曾益新
抗癌药物研究及鼻咽癌研究
个性化签名
- 姓名:曾益新
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师
- 职称:-
-
学科领域:
肿瘤学
- 研究兴趣:抗癌药物研究及鼻咽癌研究
曾益新,男,1962年10月生,籍贯湖南,1990年毕业于中山医科大学,获医学博士学位。1992年~1997年在日本、美国留学期间,在抑癌基因p21的调控机制和乳腺癌易感基因BRCAL的作用机理方面获得国际原创性发现,在Oncogene、 Nature Genetics等国际权威杂志上发表多篇学术论文。
1997年回国后,在中山大学肿瘤防治中心工作至今,现为该中心主任、院长,实验研究部主任、生物治疗中心主任,博士生导师。作为中山大学肿瘤学科的学科带头人,使该学科在近些年有快速的发展,并成为国家重点学科,并与美国著名的M.D. Anderson癌症中心结成姐妹医院,开展全方位的合作。
1997年至今先后获得了国家杰出青年基金、863及973等国家级和省市科研基金的支持,总共获得的科研经费超过二千万元人民币。同时他在抗癌药物研究及鼻咽癌研究方面也取得了重要的成绩,在国际肿瘤学期刊上发表了多篇论文,并获得了国际专利。尤其是鼻咽癌易感基因的成功定位,获得国际学术界的认同,相关论文发表在2002年8月的国际权威的《Nature Genetics》杂志,其“鼻咽癌分子遗传学研究”获得2002年教育部国家自然科学奖一等奖,2003年广东省科学技术奖一等奖,2004年中华医学会科技奖一等奖,这一成果被评为2002年中国医药卫生十大科技新闻和2002年中国高等学校十大科技进展。
主编肿瘤核心期刊《癌症》杂志,2002年《癌症》杂志并被录入Medline/Index Medicus。主编卫生部研究生规划教材《肿瘤学》(第一版1999、第二版2002)被评为2002年教育部全国高等学校优秀教材评选二等奖,受到肿瘤学界一致好评。
-
主页访问
3294
-
关注数
0
-
成果阅读
341
-
成果数
10
-
42浏览
-
0点赞
-
0收藏
-
0分享
-
186下载
-
0评论
-
引用
【期刊论文】Familial nasopharyngeal carcinoma
曾益新, Yi-Xin Zeng* and Wei-Hua Jia
seminars in CANCER BIOLOGY, Vol. 12, 2002: pp. 443-450,-0001,():
-1年11月30日
Nasopharyngeal carcinoma (NPC) has a striking geographical and ethnical distribution. It occurs with high frequency in southern China and Southeast Asia. Family clustering was also observed in NPC and a typical family with 15 NPC cases was introduced in this paper. Epidemiological and genetic studies have been carried out in the previous decades and vast information was accumulated for familiar NPC, in terms of risk factors, inheritance mode, and involvement of gene polymorphisms. The major findings in this field were summarized. Furthermore, future directions leading to understanding the genetic mechanism of the familial form of NPC was also discussed.
Cantonese/, epidemiology/, familial/, nasopharyngeal carcinoma
-
43浏览
-
0点赞
-
0收藏
-
0分享
-
244下载
-
0评论
-
引用
曾益新, Bing Jian Feng*, Wei Huang, *, Yin Yao Shugart*, Ming K. Lee*, Feng Zhang*, Jian Chuan Xia, Hui Yun Wang, Teng Bo Huang, Shao Wen Jian, Ping Huang, Qi Sheng Feng, Li Xi Huang, Xing Juan Yu, Duang Li, Li Zheng Chen, Wei Hua Jia, Yan Fang, Hui Ming Huang, Jing Liu Zhu, Xiao Ming Liu, Yan Zhao, Wang Qing Liu, Mang Quan Deng, Wei Han Hu, Shao Xiong Wu, Hao Yuan Mo, Ming Fang Hong, Mary Claire King, Zhu Chen and Yi Xin Zeng
,-0001,():
-1年11月30日
Nasopharyngeal carcinoma (NPC) occurs with high frequency in Asian populations, especially among people of Cantonese ancestry. In areas with high incidence, NPC clusters in families, which suggests that both geography and genetics may influence disease risk1-6. Although the HLA-Bw46 locus is associated with increased risk of NPC7,8, no predisposing genes have been identified so far. Here we report the results of a genome-wide search carried out in families at high risk of NPC from Guangdong Province, China. Parametric analyses provide evidence of linkage to the D4S405 marker on chromosome 4 with a logarithm of odds for linkage (Iod) score of 3.06 and a heterogeneity-adjusted Iod (hlod) score of 3.21. Fine mapping with additional markers flanking D4S405 resulted in a lod score of 3.54 and hlod score of 3.67 for the region 4p15.1-q12. Multipoint nonparametric linkage analysis gives Iod scores of 3.54 at D4S405 (P=5.4
-
39浏览
-
0点赞
-
0收藏
-
0分享
-
143下载
-
0评论
-
引用
【期刊论文】鼻咽癌c-myc和c-erbB-2过表达与染色体多体性的关系
曾益新, 张林杰*, 鄢践*, 粱启万, 黄必军, 李辉梅, 方嬿†
科学通报,2001,46(20):1721~1724,-0001,():
-1年11月30日
以往研究提示,c-myc和c-erbB-2癌基因在鼻咽癌中过表达。为了阐明这两种癌基因过表达的分子机制,应用当前肿瘤研究新技术——组织微阵列,结合间期双色荧光原位杂交(FISH)和免疫组化(IHC),对267例鼻咽癌组织、24例癌旁组织和29例鼻咽部慢性炎症组织进行了大样本研究。结果发现,号咽癌c-myc和c-erbB-2癌蛋白过表达发生率分别为48%¥~63%和20%~38%;但c-myc和c-erbB-2两个癌基因在鼻咽癌中均无扩增;8与17号着丝粒探针杂交则分别显示有43%~50%和20%~27%的鼻咽癌染色体呈现多体性。蛋白表达分析表明,c-erbB-2表达与17号染色体多体性有关(P<0.0005)。
鼻咽癌, c-myc, c-erbB-2, 组织微阵列, 染色体多体性
-
54浏览
-
0点赞
-
0收藏
-
0分享
-
128下载
-
0评论
-
引用
【期刊论文】Absence of evidence for HER2 amplification in nasopharyngeal carcinoma
曾益新, Jian Yan, Yan Fang, Bi-Jun Huang, Qi-Wan Liang, Qiu-Liang Wu, Yi-Xin Zeng*
Cancer Genetics and Cytogerctics 132(2002)116-119,-0001,():
-1年11月30日
HER2 (c-erbB-2) has been suggested to be a prognostic factor in a variety of human cancers including breast, gastric and ovarian cancers. This study is therefore designed to ide~ntify changes of HER2 in nasopharyngeal carcinoma (NPC). an epithelia-derived malignancy with strong racial and geographic distribution. Interphase FISH and immunriohistochemical (IHC) staining were used to analyze the gene copy number and protein expression of HER2 in 45 cases of NPC from Guangzhou. Southern China. an area with the highest incidence of NPC in the world. Our results, however, found no significant alterations in gene copy number for HER2, although IHC staining detected expression of HER2 oncoprotein in 33% Of the 45 NPC tumors. No correlation was observed between HER2 expression and sex, age and clinical outcome of the patients. T stage, lymph node status, site and histopathological grading of-the tumors. These results cast doubt on the value of HER2 as a prognostic factor for NPC.
-
29浏览
-
0点赞
-
0收藏
-
0分享
-
128下载
-
0评论
-
引用
曾益新, Xiao-Qiong LIU, , Han-Kui CHEN, Xiao-Shi ZHANG, Zhi-Gang PAN, Ang Li, Qi-Sheng FENG, Qing-Xin LONG, Xun-Zhang WANG and Yi-Xin ZHNG*
Int. J. Cancer: 106, 000-000(2003),-0001,():
-1年11月30日
Nonrandom allelic loss on chromosome 3p is a common event in nasopharyngeal carcinoma (NPC) with the implication that certain tumor suppressor gene(s) in this region are involved in the pathogenesis of these tumors, The BLU gene, located at 3p21.3, has recently been identified as a candidate tumor suppressor gene due to the occurrence of missense mutations and loss of its expression in lung cancer. To investigate the involvement of BLU gene in NPC, we examined tumors and cell lines. No pathogenic mutations were detected in the entire coding region of this gene in 45 primary NPC tumors and 5 NPC cell lines. While BLU was expressed in 100% (15 of 15) of noncancerous nasopharyngeal epithelia, its transcripts were missing in all 5 NPC cell lines, and absent or reduced mRNA levels were observed in 78% (2B of 36) of the primary tumors. In the NPC cell lines, loss of BLU expromoter sequence, and expression was restored after treatment with 5-aza-2-deoxycytidine. Methylation specific PCR analysis revealed that the BLU promoter was highly methylated in 74% (17 of 23) of primary tumors in which BLU was downregulated, whereas only 2 of 9 non-neoplastic nasophamoter region. The high incldence of BLU alterations suggests that it may be one of the critical tumor suppressor genes on chromosome 3p21.3 involved in the development of NPC.
nasopharyngeal carcinoma, tumor suppressor gene, mutation, gene expression, methylation
-
27浏览
-
0点赞
-
0收藏
-
0分享
-
66下载
-
0评论
-
引用
曾益新, YAN Jian, FANG Yan, LIANC Qiwan, HUANC Yixue and ZENC Yixin
Chinese Medical Journal 2001; 114(4):418-421,-0001,():
-1年11月30日
Objective To gain a better understanding of genetic changes in Cantonese nasopharyngeal carcinoma (NPC). Methods Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas.Results A novel copy number gain an chromosome 4q and loss of chromosome lp were found at a high frequency (>50%). Conclusions Current analysis revealed a comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and lq as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.
nasopharyngeal carcinoma•comparative genornic hybridization•chromosomal alteration
-
28浏览
-
0点赞
-
0收藏
-
0分享
-
75下载
-
0评论
-
引用
曾益新, JIAN-YONG SHAO, , XIAO-MING HUANG, XING-JUAN YU, LI-XIN HUANG, QIU-LIANG WU, JIAN-CUAN XIA, HUI-YUN WANG, QI-SHENG FENG, ZE-FANG REN, INGEMAR ERNBERG, LI-FU HU and YI-XIN ZENG
ANTICANCER RESEARCH 21:3021-3030(2001),-0001,():
-1年11月30日
carcinomas (NPC) were examined by a lleIotype analysis for the ptuposes of detecting potential association between loss of heterozygosity (LOH), clinicopathological parameters and Epstein-Barr virus (EBV) infection. LOH was performed using 257 polymorphic markers on 22 chromosomes. High frequency LOH (≥60%) was observed on 12 chromosome arms including 1p, 2p, 2q, 3p, 3q, 5q, 9p, 9q, 1 lq, 13q, 14q and 17q, with the highest LOH frequency of 91% on 3p. Seventy-three loci presented LOH frequency≥30%; most of these loci clustered on 1p36 p34, 2p25-p24, 3p14-p21, 3p24-p26, 5q11-q14, 5q31-q33, 9p21-p23, 9q33-q34, 11q23-q25, 13q12 q14, 13q31-q33, 14ql3-q11, 14q32 and 19q13. On 1p36-p34, 2p25-p24, 5qI3-q11, 5q31-q33 and 19q13 are reported for the first time. LOH was correlated with specific clinicopathological parameters including tumor T-stage, N-stage, TNM-stage, tumor differentiation and serum antibody titers of IgA against vires capsid antigens (VCA) and early antigen (EA) of EBVin NPC (LOH frequency≥30%). Significantly high LOH frequency was observed on 9p21 (56%) and 19q13 (50%) in NPC with stage T3+T4, while significantly higher LOH frequency was observed on 12p11 (65%) in NPC with stage T1+T2. Significantly higher LOH frequency on 19q13 was also observed in NPC with advanced TNM-stage (Ⅲ+Ⅳ). High fractional allelic loss (FAL) value and high antibody titers of EBV IgA/VCA and/or IgA/EA were significantly correlated with T3+T4-stage, distant lymph node metastasis and advanced TNM-stage of NPC. We also found that NPC patients with high titers of IgA/VCA and IgA/EA showed high LOH frequency on 16q (48%) and 19q13 (48%). These results suggest that LOH on 9p21, 16q and 19q13 may be responsible for the aggressiveness and progression of NPC; there may be an interaction between
Loss of heterozygosity,, nasopharyngeat carcinoma,, Epstein-Barr virus,, clinical outcome.,
-
30浏览
-
0点赞
-
0收藏
-
0分享
-
80下载
-
0评论
-
引用
曾益新, Fang Y, Guan XY, Guo Y, Sham JS, Deng M, Liang Q, Li H, Zhang H, Zhou H, Trent J
Genes Chromosomes Cancer 2001 Mar; 30(3):254-260,-0001,():
-1年11月30日
To identify genetic alterations associated with the development and progression of human nasopharyngeal carcinoma (NPC), 57 tumors were analyzed by comparative genomic hybridization (CGH). In 47 cases, chromosomal imbalances were found. Several recurrent chromosomal abnormalities were identified in the present study. The most frequently detected chromosomal gains involved chromosome arms 12q (24 cases, 51%), 4q (17 cases, 36%), 3q (16 cases, 34%), 1q (15 cases, 32%), and 18q (15 cases, 32%). Common regions of gain involved 12q13-q15, 4q12-q21, and 3q21-q26. High-copy-number increases of chromosomal materials were detected in four chromosomal regions, 3q21-q26.2, 4p12-q21, 8p, and 12q14-q15. The most frequently detected loss of chromosomal materials involved chromosome arms 16q (26 cases, 55%), 14q (21 cases, 45%), 1p (20 cases, 43%), 3p (20 cases, 43%), 16p (19 cases, 40%), llq (17 cases, 36%), and 19p (16 cases, 34%). The most common regions of loss involved 14q24-qter, 1pter-p36.1, 3p22-p21.3, 11q21-qter, and the distal region of 19p. Genomic alterations detected by CGH were compared and found to be largely consistent with those identified in banding analysis and loss of heterozygosity studies. However, several previously unrecognized recurrent alterations were also identified in the present study, including gain of 4q and 18q, and loss of 16q, 14q, and 19p. In addition, gain of lq, 8q, 18q, and loss of 9q showed a statistically significant association with advanced clinical stages (P<0.05). Identification of recurrent sites of chromosomal gain and loss identify regions of the genome that may contain oncogenes or tumor suppressor genes, respectively, which may be involved in the tumorigenesis of NPC. Published 2000 Wiley-Liss, Inc.
-
20浏览
-
0点赞
-
0收藏
-
0分享
-
80下载
-
0评论
-
引用
曾益新, JIAN-YONG SHAO*, HUI-YUN WANG*, XIAO-MING HUANG, QI-SHENG FENG, PING HUANG, BING-JIAN FENG, LI-XI HUANG, XIN-JUAN YU, JING-TIAN LI, LI-FU HU, INGEMAR ERNBERG and YI-XIN ZENG
INTERNATIONAL JOURNAL OF ONCOLOGY 17:1267-1275, 2000,-0001,():
-1年11月30日
Nasopharyngeal carcinoma (NPC) is one of the most common malignant tumors in Southern China, especially in the Guangdong area. To demonstrate a comprehensive profile of loss of heterozygosity (LOH) in NPC, we applied a large panel of 382 microsatellite polymorphism markers covering all the 22 autosomes in 98 cases of sporadic primary NPC. Of the 335 informative markers, 83 loci showed high level of LOH (presence in equal to or more than 30% cases) and most of the high frequent loci were clustered to chromosome 1p36 and 1p34, 3p14-p21, 3p24-p26, 3q25-q26 and 3q27, 4q31 and 4q35, 5q15-21 and 5q32-q33, 8p22-p23, 9p21-p23 and 9q33-q34, llp12-p14, 13q14-q13 and 13q 31-q32, 14q13-q11, 14q24-q23 and 14q32. High frequency of LOH was found in chromosomes 3, 5, 9 and 11 (≥50%), while medium frequency of LOH was found in chromosomes 1, 4, 6, 14, 17 and 19 (40-49%). Several new regions showing high frequency of LOH were found in chromosome 1p36, 3q25-q26, 3q27, 5q15-q21, 8p22-p23 and 11p12-14. The relationship between LOH and TNM stage of NPC was evaluated. Regions 6p23 (D6S289), 8p23.1 (D8S549) and 9q34.2 (D9S1826) showed higher frequency of LOH in later stages (Ⅲ and Ⅳ) than in earlier stages (Ⅰ and Ⅱ) (P<0.05). Thus, our study provides a global view on allelic loss in the development of NPC and should shed light on the way for localization of putative tumor suppressor genes associated with the pathogenesis of NPC.
-
29浏览
-
0点赞
-
0收藏
-
0分享
-
82下载
-
0评论
-
引用