何炳林
1. 大孔离子交换树脂的合成、结构、性能与应用;2. 新型吸附树脂的合成、结构、性能与应用;3. 高分子催化剂的结构与催化活性;4. 生物医用材料与性能及其在血液净化与控制释放的应用;5. 离子交换的反应动力学研究。
个性化签名
- 姓名:何炳林
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学术头衔:
博士生导师, 中国科学院院士
- 职称:-
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学科领域:
高分子化学
- 研究兴趣:1. 大孔离子交换树脂的合成、结构、性能与应用;2. 新型吸附树脂的合成、结构、性能与应用;3. 高分子催化剂的结构与催化活性;4. 生物医用材料与性能及其在血液净化与控制释放的应用;5. 离子交换的反应动力学研究。
何炳林,男,1918年8月生于广东番禺。高分子化学家,中国科学院院士(1980年当选),南开大学教授。1942年毕业于西南联合大学,1952年获美国印第安那大学博士学位。现为《离子交换与吸附》主编、《高等学校化学学报》副主编、《Reactive & Functional Polymers》编委,曾任《中国科学》、《科学通报》、《高分子学报》及《Biomaterials, Artificial Cells and Artificial Organs》等重要学术刊物的编委或副主编。曾担任南开大学高分子研究所所长、中国化学会高分子化学委员会副理事长、高分子科学委员会副主任、中国科学院化学部委员及常委、中国生物材料与人工器官学会副理事长、兼任青岛大学校长等职。长期从事高分子化学教学与研究工作。为南开大学高分子化学研究所、高分子国家重点学科及吸附分离功能高分子材料国家重点实验室的建立作出了重要贡献。开创了我国的离子交换树脂事业。在国内最早开展聚苯乙烯型离子交换树脂的研制,以他的研究成果建立的南开大学化工厂是我国第一个离子交换树脂生产厂,并将离子交换树脂生产技术普及到全国,不仅使离子交换树脂成功地用于核燃料铀的提取,而且还广泛用于其他民用工业部门。1956~1958年期间,在研究提高离子交换树脂的强度已减少放射性元素辐射的破坏作用时,首次发现“烯烃和双烯烃在惰性溶剂或高聚物存在下进行自由基共聚,得到的交联共聚物为大孔结构”,从而制备出大孔型离子交换树脂,同时为今天已广泛使用的大孔吸附树脂的诞生奠定了理论和技术基础。研究方向包括:1. 大孔离子交换树脂的合成、结构、性能与应用;2. 新型吸附树脂的合成、结构、性能与应用;3. 高分子催化剂的结构与催化活性;4. 生物医用材料与性能及其在血液净化与控制释放的应用;5. 离子交换的反应动力学研究。在国内外已发表科研论文700多篇,获得十多个专利。获科研及教学奖三十多项,其中包括:1.大孔离子交换树脂及新型吸附树脂的合成、结构与性能的研究(1987年获国家自然科学二等奖);2.除草剂一号的研究(1964年获国家科委一等奖);3.献身国防科学技术(1989年获解放军国家科学技术工业委员会荣誉奖);4.离子交换树脂(1978年获六项科学大会奖);5.新型大孔离子交换树脂(1979年获天津市科技成果一等奖);6.国家自然科学基金重大项目“生物医用基础研究”(1998获国家教委一等奖);7. 1997年获何梁何利科学技术进步奖;8.高选择性吸附分离功能高分子材料(2000年获科技部杜邦科技创新奖);9.若干生物医学高分子研究(1999年获国家自然科学三等奖);10.选择性吸附树脂血液灌流装置治疗安眠药中毒(1983年获天津市科技成果二等奖);11.建立教学、科研与生产三结合的教学新体系(1989年获国家教委优秀教学成果奖)。
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何炳林, Jiegen Chu, Zhi Yuan, Xiaohang Liu, Qiang Wu, Huaifeng Mi, Binglin He
Clinica Chimica Acta 311(2001)95-107,-0001,():
-1年11月30日
Artif Intern Organs 18-1972.98x, there has been great interest in the separation and identification of the role of UMM. However, few of the compounds isolated from UMM fractions were demonstrated to play an important role in humans. Thus, the separation and identification of the real UMM is essential for UMM research. Methods: Urine and serum samples from uremic patients and healthy subjects were separated by gel permeation chromatography. Two presumed UMM fractions, A and B, were obtained from uremic sera and urine, normal urine, but not normal sera. Fraction A was further isolated by anion exchange chromatography and a series of sub-peaks were obtained. The sub-fraction A-3 obtained in the second step was desalted on a Sephadex G-15 column, and characterized by IR, UV and matrix-assisted laser desorptionr ionization time-of-flight mass spectrometry-MALDI-TOF-MS.. Further separation of sub-fraction A-3 was performed by high performance liquid chromatography-HPLC.. Results: By gel permeation chromatography, two UMM peaks-A and B. were detected at 206 nm in normal urine, uremic sera, but they were barely noticed in the profile of normal sera. In contrast, the absorption at 206 nm of fractions A and B from uremic serum and urine were smaller than that of fractions A and B from normal urine. Fractions A from different origins were resolved into eight to nine sub-peaks at 230 nm by anion exchange chromatography. One of these sub-peaks, A-3, was detected in uremic serum and normal urine, but is undetectable in uremic urine. After desalting, sub-fraction A-3 was separated into two parts designated as A-3-I and A-3-II. MALDITOF-MS revealed that fraction A-3-I and A-3-II from two origins were identical, respectively-fraction A-3-I contained three components with MW 839.69, 1007.94 and 2015.16 and fraction A-3-II consisted of another three components with MW 873.69, 1106.67 and 1680.28. Six middle molecular compounds in sub-fraction A-3 were thoroughly resolved by HPLC. Conclusion: Our results demonstrated that the UMM sub-fraction A-3 contains the real UMM in the MW range of 800-2015 Da. By multi-step chromatographic isolation, six real middle molecular compounds were purified and character-
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何炳林, Xue-Mei Zhai, Wei Wang, * Zhen-Peng Ma, Xiao-Jing Wen, Fei Yuan, Xiong-Feng Tang, and Bing-Lin He
Macromolecules 2005, 38, 1717-1722,-0001,():
-1年11月30日
Crystalline macromolecules form folded-chain lamellar and metastable crystals. Annealing at a temperature below melting point results in a thickening of the metastable crystals to construct more stable ones. Such a process was visualized by AFM equipped with a hot stage in monolayers of poly- (ethylene oxide) lamellar crystals on a silicon wafer surface. Our observations show that the monolayers can be thickened in a stepwise manner during stepwise heating to temperatures below the melting point. Our analyses show the thickening process and mechanism as follows: At the first step a small portion of the lamellar crystals have the capability to be spontaneously thickened into a thicker one at a certain temperature range, giving rise to a difference in lamellar thickness. In the following step the thinner lamellae are forced to melt, and then the melted molecules enter an amorphous phase in which they are transported toward the thicker lamellae and finally recrystallize in the thicker ones. This inductive mechanism is analogous to the evaporation-condensation mechanism.
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何炳林, Linqi Shi, * Wangqing Zhang, Fenfang Yin, Yingli An, Huan Wang, Lichao Gao and Binglin He
New. J. Chem., 2004, 28, 1038-1042,-0001,():
-1年11月30日
Amphiphilic block copolymer polystyrene-block-polyacrylic acid (PS-b-PAA) self-assembles into spherical core-shell micelles in the block-selective solvent water with the PS block as the core and the PAA block as the shell. When adding 1-propanol to the micellar solution and then casting the micellar solution at suitable temperatures, the spherical core-shell micelles are assembled into flower-like aggregates on substrates such as glass, formvar film or silicon. The size of the flower-like aggregates ranges from 2 2mm2 to 15 15mm2. Casting temperature, substrate type and character of the block copolymers and additive can all affect the assembly of PS-b-PAA micelles. The assembly of micelles is similar to the fractal aggregation of inorganic particles and a possible reason is discussed.
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何炳林, Lichao Gao, † Linqi Shi, *, † Yingli An, † Wangqing Zhang, † Xudong Shen, † Shiyi Guo, ‡ and Binglin He †
JUNE 8, 2004 VOLUME 20, NUMBER 12,-0001,():
-1年11月30日
In this letter we describe a simple physical method for the ordered aggregation of scattered single spherical polystyrene-b-poly(acrylic acid) (PS-b-PAA) micelles. First, narrow dispersed spindlelike aggregates, about 60 nm in diameter and 1.5 Im in length, are obtained from the aggregation of single spherical PS-b-PAA micelles at 0℃ on a glass slide. Then, the yielding spindlelike units can further aggregate into long-ranged, close-packed, flowerlike arrays after a given amount of freeze-thaw cycles. The formation of the interesting arrays is ascribed to the templated aggregation of micelles on the water polycrystal at the freezing point.
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何炳林, Wangqing Zhang, Linqi Shi, * Yingli An, Kai Wu, Lichao Gao, Zhen Liu, Rujiang Ma, Qingbin Meng, Chenjing Zhao, and Binglin He
Macromolecules 2004, 37, 2924-2929,-0001,():
-1年11月30日
The adsorption of poly(4-vinyl pyridine) (P4VP) unimers into spherical core-shell micelles self-assembled by polystyrene-block-poly(acrylic acid) (PS200-b-PAA78) in ethanol is studied by a combination of static light scattering (SLS) and dynamic light scattering (DLS). P4VP unimers with a coil size of ca. 7.9 nm can be first absorbed into the PS-b-PAA spherical core-shell micelles with a ydrodynamic diameter of 79.9 nm and then penetrate into the shell of the micelles to form hydrogen-bonded micelleunimers complexes in ethanol. During the adsorption, the hydrodynamic diameter and gyration radius of the micelle-unimers complexes decrease first and then stay almost unchanged when P4VP solution in ethanol is added into the PS-b-PAA micelle solution. It is also found that the structure of the micelleunimers complexes remains spherical but becomes smaller and denser than that of the PS-b-PAA micelles after absorption of P4VP unimers.
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何炳林, Xu Tongwen a, *, Yang Weihua a, He Binglin b
Chemical Engineering Science 56(2001)5343-5350,-0001,():
-1年11月30日
In this paper, both the percolation theory andthe three-phase model (TPM) are employedto study the ionic transport behavior in sulfonated poly(phenylene oxide) (SPPO) series membranes. The conductive fraction was obtained from TPM, which had consideredcontributions of both the functional group andthe neutral electrolytes impregnatedin the polymer gel. The critical thresholdat which the ions can be transportedthrough the membrane or the membrane transit from insulator to a conductor, was calculated by the experimental data of membrane conductivities with di8erent sulfonation degrees. The results showed that the thresholdchangedslightly from 0.14 to 0.19 when the concentration ranges from 0.01 to 0.1. Since the thresholdis mainly determinedby the active group zone andd istribution, so a geometrically average value 0.16 is reasonably assumedhere. This assumption coincides with the TPM which states that inter-gel fraction is not relatedwith external concentration but relatedwith the membrane properties. This experimental threshold is a little greater than the ideal value of 0.15 for a complete random system, suggesting that these ion cluster phases containing functional groups are not randomly dispersed in a practical SPPO membrane. If contribution of inter-gel is not considered, we will get a slightly larger value 0.18 as described in the previous paper. Therefore, a combination of TPM andpercolation theory can bring us more precise information on ionic transport in SPPO matrices.
Poly (, phenylene oxide), polymer, Ionic transfer, Ion exchange membrane, Percolation threshold, Three-phase model, Conductivity
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何炳林, Husheng Yan, Shunzi Li, Xuejun Sun, Huaifeng Mi, Binglin He
H. Yan et al./FEBS Letters 554(2003)100-104,-0001,():
-1年11月30日
Residues 1-9 of M(12^26) (GLPALISWIKRKRQQ-NH2), the C-terminal 15-residue segment of melittin, were substituted individually to change the hydropathicities in these positions. Antimicrobial and hemolytic activities of these peptides were determined. The results showed increased antimicrobial activities with increased hydrophobicities at almost all the positions studied. The e
Melittin, Antimicrobial peptide, Hemolysis, Hydrophobic, Amphipathic
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何炳林, Xiaohong Wang a, Jianbiao Ma a, b, *, Yinong Wang a, Binglin He a
Biomaterials 23(2002)4167-4176,-0001,():
-1年11月30日
Biocompatibility of two calcium phosphate cements (CPCs), reinforced with phosphorylated chitosan (P-chitosan), was investigated in rabbits in present study. The two CPCs are monocalcium phosphate monohydrate (MPCM) with calcium oxide (CaO) in 1 m phosphate buffer (i.e. MCPM/CaO/1 m phosphate buffer cement, CPC-I) and dicalcium phosphate dihydrate (DCPD) with calcium hydroxide [Ca(OH)2] in 1m Na2HPO4 solution (i.e. DCPD/Ca(OH)2/1 m Na2HPO4 cement, CPC-II). Different amount of P-chitosan was added to the liquid phase before the power phase was mixed with the liquid phase. The MCPM/CaO/1 m phosphate buffer/P-chitosan cements (P-CPC-I) with neutral pH were filled into the holey defects of rabbit tibias. While the DCPD/Ca(OH)2/1 m Na2HPO4/P-chitosan cements (P-CPC-II) shaped as prehardened cylinders were implanted into rabbit radial defects. After operation, the two serial groups and CPC-II controls were observed for 1, 4, 12 and 22 weeks, respectively. Histological and histomorphological studies proved that P-chitosan containing cements are biocompatible, bioabsorbable and osteoinductive. The biodegradation rate has a negative relationship with the P-chitosan content. Progressive substitution took place at the interface of implants and host bones. No adverse effects were found in tissues around the bone defects. Thus, they could be used as bone substitutes in clinic
Skeletal repair, Phosphorylated chitosans, Calcium phosphate cements, Bone substitutes, Osseoinduction
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何炳林, Guodong Liu, Haofeng Yu, Husheng Yan*, Zuoqing Shi, Binglin He
Journal of Chromatography A, 952(2002)71-78,-0001,():
-1年11月30日
Cystine and tyrosine were used as model sorbates to illustrate the design of sorbents with high sorption selectivity using two types of weak interactions that act synergistically. When two types of weak interactions are the driving forces in a sorption and they act synergistically, the second interaction would be effectively intramolecular. The entropy lost for the second interaction should be lower than that for the same interaction that occurs alone, and thus a significant enhancement of sorption should result.We designed an N-acetyl aminomethyl polystyrene resin (N-acetyl HC-D309), which was expected to sorb tyrosine through hydrophobic interaction and hydrogen bonding but not cystine. The chromatographic results for tyrosine and cystine indicate that the separation efficiencies on the N-acetyl HC-D309 column are higher than those on a styrene–divinylbenzene copolymer column, on which sorption should be driven by hydrophobic interaction only, and on an acrylamide-N,N9-methylene bisacrylamide copolymer column, on which sorption should be driven by hydrogen bonding only. Tyrosine as well as cystine had no retention at all on the acrylamide-N,N9-methylene bisacrylamide copolymer column, indicating the hydrogen bonding had little contribution to the sorption when it acted alone. The above results further indicate that hydrophobic interaction and hydrogen bonding contributed to the sorption of tyrosine on N-acetyl HC-D309 and they also acted synergistically. One of the conclusions of this paper is that some weak interactions which contribute little to the sorption when they act alone may contribute to the sorption when they act synergistically with other interactions.
Synergetic effect, Polymeric sorbents, Hydrogen bonding, rophobic interaction, Molecular recognition
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何炳林, Rongfu Shi a, Mancai Xu a b, Zuoqing Shi a, *, Yunge Fan a, Xianzhi Guo a, Yongning Liu a, hunhong Wang a, Binglin He a
Reactive & Functional Polymers 50(2002)107-116,-0001,():
-1年11月30日
Polymeric adsorbents with both functions of adsorption and decolorization were synthesized by introducing quaternary 1 ammonium groups (e.g.-N+(CH3)3 groups) into conventional resinic adsorbent used to adsorb stevia glycosides in (CH3)3 production. The relation between the adsorption capacity of the bifunctional adsorbents for stevia glycosides and the structure of adsorbents, and that between the decolorization efficiency and the structure were investigated. The results revealed that the adsorption capacity for stevia glycosides decreased somewhat as the increase of the content of quaternary ammonium groups in the adsorbent, while the decolorization efficiency increased. Adsorbents containing about 0.6-0.81mmol/g of (e.g.-N+(CH3)3 groups) showed both high adsorption capacity and high decolorization efficiency, and showed 3 3 adsorptive selectivity for the small-sized components of stevia glycosides. Mechanism of adsorption and decolorization was also studied, and revealed that adsorption of stevia glycosides was based on hydrophobic interactions, but decolorization was 1 based on both ion exchange and hydrophobic interactions. Introduction of (-N+(CH3)3 groups) into polymeric adsorbent also (CH3)3 changed the adsorption selectivity for various stevia glycosides, and thus the bifunctional adsorbent could be used to prepare stevia glycosides with high content of rebaudioside A.
Polymeric adsorbent, Stevia glycosides, Adsorption, Decolorization, Hydrophobic interactions, Ion exchange
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