游劲松
(1)不对称催化与合成技术、有机金属化学及合成方法学;(2)生物功能分子模拟研究:模拟酶和仿生功能体系在不对称合成中的应用;(3)生物相容和生物降解性肽-糖杂化大分子的合成以及在基因和药物传输人工载体、其它生物医学材料领域的应用
个性化签名
- 姓名:游劲松
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学术头衔:
博士生导师, 教育部“新世纪优秀人才支持计划”入选者
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学科领域:
有机化学
- 研究兴趣:(1)不对称催化与合成技术、有机金属化学及合成方法学;(2)生物功能分子模拟研究:模拟酶和仿生功能体系在不对称合成中的应用;(3)生物相容和生物降解性肽-糖杂化大分子的合成以及在基因和药物传输人工载体、其它生物医学材料领域的应用
游劲松教授,出生于1968年,博士,博士生导师。1989年毕业于重庆大学应用化学系,1998年毕业于四川大学化学系,获得理学博士学位,此后,分别在台湾中兴大学、德国Rostock有机催化研究所、美国依阿华州立大学(Iowa State University)、美国加州大学尔湾分校(University of California at Irvine)进行学习和研究工作,2003年被聘为四川大学特聘教授。主要从事的研究领域包括:(1)、不对称催化与合成技术、有机金属化学及合成方法学;(2)、生物功能分子模拟研究:模拟酶和仿生功能体系在不对称合成中的应用;(3)、生物相容和生物降解性肽-糖杂化大分子的合成以及在基因和药物传输人工载体、其它生物医学材料领域的应用。迄今已发表研究论文60 篇,多篇论文发表在Angew. Chem. Int. Ed., Chem. Eur. J., Chem. Commun. , J. Org. Chem. , Organometallics 等世界著名刊物。此外,参编著作1部,获得两项国际授权专利(Ger. Offen. DE10235916A和PCT Int. Appl. WO2004011414 A1 )。游劲松教授2004年入选教育部新世纪优秀人才计划,2005年获得四川省杰出青年基金。
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成果数
12
游劲松, Jingsong You and John G. Verkade*
J. Org. Chem., Vol. 68, No.21, 2003,-0001,():
-1年11月30日
A new catalyst system for the synthesis of R-aryl-substituted nitriles is reported. The bicyclic triaminophosphine P(i-BuNCH2CH2) 3N (1b) serves as an efficient and versatile ligand for the palladium-catalyzed direct α-arylation of nitriles with aryl bromides. Using ligand 1b, ethyl cyanoacetate and primary as well as secondary nitriles are efficiently coupled with a wide variety of aryl bromides possessing electron-rich, electron-poor, electron-neutral, and sterically hindered groups.
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【期刊论文】The Inhibiting Influence of Aromatic Solvents on the Activity of Asymmetric Hydrogenations**
游劲松, Detlef Heller, * Hans-Joachim Drexler, Anke Spannenberg, Barbara Heller, Jingsong You, and Wolfgang Baumann*
Angew. Chem. Int. Ed. 2002, 41, No.5,-0001,():
-1年11月30日
Complexes of ruthenium, iridium, and especially rhodium have been used in the homogeneously catalyzed asymmetric hydrogenation of prochiral olefins, ketones, and imines. [1] Hydrogenations are usually carried out in simple alcohols, but aromatic solvents, water, or alcohol/aromatic solvent mixtures can also be used. It has been reported that aromatic solvents such as benzene can inhibit asymmetric hydrogena-phosphatase efficiently and selectively, thereby displaying the fundamental requirements for turnover-based enzyme inactivation.
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【期刊论文】Preparation and Asymmetric Hydrogenation of β-Aryl-Substituted b-Acylaminoacrylates**
游劲松, Jingsong You, Hans-Joachim Drexler, Songlin Zhang, Christine Fischer, and Detlef Heller*
Angew. Chem. Int. Ed. 2003, 42, No.8,-0001,():
-1年11月30日
The synthetic opportunities for the preparation of optically active b-amino acids are based mainly on stoichiometric reactions with chiral auxiliaries and to a significantly lesser
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【期刊论文】A General Method for the Direct a-Arylation of Nitriles with Aryl Chlorides**
游劲松, Jingsong You and John G. Verkade*
Angew. Chem. Int. Ed. 2003, 42, 5051-5053,-0001,():
-1年11月30日
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【期刊论文】A Highly Active and Selective Catalyst System for the Baylis-Hillman Reaction**
游劲松, Jingsong You, Juhua Xu, and John G. Verkade*
Angew. Chem. Int. Ed. 2003, 42, 5054-5056,-0001,():
-1年11月30日
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游劲松, Jing-Song You, a Xiao-Qi Yu, a Guo-Lin Zhang, b Qing-Xiang Xiang, a Jing-Bo Lana and Ru-Gang Xie*a
Chem. Commun., 2001, 1816-1817,-0001,():
-1年11月30日
Novel chiral imidazole cyclophane receptors were synthesized by highly selective N-alkylation of the imidazolyl 1Nposition of the bridged histidine diester 2 with the dibromide in the presence of NaH; these receptors exhibit good chiral recognition toward the enantiomers of L-and D-amino acid derivatives (up to KD/KL=3.52, △△G0=-23.11 kJ mol-1) in CHCl3 at 25.0℃.
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游劲松, Jing-Song You, † Han-Mou Gau*a and Michael C. K. Choi*b
Chem. Commun., 2000, 1963-1964,-0001,():
-1年11月30日
The asymmetric addition of Me3SiCN to aldehydes catalyzed by titanium (IV) complexes of N-sulfonylated derivatives of b-amino alcohols gave excellent ee's up to 96% ee.
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游劲松, Jing-Bo Lan, Li Chen, Xiao-Qi Yu, * Jing-Song You and Ru-Gang Xie*
Chem. Commun., 2004, 188-189,-0001,():
-1年11月30日
In the presence of a catalytic amount of a simple copper salt, the coupling of imidazole with arylboronic acids was performed in methanol to give corresponding N-arylimidazoles in almost quantitative yields; this coupling reaction could also be performed in aqueous solutions to give N-arylimidazoles in excellent yields.
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游劲松, Jing-Song You, † Sheng-Hsiang Hsieh and Han-Mou Gau*
Chem. Commun., 2001, 1546-1547,-0001,():
-1年11月30日
The asymmetric methylation, ethylation and allylation of aldehydes using trialkylaluminium reagents catalyzed by titanium (IV) complexes of N-sulfonylated amino alcohols gave excellent enantioselectivities of up to 99% ee.
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游劲松, Detlef Heller, * [a] Hans-Joachim Drexler, [a] Jingsong You, [a] Wolfgang Baumann, [a] Karlheinz Drauz, [b] Hans-Peter Krimmer, [b] and Armin B
Chem. Eur. J. 2002, 8, No.22,-0001,():
-1年11月30日
The enantioselective hydrogenation of E- and Z-methyl 3-acetamidobutenoate, key intermediates in the synthesis of a pharmaceutically important chiral β-amino acid, with RhI catalysts in MeOH as solvent has been investigated in detail. As chiral ligands, Et-DuPHOS, Me4-BASPHOS, DIPAMP, DIOP, HO-DIOP and Et-Ferro-TANE have been employed. T he particular role of oxyfunctionalization in some diphosphine catalysts is addressed in relation to the E/Z geometry of the substrate and the dependency of the ee on the H2 pressure.Kinetic investigations with [Rh (diphosphane) (MeOH) 2]-BF4, taking into consideration the special nature of the precatalyst {[Rh-(cod) 2] BF4/ligand versus [Rh (cod) ligand)] BF4}, NMR spectroscopic measurements and the H2 pressure dependence of the observed enantioselectivity provide evidence that the reaction proceeds via an "unsaturated route" mechanism. T his mechanism correlates to catalytic features found in the past for the hydrogenation of related unsaturated-amino acid precursors. T he influence of the temperature was similarly investigated.A nonlinear dependency of the enantiomeric ratio as a function of the reciprocal of the temperature has been found. The correlation between temperature and H2 pressure and their effects on the enantioselectivity is discussed. In general, the highest enantioselectivities for the hydrogenation of both isomeric substrates can be achieved at room temperature and below, whereas the fastest conversion takes place at 30-50℃.
β-amino acid • sasymmetric synthesis • hydrogenation • phosphanes • rhodium
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