黄建梅
中药化学成分研究和中药质量分析
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- 姓名:黄建梅
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学术头衔:
博士生导师
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学科领域:
中药学
- 研究兴趣:中药化学成分研究和中药质量分析
黄建梅,女,1970年生,北京中医药大学中药学院分析化学教研室副教授,中国药学会高级会员,中华中医药学会中药分析分会委员。1997年毕业于北京中医药大学,获博士学位;随后在北京中医药大学中药学院工作;1999-2001年,赴日本德岛文理大学药学部做博士后研究。一直从事中药化学成分研究和中药质量分析工作,先后承担多项国家级、部级和校级课题的研究工作。发表论文20余篇,其中有12篇为SCI收载文章。“八角茴香类和地枫皮类中草药的系统研究”获1999年度国家中医药管理局中医药基础研究奖一等奖。
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成果数
11
【期刊论文】SESQUITERPENE LACTONES FROM THE PERICARP OF ILLICIUM DUNNIANUM
黄建梅, HUANG JIANMEI, * WANG JIALIN and YANG CHUNSHU
Phytochemistry, Vol.46, No.4, pp.777-780, 1997,-0001,():
-1年11月30日
Two new sesquiterpene lactones, 1, 4-epoxy-6-deoxypseudoanisatin and neodunnianin, were isolated from the pericarp of Illicium dunnianum, together with a sesquiterpene, phaseic acid. Their structures were elucidated on the basis of spectroscopic and chemical data. The structure of neodunnianin was confirmed by X-ray diffraction analysis.
Illicium dunnianum, Illiciaceae, pericarp, sesquiterpene lactone, 1,, 4-epoxy-6-deoxypseudoanisatin, neodunnianin.,
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【期刊论文】seco-Prezizaane-type sesquiterpenes from Illicium merrillianum
黄建梅, Jian-Mei Huang a, Chun-Shu Yang b, Hironobu Takahashi a, Yoshiyasu Fukuyama a, *
J.-M. Huang et al./Phytochemistry 55(2000)883-886,-0001,():
-1年11月30日
Four seco-prezizaane sesquiterpene lactones, 14-O-n-butyrylfloridanolide, 3, 4-dehydro-oridanolide, 3, 6-dideoxy-10-hydroxy-pseudoanisatin, and 2-O-n-butyrylpseudomajucin were isolated from the pericarps of Illicium merrillianum. Their structures were determined by spectroscopic methods.
Illicium merrillianum, Illiciaceae, Pericarps, seco-Prezizaane, Sesquiterpene, Floridanolide, Pseudoanisatin, Pseudomajucin
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黄建梅, Jian-Mei Huang, a Chun-Shu Yang, b Masami Tanaka a and Yoshiyasu Fukuyama a, *
J.-M. Huang et al./Tetrahedron 57(2001)4691-4698,-0001,():
-1年11月30日
Two new anislactone-type sesquiterpenes, merrilactones B (1) and C (2) were isolated from the pericarps of Illicium merrillianum along with anislactones A (4) and B (5). Their structures were elucidated by spectroscopic methods and chemical transformation and the structure of merrilactone C was established by X-ray crystallographic analysis of its methyl derivative. Merrilactone A (3), a unique anislactone-type sesquiterpene showing neurite outgrowth promoting activity, was effectively synthesized from anislactone B.
Illicium, sesquiterpene, structure, synthesis, anislactone, merrilactone.,
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黄建梅, 黄建梅*, 刘慧, 杨春澍, 叶纪沟, 薛云
中草药,2000,31(1):54~58,-0001,():
-1年11月30日
八角科植物70%的种分布于我国西南部至东部,仅八角茴香Illicium uerum的果实和地枫皮I. difengpi树皮被《中国药典》1995年版收载,其它多为民间用药。因八角科植物果实形态多相似,含较强毒性成分,为保证用药安全,本文描述了16种八角果实形态特征,并列有检索表,为八角科植物果实鉴别提供依据。
八角科, 果实, 形态鉴别
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黄建梅, Jian-mei Huang, † Ritsuko Yokoyama, † Chun-shu Yang, ‡ and Yoshiyasu Fukuyama*, †
J. Nat. Prod. 2001, 64, 428-431,-0001,():
-1年11月30日
An extract of the pericarps of Illicium merrillianum has yielded four new sesquiterpenes: 3Rhydroxycycloparvifloralone (1), 1, 2-dehydrocycloparvifloralone (2), (11) 7, 14-ortholactone-3R-hydroxyfloridanolide (3), and 11-O-debenzoyltashironin (4) along with cycloparvifloralone (5), merrillianone (6), and tashironin (7). The structures of 1-4 were determined on the basis of spectroscopic analyses. 11-O-Debenzoyltashironin (4) showed neurotrophic activity in primary culture of rat cortical neurons at 0.1-10μM. However, cycloparvifloralone-type sesquiterpenes (1, 2, 5, and 6) and tashironin (7) had no neurotrophic activity at these concentrations.
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【期刊论文】Seven Novel seco-Prezizaane-Type Sesquiterpenes from the Pericarps of Illicium merrillianum
黄建梅, Jian-Mei HUANG, a Chun-Shu YANG, a Ren ZHAO, b Hironobu TAKAHASHI, c and Yoshiyasu FUKUYAMA*, c
,-0001,():
-1年11月30日
Seven new seco-prezizaane-type sesquiterpenes were isolated from the methanol extract of the pericarps of Illicium merrillianum. Their structures were elucidated as 3-deoxypseudoanisatin (1), 2 β-hydroxy-3, 6-dedioxypseudoanisatin (2), 8 α-hydroxy-10-deoxycyclomerrillianolide (3), 10 β-hydroxypseudoanisatin (4), 10 β-hydroxycyclopseudoanisatin (5), 1, 6-dihydroxy-3-deoxyminwanensin (6), and 8-deoxymerrilliortholactone (7) by analyses of their spectroscopic data and chemical transformation. Compounds 4 and 5 as well as 6 and 7 coexist as a keto/acetal equilibrated mixture in methanol solution.
Illicium,, Illicium merrillianum,, seco-prezizaane-type sesquiterpene
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黄建梅, Jian-Mei HUANG, a Kousuke NAKADE, a Mamiko KONDO, a Chun-Shu YANG, b and Yoshiyasu FUKUYAMA*, a
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-1年11月30日
In the study of bioactive substances in Illicium plants, the methanol extract of I. merrillianum showed brine shrimp lethality test (BST) activity at 200μg/ml. Bioassay-guided fractionation of the BST active fractions resulted in the isolation of 4-O-methyleudesm-11-en-4α-ol, eudesmol-11-en-4α-ol and (-)-hinokinin as potent BST active compounds. On the other hand, four new highly oxygenated seco-prezizaane-type sesquiterpenes, merrilliortholactone (1), 2 α-hydroxycycloparvifloralone (2), 2 α-hydroxycycloparviflorolide (3), and 2 α-hydroxyanisatin (4) were isolated from the BST-inactive polar fractions. The structures of new compounds were elucidated by extensive analyses of spectral data. Furthermore, the absolute configuration of 3 was established by the modified Mosher's method. Compounds 1-4 showed neither BST activity at 100mg/ml nor neurite outgrowth-promoting activity.
Illicium merrillianum, seco-prezizaane-type sesquiterpene, brine shrimp lethality
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黄建梅, Jian-Mei Huang, a Chun-Shu Yang, a Mamiko Kondo, b Kosuke Nakade, b Hironobu Takahashi, b Shigeru Takaoka b and Yoshiyasu Fukuyama b, *
J.-M. Huang et al./Tetrahedron 58(2002)6937-6941,-0001,():
-1年11月30日
Novel sesquiterpene lactones, (6R)-pseudomajucin (1) and merrillianin (3), have been isolated from the pericarps of Illicium merrillianum, and their structures have been elucidated on the basis of the spectral data. A methanol solution of (6R)-pseudomajucin coexisted with (6R)-pseudomajucinone (2) in a keto/acetal equilibrium, whereas the crystals solely consisted of a keto-type 2, the structure of which was established by X-ray crystallographic analysis. The absolute stereochemistry of 1 was determined by the X-ray crystallographic analysis of its 7-O-methyl-3-O-p-bromophenylcarbamate. Merrillianin (3) is a unique seco-prezizaane-type sesquiterpene with an unprecedented dilactone moiety, which may be biosynthesized from pseudomajucin (4) or (6R)-pseudomajucin (1) by oxidative cleavage of the C-6/C-7 bond.
Illicium merrillianum, seco-prezizaane, pseudomajucin, merrillianin.,
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【期刊论文】Merrilactone A, a novel neurotrophic sesquiterpene dilactone from Illicium merrillianum
黄建梅, Jian-mei Huang, a Ritsuko Yokoyama, a Chun-shu Yang b and Yoshiyasu Fukuyama a, *
,-0001,():
-1年11月30日
Merrilactone A, isolated from the pericarps of Illicium merrillianum, shows an intriguing neurotrophic activity in the cultures of fetal rat cortical neurons. Its structure has been elucidated to be a unique ses-quiterpene bearing two γ-lactones and an oxetane ring by extensive analyses of spectral data and then confirmed by X-ray crystallographic analysis. Further, the absolute configuration has been established by the modified Mosher's method.
Illicium merrillianum, sesquiterpene lactone, merrilactone A, structure elucidation, neurotrophic activity.,
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【期刊论文】Seco-Prezizaane-Type Sesquiterpenes and an Abietane-Type Diterpene from Illicium minwanense
黄建梅, Ritsuko Yokoyama, † Jian-Mei Huang, ‡ Atsuko Hosoda, † Kozue Kino, † Chun-Shu Yang, ‡ and Yoshiyasu Fukuyama*, †
J. Nat. Prod. 2003, 66, 799-803,-0001,():
-1年11月30日
A methanol extract of the pericarps of Illicium minwanense afforded seven new seco-prezizaane-type sesquiterpenes (2-8) and a new abietane-type diterpene (9), together with six previously known compounds (1 and 10-14). The structures of the new compounds, (1S*)-and (1R*)-minwanenone (2 and 3), 1Rhydroxy-6-deoxypseudoanisatin (4), (2S)-hydroxy-6-deoxypseudoanisatin (5), 3-oxopseudoanisatin (6), (3S*, 6R*)-4, 7-epoxy-6-deoxypseudoanisatin (7), 7-O-methylpseudomajucin (8), and (+)-8, 11, 13, 15-abietatetraene (9), were elucidated by spectroscopic data analysis and chemical transformations. The absolute configurations of 1 and 5 were established by X-ray crystallographic analysis of their p-bromobenzoyl derivatives.
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