梁宏
1、 血清白蛋白、漆树漆酶生物无机化学研究。 2、 纳米粒子的生物无机化学研究。 3、 钼和过渡金属功能配合物研究 。4、 中药无机化学、无机药物化学研究。
个性化签名
- 姓名:梁宏
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
- 职称:-
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学科领域:
无机化学
- 研究兴趣:1、 血清白蛋白、漆树漆酶生物无机化学研究。 2、 纳米粒子的生物无机化学研究。 3、 钼和过渡金属功能配合物研究 。4、 中药无机化学、无机药物化学研究。
梁宏,男,1964年12月生。1991年毕业于南开大学化学学院无机化学专业,获理学博士学位,师从申泮文院士。现任广西师范大学校长,广西师范大学化学化工学院教授,广西壮族自治区级重点学科化学学科的主要学科带头人。长期主讲研究生《生物无机化学》课程。1998年被聘任为中国化学会理事(2002年续聘)、广西化学化工学会副理事长。1999和2001年分别被聘任为中国化学会主办的国家核心期刊《化学通报》和《无机化学学报》编委,并被南开大学聘为兼职教授。2001年3月当选为广西化学化工学会理事长;2003年分别被聘为中国化学会无机化学学科委员会和应用化学学科委员会委员;2001年6月被中南大学应用化学和南开大学无机化学聘请为博士生导师。2004年5月被南京大学聘为无机化学博士生导师。先后指导12届共50余名硕士研究生,毕业9届共23名(17名考取南京、南开、兰州大学、中科院博士生),指导南开大学、南京大学和中南大学博士生共7名。1992年以来,梁宏博士主持国家自然科学基金课题4项, 参加1项;主持省(自治区)、厅级课题20多项。10余年来共发表论文约170多篇。在国际《Polyhedron》、《J. Inorg. Biochem.》、《Inorg. Chem. Commun.》和《Appl. Organometal. Chem.》和《中国科学》、《科学通报》等国内外核心期刊发表和录用100余篇,近90篇论文被综合性的国际自然科学索引SCI收录并被国内外学者引用。作为第一完成人,获广西科技进步一等奖一项、二等奖2项,广西科技进步三等奖、广西社会科学优秀成果三等奖和广西优秀教学成果三等奖各一次。1994 年被确定为"广西高校首批跨世纪学科带头人培养对象";1996年被评为 "广西壮族自治区优秀专家",同年享受国务院政府特殊津贴,并被国家人事部、国家科委、国家教委、中国科协、国家自然科学基金委等七部委确定为国家"百千万人才工程"第一、二层次人选,成为国家跨世纪学术和技术带头人重点培养对象;1998年被广西自治区政府确定为"广西十百千人才工程"第一层次人选;1999年被国家人事部授予"国家有突出贡献的中青年专家"的称号;同年,被授予"广西五四青年奖章"和"广西壮族自治区优秀专业技术人员"荣誉称号;2001年荣获"中国青年科技奖";2002年荣获教育部第三届"青年教师奖"(教育部新世纪人才);2004年荣获“第三届全国先进科技工作者”。
感兴趣的研究领域: 1、 血清白蛋白、漆树漆酶生物无机化学研究。 2、 纳米粒子的生物无机化学研究。 3、 钼和过渡金属功能配合物研究 4、 中药无机化学、无机药物化学研究
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10
梁宏, Hong Liang*, Qing Yu and Rui-Xiang Hu, Zhong-Yuan Zhou and Xiang-Ge Zhou
,-0001,():
-1年11月30日
The Schiff-base (PNOAAP) derived from picolinaldehyde N-oxide and 4-aminoantipyrine, and its copper(Ⅱ) complex: [Cu(PNOAAP)2(EtOH)2]2(ClO4)4 (1) has been prepared and characterized by elemental analysis, i.r., 1H n.m.r, spectrum, and single crystal X-ray crystallographic determination. The PNOAAP ligand isomerizes from trans to cis after chelating to copper(Ⅱ).
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【期刊论文】Binding equilibrium of I
梁宏, LIANG Hong, SHEN Xingcan, JIANG Zhiliang, HE Xiwen & SHEN Panwen
SCIENCE IN CHINA (Series B) December 2000 Vol. 43 No.6 600~608,-0001,():
-1年11月30日
The binding equilibrium between I- and human serum albumin (HSA) or bovine serum albumin (BSA) has been studied by means of the resonance Rayleigh scattering (RRS) and equi librium dialysis. It has been found for the first time that RRS and multiple frequency scattering (MFS) are enhanced as the I- binding to the HSA and BSA, but fluorescence quenches. The equilibrium dialysis results suggest that the binding of I
serum albumin,, iodine ion,, resonance Rayleigh scattering,, equilibrium dialysis,, phase distribution.,
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【期刊论文】Hysteresis effects of the interaction between serum albumins and silver nanoparticles
梁宏, SHEN Xingcan, , YUAN Qi, LIANG Hong, YAN Haigang & HE Xiwen
SCIENCE IN CHINA (Series B) August 2003 Vol. 46 No.4 387~398,-0001,():
-1年11月30日
The mechanisms and effects about the interaction between serum albumins and silver nanoparticles have been intensively studied by means of transmission electron microscopy (TEM), circular dichroism (CD) and ultraviolet-visible (UV-Vis) spectroscopy. The adsorption of serum albumins on the surface of silver nanoparticles is observed by TEM. The studies with the surface plasmon bands indicate that the electrostatic and hydrophilic interactions are the major forces between serum albumins and silver nanoparticles; the number of adsorbed monolayer serum albumin molecules to a silver nanoparticle with the size of 60nm is about 6.7
serum albumins,, silver nanoparticles,, hysteresis effect,, conformational transition,, surface plasmon band.,
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梁宏, HUANG Jin, YUAN Yuzhou & LIANG Hong
SCIENCE IN CHINA (Series B) April 2002 Vol. 45 No.2 200~207,-0001,():
-1年11月30日
The binding equilibrium between phosphotungstic acid (H7[P(W2OT)6]
serum albumin,, phosphotungstic acid,, UV spectrum,, fluorescence spectrum,, equilibrium dialysis.,
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【期刊论文】Crystal structure of zinc(Ⅱ) complex with thiosemicarbazone of acetone
梁宏, Hong Liang a*, Bin Liu a, Rui-Xiang Hu a and Kai-Bei Yu b
J. Indian Chem. Soc., Vol. 77, October 2000, pp. 486-487,-0001,():
-1年11月30日
Synthesis and crystal structure determination of the title complex are presented. It shows that the zinc atom located in the distorted tetrahedral coordination, is composed of two nitrogen atoms and two sulfur atoms from the two ligand.
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【期刊论文】Studies on the interaction between Ag and human serum albumin
梁宏, Xing-Can Shen a, b, Hong Liang b, Jun-Huai Guo a, Cheng Song b, Xi-Wen Hea a, *, Yu-Zhou Yuan b
Journal of Inorganic Biochemistry 95 (2003) 124-130,-0001,():
-1年11月30日
The interaction between Ag+ and human serum albumin (HSA) has been intensively studied by means of equilibrium dialysis, ligand-to-metal charge transition (LMCT) bands, circular dichroism (CD) and Raman spectroscopy. Scatchard analysis of the results of 1 equilibrium dialysis indicates the presence of two types of binding sites for Ag+ on HSA, and the orders of magnitude of binding stability 54 constants are found to be 10 5 and 10 4, respectively. During the binding process, a gradual increase in absorbance values of LMCT bands is observed with time-scanning UV absorption spectra, implying the Ag(Ⅰ) centers are continually formed in HSA. The time-scanning CD1 spectra provide evidence that the binding of Ag+ induces HSA to undergo a slow rearrangement of tertiary structure, and to change from 11 the original conformation in the absence of Ag (B-state) to conformation binding with Ag (A-state). The rate constants and activation free energy of A-B transition are calculated. The Raman spectrum of Ag(Ⅰ)-HSA system shows distinct vibration bands at 224 and 246 21cm in the low-frequency region, which significantly reveal the formation of Ag-S and Ag-N bonds. In addition, the electrostatic 1 interaction between Ag+ and negatively charged oxygen is also detected with Raman spectroscopy.
Ag(, Ⅰ), -serum albumin, Equilibrium constant, Conformation transition, Activation free energy, Coordination analysis
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梁宏, Hong Liang a, *, Jin Huang a, Chu-Qiao Tu a, Min Zhang a, Yong-Qia Zhou b, Pan-Wen Shen b
Journal of Inorganic Biochemistry 85 (2001) 167-171,-0001,():
-1年11月30日
A notable hysteretic effect has been observed in the interaction of Co(Ⅱ) with human serum albumin (HSA) or bovine serum albumin (BSA) using UV-Visible spectrometry at physiological pH (7.43), which shows that the binding between Co(Ⅱ) and HSA or BSA may induce a slow transition of HSA or BSA from the conformation of weaker affinity for Co(Ⅱ) to one of stronger affinity (A-B transition). The rate constants and activation parameters of this transition were measured and are discussed. It is inferred that such a conformation transition may occur due to the binding of the first Co(Ⅱ) ion with the peptide segment of N-terminal residues 1-3, which results in a 'hinged movement' of the relatively hydrophobic 'valley' in the IA subdomain. This process leads to a slow conformational transition in the albumins, makes the other binding sites of Co(Ⅱ) exposed, and shows a positive cooperativity effect. The LMCT (ligand-to-metal charge transition) bands of the Co(Ⅱ)-HSA and Co(Ⅱ)-BSA systems also show a kind of hypochromic effect featuring a dipole-dipole interaction mechanism. This phenomenon is rarely reported.
Co(, Ⅱ), -serum albumin, Hysteretic effect, Conformation transition, Hypochromic effect
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梁宏, Zhen-Feng Chen a, c, , Hong Liang a, *, Huai-Ming Hu b, Yan Li b, Ren-Gen Xiong c, Xiao-Zeng You c
Inorganic Chemistry Communications 6 (2003) 241-243,-0001,():
-1年11月30日
The hydrothermal reaction of norfloxacin (H-Norf) with NH4VO3 yields an unprecedented neutral nanosized molecular square grid containing a direct coordinate bond between quinololine drug and V(Ⅱ), V(Norf)2·2H2O 1, which is characterized by single Xray determination and IR spectrum as well as TGA.
Crystal structure, Norfloxacin, Vanadium(, Ⅱ), complex, Hydrothermal synthesis
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梁宏, Xing-Can Shen, Xiu-Zhong Fang, Ying-Hua Zhou, and Hong Liang
Chemistry Letters Vol. 33, No.11 (2004) 1468~1469,-0001,():
-1年11月30日
The aminosilane-modified magnetite nanoparticles were synthesized by the coprecipitation and surface modification with 3-aminopropyltriethoxysilane (APTTS). The superparamagnetic APTTS/Fe3O4 nanospheres with an average diameter of 10nm were characterized significantly with functional group, well dispersion and stabilization in aqueous fluids, as well as a maximized saturation magnetization of 63.54emu/g.
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梁宏, LIANG, Hong*, CHEN, Xiong-Bin, Zhen-Feng, HU, Rui-Xiang, YU, Kai-Bei
CHINESE JOURNAL.OF CHEMISTRY 2002, 20, 650-656,-0001,():
-1年11月30日
The reaction of picolinic acid (Hpic) and (n-Bu4N)4[MosO26] in the presence of CH3CN gave a supramolecular compound (n-Bu4N)2[Mo2O6(pic)2] (1), and its structure was characterized by elemental analysis, IR spectra and single crystal Xray diffraction analysis. The single crystal X-ray diffraction study shows that the crystal is in monocnnic crystal system, P21/c space group with cell parameters a=0.9941 (2), b=1.3719(2), c=1.8824(2)nm, β=100.840(10)°, Mr=508.50, V=2.5214(9)nm3, F(000)=1072. Compound 1 is a dimer through two μ2-O bridging to two MoO3 (pic)-unit, then connected one-dlmensional anion-chain by undassical hy-drogen bonding, and the anion-chain across the channels formed via (n-Bu4N)+ cations. By means of undassical hydrogen bonding, the anion-chain and cationchannels assemble into three-dimensional supramolecular networks.
molybdenum (, Ⅵ), complex,, crystal structure,, hydrogen bonding,, supramolecular networks
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