学会会士。
褚良银教授长期从事膜材料与膜过程、控制释放系统、微流控、传质与分离、生物材料等方面的研究工作,取得了一系列创新成果。迄今发表论文已被SCI收录153篇、EI收录162篇,其中在NatureCommunications等影响因子9.0以上国际顶尖刊物发表论文14篇,影响因子3.0以上重要刊物论文98篇(国际著名期刊封面论文7篇、封面导读论文5篇、封底论文4篇、扉页插图论文2篇)。申请中国专利28项(已授权21项)和国际专利8项(已授权3项)。出版学术专著4部(其中,国际著名出版社Springer邀请撰写英文专著2部),参编全国大型技术手册2部,参编中英文专著和教材等10部。
研究成果受到了国内外同行的广泛关注和重视,论著被国内外同行正面引用>3600次,其中,SCI他引>2400次(引用刊物包括Science、Nature Materials和Nature Nanotechnology等国际顶级期刊,引用作者包括发达国家科学院院士和工程院院士等著名专家),成果被Nature Materials作为“研究亮点(Research highlights)”专题报道。
被国际会议邀请做主题报告或邀请报告32次,被邀请担任国际会议学术委员会委员和分会主席35次。曾获省级科技进步奖一、二、三等奖各1项和部级自然科学奖二等奖1项。全国优秀博士学位论文指导教师,英国伯明翰大学名誉教授,中国化工学会理事。培养的博士生中有3人获得教育部博士研究生学术新人奖,3人获得四川省优秀博士学位论文奖,1人获得全国优秀博士学位论文提名奖,1人获得全国优秀博士学位论文奖。
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826
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成果数
13
褚良银, Yan Li, Liang-Yin Chu, * Jia-Hua Zhu, Hai-Dong Wang, Su-Lan Xia, and Wen-Mei Chen
Ind. Eng. Chem. Res. 2004, 43, 2643-2649,-0001,():
-1年11月30日
A series of thermoresponsive gating membranes, with a wide range of grafting yields, were prepared by grafting poly (N-isopropylacrylamide) (PNIPAM) onto porous poly (vinylidene fluoride) (PVDF) membrane substrates with a plasma-induced pore-filling polymerization method. The effect of grafting yield on the gating characteristics of thermoresponsive gating membranes was investigated systematically. The results showed that the grafting yield heavily affected both the water flux responsiveness coefficient and the thermoresponsivity of the membrane pore size. When the grafting yield was smaller than 2.81%, both the flux responsiveness coefficient and the thermoresponsivity of the membrane pore size increased with an increase in the grafting yield; however, when the grafting yield was higher than 6.38%, both the flux responsiveness coefficient and the thermoresponsivity of the membrane pore size were always equal to 1; i. e., no gating characteristics existed anymore. Diffusional permeation experiments showed that two distinct types of temperature responses were observed, depending on the grafting yield. The diffusional coefficient of a solute across membranes with low grafting yields increased with temperature, while that across membranes with high grafting yields decreased with temperature. To get a desired or satisfactory thermoresponsive gating performance, the membranes should be designed and prepared with a proper grafting yield.
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【期刊论文】Thermoresponsive Transport through Porous Membranes with Grafted PNIPAM Gates
褚良银, Liang-Yin Chu, Takuya Niitsuma, Takeo Yamaguchi, and Shin-ichi Nakao
April 2003 Vol. 49, No.4,-0001,():
-1年11月30日
Both thermoresponsive flat membranes and core-shell microcapsule membranes, with (N-isopropylacrylamide) (PNIPAM) a porous membrane substrate and grafted poly N-isopropylacrylamide PNIPAM gates, were successfully prepared using a plasma-graft pore-filling polymerization method. PNIPAM was prepared to be grafted homogeneously onto the porous membrane sub-strates, in the direction of both the membrane thickness and surface. Regardless of the solute molecular size, temperature had an opposite effection diffusion coefficients of the solute across the PNIPAM-grafted membranes with low graft yields as opposed to those with high graft yields. The PE-g-PNIPAM membranes change from positive thermo-response to negative thermoresponse types with increasing pore-filling ratios at around 30%. Phenomenological models were developed for predicting the diffusion coefficient of the solute across PNIPAM-grafted membranes at temperatures, both above and be-low the lower critical solution temperature LCST. Predicted diffusional coefficients of solutes across both the PNIPAM-grafted flat and PNIPAM-grafted microcapsule membranes fit the experimental values. To obtain an ideal result for the diffusional thermoresponsive controlled release through PNIPAM-grafted membranes, the substrates strong enough to prevent any conformation changes are more suitable for preparing thermoresponsive membranes than weak ones.
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褚良银, Liang-Yin Chu, * Yan Li, Jia-Hua Zhu, and Wen-Mei Chen
Angew. Chem. Int. Ed. 2005, 44, 2124-2127,-0001,():
-1年11月30日
Membranes with porous substrates and functional gates that are responsive to environmental stimuli are attracting increasing interest from various fields. Their permeation properties can be controlled or adjusted by the gates according to the external chemical and/or physical environment, and they may find various applications e.g. in controlled drug delivery, bioseparation, chemical separation, water treatment, tissue engineering, and as chemical sensors. The functional gates for stimuli-responsive membranes serve as chemical valves, and have been reported to act in response to changes in environmental temperature, [1-5] pH, [5-10] ionic strength, [11] glucose concentration, [12, 13] electric field, [14] light, [15] redox properties, [16] or different molecules. [17-19] There are many cases in which environmental temperature fluctuations occur naturally, and in which the temperature stimuli can be easily designed and artificially controlled; therefore much attention has recently been focused on thermoresponsive membranes. [2-1] Up to now, almost all of the thermoresponsive gating membranes have featured positively thermoresponsive characteristics, that is, the membrane permeability increases with increasing environmental temperature, because all of the thermoresponsive functional gates were constructed from poly (Nisopropylacrylamide) (PNIPAM). [1-5] In these cases, the membrane pores change from a "closed" to an "open" state when the environmental temperature increases from below the lower critical solution temperature (LCST) of PNIPAM to above the LCST, as a result of the swelling/shrinking conformational change of the polymer. In certain applications, however, an inverse mode of the thermoresponsive gating behavior of the membranes is preferred. Here we report a novel family of thermoresponsive gating membranes with negatively thermoresponsive gating characteristics, that is, "opening" of the membrane pores is induced by a decrease rather than an increase in temperature.
hydrogen bonds, membranesl, phase transitions, polymers
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【期刊论文】Preparation of glucose-sensitive microcapsules with a porous membrane and functional gates
褚良银, Liang-Yin Chu*, Yi-Jian Liang, Wen-Mei Chen, Xiao-Jie Ju, Hai-Dong Wang
Colloids and Surfaces B: Biointerfaces 37 (2004) 9-14,-0001,():
-1年11月30日
A glucose-sensitive microcapsule with a porous membrane and with linear-grafted polyacrylic acid (PAAC) chains and covalently bound glucose oxidase (GOD) enzymes in the membrane pores acting as functional gates was successfully prepared. Polyamide microcapsules with a porous membrane were prepared by interfacial polymerization, PAAC chains were grafted into the pores of the microcapsule membrane by plasma-graft pore-filling polymerization, and GOD enzymes were immobilized onto the PAAC-grafted microcapsules by a carbodiimide method. The release rates of model drug solutes from the fabricated microcapsules were significantly sensitive to the existence of glucose in the environmental solution. In solution, the release rate of either sodium chloride or VB12 molecules from the microcapsules was low but increased dramatically in the presence of 0.2mol/L glucose. The prepared PAAC-grafted and GOD-immobilized microcapsules showed a reversible glucose-sensitive release characteristic. The proposed microcapsules provide a new mode for injection-type self-regulated drug delivery systems having the capability of adapting the release rate of drugs such as insulin in response to changes in glucose concentration, which is highly attractive for diabetes therapy.
Microcapsule, Glucose-sensitive, Controlled-release, Functional gates, Plasma-graft polymerization
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褚良银, Xin-Cai Xiao, † Liang-Yin Chu, * Wen-Mei Chen, Shu Wang, and Rui Xie
Langmuir 2004, 20, 5247-5253,-0001,():
-1年11月30日
Wehave successfully prepared monodispersed thermoresponsive core-shell hydrogel microspheres with a mean diameter of 200-400nm with poly (N-isopropylacrylamide-co-styrene) [P (NIPAM-co-St)] cores and poly (N-isopropylacrylamide) (PNIPAM) shells. The submicrometer-sized monodispersed P (NIPAM-co-St) core seeds were prepared by using a surfactant-free emulsion polymerization method, and the PNIPAM shell layers were fabricated onto the core seeds by using a seed polymerization method. The particle size, morphology and monodispersity, and thermoresponsive characteristics of the prepared microspheres were experimentally studied. In the preparation of P (NIPAM-co-St) seeds, with increasing the initiator dosage, the mean diameters and the dispersal coefficients were almost at the same levels at first; however, when the initiator dosage increased further to a critical amount, the mean diameters decreased drastically and the monodispersity became worse significantly. With increasing the stirring rate, the particle diameter decreased, and when the stirring rate was larger than 600 rpm, the monodispersity became worse obviously. With increasing the phase ratio, the mean diameter became larger simply, and the monodispersity became worse first and then became better again. With increasing the reaction time, the particle sizes nearly did not change, while the monodispersity gradually became better slightly. For the core-shell microspheres, with increasing the NIPAM dosage in the preparation of the PNIPAM shell layers, the mean diameters became larger simply, the monodispersity became better, and the thermoresponsive swelling ratio of the hydrodynamic diameters increased.
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【期刊论文】A porous microcapsule membrane with straight pores for the immobilization of microbial cells
褚良银, Guang-Jin Wang, Liang-Yin Chu*, Wen-Mei Chen, Ming-Yu Zhou
Journal of Membrane Science 252 (2005) 279-284,-0001,():
-1年11月30日
A novel type of polyethersulfone porous microcapsule membranes with straight pores across the whole thickness was successfully prepared with a gel-sol phase inversion method for the immobilization of microbial cells. The mean diameter of the microcapsules was about 2mm, and the microcapsule membranes were full of straight finger pores. The pore size distribution was from 3.5 to 53.6m and the median pore diameter was 13.6m. The prepared microcapsules had large total pore volume, and total pore area and porosity (as large as 91.7%). The prepared porous microcapsules were used as carriers for the immobilization of microbial cells in the anaerobic wastewater biotreatment process. Immobilized anaerobic microbial cells were found both inside the membrane pores and in the inner spaces of microcapsules. The prepared porous microcapsules were proven to be efficient for the microbial immobilization under anaerobic conditions.
Polyethersulfone, Microcapsules, Porous membranes, Phase inversion, Microbial immobilization
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【期刊论文】Preparation of Micron-Sized Monodispersed Thermoresponsive Core-Shell Microcapsules
褚良银, Liang-Yin Chu, † Sang-Hoon Park, Takeo Yamaguchi, * and Shin-ichi Nakao
Langmuir 2002, 18, 1856-1864,-0001,():
-1年11月30日
Wehave successfully prepared monodispersed thermoresponsive core-shell microcapsules with a mean diameter of about 4μm with a porous membrane and with linear-grafted poly (N-isopropylacrylamide) (PNIPAM) chains in the membrane pores acting as thermoresponsive gates. The preparation was carried out by using a Shirasu porous glass (SPG) membrane emulsification technique to prepare small-sized monodispersed oil-in-water emulsions and using interfacial polymerization to prepare the core-shell microcapsules with porous membranes. Plasma-graft pore-filling polymerization was used to graft linear PNIPAM chains into the pores of the microcapsule membranes. In the SPG membrane emulsification process, theoptimumsurfactant sodium dodecyl sulfate (SDS) concentrationandpoly (vinyl alcohol) stabilizer concentration could be selected by solely considering the monodispersity of the emulsion droplets. However, before the interfacial polymerization process was started, these two oncentrations needed to be monitored to avoid any aggregation of the microcapsules and, if necessary, the appropriate quantity of SDS or Tween 80 needed to be added to prevent the microcapsules from aggregating in the interfacial polymerization stage. The prepared PNIPAM-grafted monodispersed microcapsules with a mean diameter of about 4μm showed satisfactory reversible and reproducible thermoresponsive release characteristics. The release of both NaCl and vitamin B12 (VB12) from the PNIPAM-grafted microcapsules was slow at 25℃ and fast at 40℃, which is due to the closed/open state of the grafted "gates". The "on/off" ratio of the release rate of VB12 from the PNIPAM-grafted microcapsules was much larger than that of NaCl.
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褚良银, Liang-Yin Chu, Sang-Hoon Park, Takeo Yamaguchi, Shin-ichi Nakao
Journal of Membrane Science 192 (2001) 27-39,-0001,():
-1年11月30日
A thermo-responsive core-shell microcapsule with a porous membrane and poly (N-isopropylacrylamide) (PNIPAM) gates was prepared using interfacial polymerization to prepare polyamide core-shell microcapsules, and plasma-graft pore-filling polymerization to graft PNIPAMinto the pores in the microcapsule wall. The proposed thermo-responsive microcapsule could be a positive thermo-response controlled-release one or a negative thermo-response one by changing the PNIPAM graft yield. When the graft yield is low, the release rate from the microcapsules is higher at temperatures above the lower critical solution temperature (LCST) than that below the LCST, due to the opened/closed pores in the microcapsule membranes controlled by the PNIPAM gates. In contrast, when the graft yield is high, the release rate is lower at temperatures above the LCST than that below the LCST, due to the hydrophilic/hydrophobic phase transition of the PNIPAM gates.
Microcapsule membrane, Thermo-responsive release, Poly (, N-isopropylacrylamide), , Interfacial polymerization, Plasma-graft pore-filling polymerization
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褚良银, Liang-Yin Chu*, Yan Li, Jia-Hua Zhu, Hai-Dong Wang, Yi-Jian Liang
Journal of Controlled Release 97 (2004) 43-53,-0001,():
-1年11月30日
The pore size and permeability control of a glucose-responsive gating membrane with plasma-grafted poly (acrylic acid) (PAAC) gates and covalently bound glucose oxidase (GOD) enzymes were investigated systematically. The PAAC-grafted porous polyvinylidene fluoride (PVDF) membranes with a wide range of grafting yields were prepared using a plasma-graft pore-filling polymerization method, and the immobilization of GOD was carried out by a carbodiimide method. The linear grafted PAAC chains in the membrane pores acted as the pH-responsive gates or actuators. The immobilized GOD acted as the glucose sensor and catalyzer; it was sensitive to glucose and catalyzed the glucose conversion to gluconic acid. The experimental results showed that the glucose responsivity of the solute diffusional permeability through the proposed membranes was heavily dependent on the PAAC grafting yield, because the pH-responsive change of pore size governed the glucose-responsive diffusional permeability. It is very important to design a proper grafting yield for obtaining an ideal gating response. For the proposed gating membrane with a PAAC grafting yield of 1.55%, the insulin permeation coefficient after the glucose addition (0.2mol/l) was about 9.37 times that in the absence of glucose, presenting an exciting result on glucosesensitive self-regulated insulin permeation.
Glucose-responsive, Insulin release, Gating membrane, Grafting yield, Gating characteristics
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【期刊论文】Positively Thermo-Sensitive Monodisperse Core-Shell Microspheres**
褚良银, By Xin-Cai Xiao, Liang-Yin Chu, * Wen-Mei Chen, Shu Wang, and Yan Li
Adv. Mater. 2003, 13, No.11, November,-0001,():
-1年11月30日
In this paper, we report on a novel family of monodisperse thermo-sensitive core-shell hydrogel microspheres that is featured with high monodispersity and positively thermo-responsive volume phase transition characteristics with tunable swelling kinetics, i.e., the particle swelling is induced by an increase rather than a decrease in temperature. The microspheres were fabri-cated in a three-step process. In the first step, monodisperse poly(acrylamide-co-styrene) seeds were prepared by emulsifier-free emulsion polymerization. In the second step, poly(acrylamide) or poly[acrylamide-co-(butyl methacrylate)] shells were fabricated on the microsphere seeds by free radical polymerization. In the third step, the core-shell microspheres with poly-(acrylamide)/poly(acrylic acid) based interpenetrating polymer network (IPN) shells were finished by a method of sequential IPN synthesis. The proposed monodisperse core-shell microspheres provide a new mode of the phase transition behavior for thermo-sensitive "smart" or "intelligent" monodisperse micro-actuators that is highly attractive for targeting drug delivery sys-tems, chemical separations, sensors, and so on.
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