申宗侯
糖基转移酶相关的信号转导与基因表达
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- 姓名:申宗侯
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学术头衔:
博士生导师
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学科领域:
生物化学
- 研究兴趣:糖基转移酶相关的信号转导与基因表达
1968年毕业于上海第一医学院医学系,从事医疗工作十年。 1978年回上海医科大学生化系。 1979年赴瑞士巴塞尔大学学习分子生物学。 1982年回武汉大学生化系从事生化分子生物学教研工作,期间于1987-1988,1994年分别赴美国康奈尔大学及奥地利格拉兹大学合作科研。 1996年回上海医科大学生化与分子生物学系,从事教研工作。研究方向为:糖基转移酶相关的信号转导与基因表达。
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申宗侯, Yi Lu, Ying-Ying Xu, Kai-Yi Fan, Zong-Hou Shen*
Biochemical and Biophysical mescal ch Communications 344(2006)221-225,-0001,():
-1年11月30日
a1, 2-Mannosidases key enzymes in N-glycan processing and located both in the endoplasmic reticulmu and golgi, have been targets in the development of anti cancer therapies. Previous studies have shown its involvement in protein degradation. In this study 1-deoxymannojirimycin, a specificinhibitor of a1, 2-mannosidase and generating high mannose type of N-glycan, was treated in human hepatocarcinoma 772I cells and lnduced the endoplasmic reticulum strss. Key moleculars as XBPl and GRP78/Bip were activated and up-regulated, which suggested the UPR pathway was activated. The cleavage of caspase-12, -9 and-3 was also detected, which impli-caled the ER stress was triggered and apoptosis occurred in H7721 cells. The results lndlcare the high Man structure generated by 1-deoxymannojirilnyein may constitute potential novel mechanism fol ER slress and caspase-12 pathway of cell apoptosis.
al,, 2-Mannosidase, 1-Deoxymannojirimycin, Endoplasmic reticulum stress, Apoptosis
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