赵素萍
主要从事以鼻咽癌为主的头颈肿瘤的研究
个性化签名
- 姓名:赵素萍
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学术头衔:
博士生导师
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学科领域:
耳鼻咽喉科学
- 研究兴趣:主要从事以鼻咽癌为主的头颈肿瘤的研究
赵素萍,教授,女,1950年3月出生,湖南双峰人,中国共产党员,医学博士,教授,博士生导师。现任中南大学湘雅医院耳鼻咽喉科主任。享受政府特殊津贴。现任中华医学会湖南省分会耳鼻咽喉科专业委员会副主委、湖南省医学会第十一届理事会理事,湖南省女医生协会常务理事。主要从事以鼻咽癌为主的头颈肿瘤的研究。先后承担及完成各级课题9项,其中CMB1项、国家自然科学基金2项,“863”计划1项(参与),“十五”攻关课题1项(参与),国家科技部1项(参与),省自然科学基金1项,省科委1项,省卫生厅1项。获得省厅级科技成果进步奖8项,其中省科技进步二等奖6项,三等奖2项。在国际国内各级杂志发表论文109篇,以第一作者发表论文30多篇,其中国外杂志发表2篇,中华医学杂志(英文版)3篇。主编全国高等医药院校配套教材《耳鼻咽喉科学习题集》,副主编著作一本,参编全国高等医药院校教材《耳鼻咽喉科学》五版等书籍共8本,担任《中国耳鼻因咽喉颅底外科杂志》副主编及《中华耳鼻咽喉科杂志》《中国耳鼻咽喉-头颈外科杂志》、《临床耳鼻咽喉科杂志》、《中国眼-耳鼻咽喉科杂志》、《现代医学杂志》等7本杂志的编委。
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赵素萍, 周新富
中华耳鼻咽喉科杂志,2001,36 (4):275~277,-0001,():
-1年11月30日
目的 探讨神经生长因子(nerve growth factor, NGF)在变应性鼻炎发病中的作用。方法 建立SD大鼠变应性鼻炎的模型,利用酶联免疫吸附测定(enzyme-linked immunosorbent assay, ELISA)法测定实验性变应性鼻炎鼻粘膜组织中的神经生长因子的含量。结果 实验性变应性鼻炎鼻粘膜的神经生长因子含量(-x±s,下同; n=9)为(6.65±0.42) ng/g湿重,对照组(n=6)为(3.51±0.29)ng/g湿重,二者相比差异有显著性(P<0.001)。结论 神经生长因子可能通过调节神经肽的表达和释放和/或者通过活化免疫细胞(如肥大细胞)而在变应性鼻炎的发生中起重要作用。
神经生长因子, 鼻炎,, 变应性,, 常年性, 模型,, 生物学, 酶联免疫吸附测定
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【期刊论文】TrKA和p75神经营养因子受体在嗅神经母细胞瘤的表达
赵素萍
湖南医科大学学报,2003,,28(1):50~52,-0001,():
-1年11月30日
目的:探讨TrKA和p75神经营养因子受体在嗅神经母细胞瘤的表达及其临床意义。方法:应用免疫组化和双荧光标记法对10例鼻腔嗅神经母细胞瘤及5例正常鼻腔嗅黏膜及5例鼻咽癌组织进行TrKA和p75神经营养因子受体检测。结果:免疫组化检测发现10例鼻腔嗅神经母细胞瘤TrKA和p75蛋白均呈阳性表达,5例正常鼻腔嗅黏膜及5例鼻咽癌组织均为阴性表达;双荧光标记显示所有肿瘤组织中TrKA和p75蛋白均在同一细胞表达。结论:TrKA和p75神经营养因子受体的过度表达可能与嗅神经母细胞瘤的发生和发展有关;TrKA和p75神经营养因子受体检测可作为嗅神经母细胞瘤的一种辅助诊断方法。
嗅神经母细胞瘤, 免疫组织化学, 双荧光标记
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【期刊论文】CHANGES OF NUCLEAR DNA CONTENT IN DIFFERENT TYPES OF NASOPHARYNGEAL EPITHELIUM
赵素萍, Zhao Su-ping, Tao Zheng-de, Xiao Jian-yun, Xiao Ping-tian and Peng Yong-yan
Chinese Medical Journal, 107(5).371-374, 1994.,-0001,():
-1年11月30日
The unclear DNA content was measured with flow cytometry (FCM) in 167 specimens of normal nasopharyngeal epithelium (NE), adjacent tissue to carcinoma (ATC) and nasopharyngeal carcinoma (NPC). All 20 patients with NE showed diploid, whereas 38 (38%) of 101 patients with NPC, 7 (58%) of 12 patients with recurrent NPC, 6 (30%) of 20 pa-tients with ATC and 2 (33%) of 6 patients with NE, positive to EBVCA-IgA test, showed nondiploid. In addition, cellular proliferation index (PI) of diploid NPC and diploid ATC, though differred nonsignificantly, was significantly increased as compared with that of NE (P<0.01). The rate of cervical metastasis in nondiploid NPC was significantly higher than that in diploid NPC (P<0.025).
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赵素萍, Zhao Suping, Tao Zhengde, Xiao Jianyun and Peng Yongyan
Chinese Medical Journal, 108(5):377-382, 1995.,-0001,():
-1年11月30日
Cellular morphology and nuclear DNA content were meas-ured with point-counting technique and flow cytometry (FCM) respectively in normal nasopharyngeai epithelium (NE), tissue adjacent to carcinoma (ATC) and nasopharyngeal carcinoma (NPC). The results showed that all 20 patients with NE show-ed diploid, whereas 38 (38%) of 101 patients with NPC, 7 (58%) of 12 patients with recurrent NPC, 6 (30%) of 20 pa-tients with ATC and 2 (33%) of 6 patients with NE positive to EBVCA-IgA test showed nondiploid. A total of 19 morphometric parameters of the cell were measured and calcu-lated. The results showed that with malignant transformation of NE, most of the cellular morphometric parameters gradually increased in numerical values while no marked difference was shown between normal NE and simple hyperplasia or metaplasia in terms of cytomorphometric characteristics. Most of the parameters in dysplasia changed significantly as com-pared with those normal NE, simple hyperplasia or mctaplasia and NPC groups. Cytomorphometric analysis seems to give strong support to the concept that dysplasia is among the transitional stages of disease process between normal NE and NPC. Our results show that morphometric analysis and FCM may offer valuable and objective criteria in the early diagnosis of NPC and premalignant disease.
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