冯庆玲
从事天然生物材料结构性能研究,矿化机理研究,纳米人工骨,组织工程人工肝等方面的研究。
个性化签名
- 姓名:冯庆玲
- 目前身份:
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学术头衔:
博士生导师,
- 职称:-
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学科领域:
材料科学
- 研究兴趣:从事天然生物材料结构性能研究,矿化机理研究,纳米人工骨,组织工程人工肝等方面的研究。
冯庆玲,女,教授,博士生导师,1990年获得柏林大博士学位,1992年至今在清华大学材料系从事各种生物材料的研究。期间曾两次赴德国柏林工业大学和韩国培才大学进行生物材料合作研究。作为课题负责人承担国家863项目和国家自然科学基金项目。发表论文百余篇,其中SCI收录50余篇,申请国家发明专利15,项,出版一部专著《生物材料学》。有关生物矿化机理的研究获教育部科技进步二等奖1项。现任中国复合材料学会理事,《复合材料》,《生物骨科材料与临床研究》,《韩国材料学会》杂志编委。长期从事天然生物材料结构性能研究,矿化机理研究,纳米人工骨,组织工程人工肝等方面的研究。
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成果数
17
【期刊论文】Skeletal repair in rabbits with calcium phosphate cements incorporated phosphorylated chitin
冯庆玲, Xiaohong Wang a, b, *, Jianbiao Ma b, Qingling Feng a, Fuzhai Cui a
Biomaterials 23 (2002) 4591-4600,-0001,():
-1年11月30日
The effects of phosphorylated chitin (P-chitin) on the tissue responses to two kinds of calcium phosphate cements (CPCs) were investigated using experimental rabbits. One of them consisting of monocalcium phosphate monohydrate, calcium oxide, 1 m phosphate buffer (pH: 7.4) and different amounts of P-chitin (CPC-I or P-CPC-I) with relatively neutral initial pH was filled as paste into tibial defects of the rabbits for 1, 4, 12 and 22 weeks. The other kind of cement made from dicacium phosphate dihydrate/calcium hydroxide/1m Na2HPO4/different amounts of P-chitin (CPC-II or P-CPC-II) with relatively higher initial pH was implanted as prehardened cylinders into the radial defects of the rabbits for the same periods. Pure CPC-I and CPC-II were used as controls. Histological and histomorphological studies were performed on thin un-decalcified and decalcified sections. Three different bone formation types in the resorption lacuna of the P-CPCs were found during this study. The biodegradation rate of the P-CPCs had a negative relationship with the P-chitin content. Most of the low P-chitin-containing samples were bioabsorbed in 16 weeks, while the high P-chitin-containing samples disappeared in 22 weeks. The newly formed bone was identified with back scattered scanning electron microscopy and X-ray energy-dispersive spectrometry. The results show that with P-chitin component in a certain range, the P-CPCs are biocompatible, bioabsorbable and osteoinductive and could be used as promising candidates of bone repair materials.
Calcium phosphate cements, Phosphorylated chitin, Skeletal repair, Bone substitutes, Osteoinductive
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冯庆玲, Q.L. Feng a, *, G. Pu a, Y. Pei a, F.Z. Cui a, H.D. Li a, T.N. Kim b
Journal of Crystal Growth 216 (2000) 459-465,-0001,():
-1年11月30日
The function of biomacromolecules during biomineralization was studied by simulating the nucleation and growth of calcium carbonates in vitro. The synthetic crystals nucleated and grew on different organic (EDTA-insoluble proteins) and inorganic (silicon) matrices with EDTA-soluble proteins extracted from mollusk shells. The polymorph and morphology of the crystals were investigated using scanning electron microscope (SEM), X-ray diffraction (XRD) and transmission electron microscope (TEM) with selected area electron diffraction (SAED). It is found that different proteins have specialties to induce different crystals with special morphologies. The soluble proteins extracted from nacre can induce aragonite and the one from prism can induce calcite grown with a preferred orientation of[104]. The crystals induced by the same soluble proteins have the same polymorph and morphology. The insoluble proteins insoluence the density of nucleation sites as well as the sizes and quantities of the crystals.
Aragonite, Biomacromolecules, Biomineralization, Calcite
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【期刊论文】Controlled crystal growth of calcium phosphate on titanium surface by NaOH-treatment
冯庆玲, Q.L. Feng a, *, H. Wang a, F.Z. Cuia, T.N. Kim b
Journal of Crystal Growth 200 (1999) 550-557,-0001,():
-1年11月30日
A simple supersaturated calcification solution (SCS) was used to deposit calcium phosphate (Ca-P) on the surface of NaOH-treated titanium (NaOH-Ti), in order to study the corresponding deposition mechanism of calcium phosphate (Ca-P). No Ca-P coating from SCS was found on titanium without NaOH-treatment, while NaOH-Ti possessed the capability to induce a Ca-P coating on the titanium surface. Octacalcium phosphate (OCP) crystals were first grown on an NaOH-Ti surface, followed by hydroxyapatite (HA) with a[001] preferential orientation on OCP. It is found that two factors controlled the growth of Ca-P crystals on NaOH-Ti from SCS. First, the surface morphology of NaOH-Ti characterized with crevices seems to be beneficial for inducing a Ca-P coating from SCS; second, the basic hydroxyl, Ti-OH, radical has increased in NaOH-Ti with the increase of treating time and concentration, which facilitate the nucleation of Ca-P crystals.
Calcium phosphate, Deposition mechanism, NaOH-treatment, Titanium
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【期刊论文】Ag-substituted hydroxyapatite coatings with both antimicrobial effects and biocompatibility
冯庆玲, Q. L. FENG, F. Z. CUI, T. N. KIM, J. W. KIM
JOURNAL OF MATERIALS SCIENCE LETTERS 18 (1999) 559-561,-0001,():
-1年11月30日
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【期刊论文】Crystal orientation, toughening mechanisms and a mimic of nacre
冯庆玲, Q.L. Feng*, F.Z. Cui, G. Pu, R.Z. Wang, H.D. Li
Materials Science and Engineering C 11 2000 19-25,-0001,():
-1年11月30日
Based on the investigations of crystal structure of nacre using SEM, TEM and XRD, it is proposed that there exists a domain structure of crystal orientation in the nacre. The orientation domain consists of continuous 3-10 tablets along the direction perpendicular to nacreous plane, and 1-5 tablets in a single lamina. The tablets in a domain are crystallographic identical in three dimensions. From the crack morphologies, it is found that the crack deflection, fibre pull-out and organic matrix bridging are the three main toughening mechanisms acting on nacre. The organic matrix plays an important role in the toughening of this biological composite. The biomimetically synthesized composite made of alumina and kevlar showed significant increase in the fracture energy compared with the single ceramics. The soluble proteins extracted from nacre can induce aragonite and the one from prism can induce calcite grown with the preferred orientation of 104. The insoluble proteins control the nucleation site and thus lead to a finer crystallization of CaCO3.
Nacre, Crystal structure, Toughening mechanisms, Biomimetics, Biomineralization
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【期刊论文】Crystal orientation preference and formation mechanism of nacreous layer in mussel
冯庆玲, W.T. Hou*, Q.L. Feng
Journal of Crystal Growth 258 (2003) 402-408,-0001,():
-1年11月30日
Using a new and simple etching method to investigate the tablets of nacre, it is possible to observe a great deal of tablets in a large range. We found that most tablets have the same formal orientations after citric acid treatment. This phenomenon occurred not only in the same lamina but also along the direction perpendicular to nacreous plane. Based on the additional selected area diffraction patterns of transmission electron microscope, it is proposed that the formal orientations could indicate the crystal orientations of aragonite tablets.Statistical analyze shows that there is a main (type I tablets) and a secondary (type II tablets) preferred orientation with an angle of around 60 between them. Two possible modes of structural correspondence between protein sheets and aragonite lattice are assumed to interpret the orientation preference. On the other hand, the cluster character of type II tablets strongly supports that mineral bridges of the organic matrix have significant function in the crystal growth.At last, the mechanisms of structural correspondence and mineral bridges are combined to explain the formation process of nacreous layer in mussel.
A1., Biomineralization, A1., Crystal orientations, A1., Etching, A3., Mineral bridges, A3., Structural correspondence, B1., Aragonite
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冯庆玲, Q. L. FENG*, H. B. LI, G. PU, D. M. ZHANG, F. Z. CUI, H. D. LI, T. N. KIM
JOURNAL OF MATERIALS SCIENCE 35 (2000) 3337-3340,-0001,():
-1年11月30日
The structure and crystallographic orientation of mineral phase in the oblique prismatic layer of Mytilus edulisshell were studied by SEM, XRD and TEM with selected area electron diffraction (SAED). A crystallographic orientation regulation, i.e. the adjacent 1-5 calcite prisms with the same three-dimensional orientation in the oblique prismatic layer, was found for the first time. It is observed that the calcite prisms in the oblique prismatic layer were grown with their (104) parallel to the shell surface.
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冯庆玲, Q.L. Feng a, *, F.Z. Cui a, H. Wang a, T.N. Kim b, J.O. Kim b
Journal of Crystal Growth 210 (2000) 735-740,-0001,():
-1年11月30日
The present paper demonstrated a biomimetic method to coat calcium phosphate (Ca-P) on the surface of titanium induced by NaOH-treatment from a simple supersaturated hydroxyapatite solution (SHS). The in#uence of pH value and calcium ions concentration on the precipitation process was investigated. It is necessary for the solution to be supersaturated than the critical concentration of octacalcium phosphate (OCP) to get Ca-P coatings on titanium surface. In the precipitating process, it seems that amorphous calcium phosphate (ACP) precipitated first, then OCP, and finally hydroxyapatite (HA). The system was in continuous evolution and the phase transitions occurred in sequence.
Calcium phosphate, NaOH-treatment, Precipitation process, Solution conditions, Titanium
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【期刊论文】A simple biomimetic method for calcium phosphate coating
冯庆玲, F. Li a, Q.L. Feng a*, F.Z. Cui a, H.D. Li a, H. Schubert b
Surface and Coatings Technology 154 (2002) 88–93,-0001,():
-1年11月30日
A biomimetic calcium phosphate coating is expected to enhance the bioactivity and bone inductivity of human implants. This study presents a very simple, highly effective biomimetic method to obtain a calcium phosphate coating on a titanium substrate. Using NaH2PO4, a stable solution was prepared with high calcium and phosphate ion concentrations. This solution turned to a supersaturated calcification solution (SCS) when NaHCO3 was added. The addition of NaHCO3 elevated the pH value of the solution gradually and steadily. A uniform coating approximately 40 mm thick was found on the substrates after 24 h immersion. The compositions of the coatings were adjustable from hydroxyapatite (HA) to HAydicalcium phosphate dihydrate (DCPD). The calcium phosphate deposits were investigated by means of scanning electron microscopy (SEM), X-ray diffraction (XRD) and Fourier transformed infrared (FT-IR) spectroscopy.
Calcium phosphate coating, Biomimetics, Titanium
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冯庆玲, T. N. Kim a, b, Q. L. Feng a, Z. S. Luo a, F. Z. Cuia, *, J. O. Kim b
Surface and Coatings Technology 99 (1998) 20-23,-0001,():
-1年11月30日
Ion-beam assisted deposition (IBAD) was carried out to deposit hydroxyapatite (HAp) on alumina substrate. The amorphous coating layer on alumina substrate is crystallized to the dense HAp after a post. treatment process of annealing at 500℃ for 2 h and immersion in deionized water for 72 h at room temperature. The homogeneous and dense HAp coating is observed by scanning electron microscopy and the thickness of the coating is measured to be about 638 um. The hardness of the coating 1ayer in the as-deposited and post-treated samples is 475 and 508, respectively. The adhesive strength between HAp and α-alumina substrate was measured by a scratch test. The ion-beam sputtered coatings were used as control samples, the adhesion was found to be worse for ion-beam sputtering deposition (IBSD) than for IBAD.
Alumina, Hydroxyapatite coating, Ion-beam assisted deposition
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