张镇西
从事的研究方向为生物医学光子学及应用、光生物物理学和医用生物材料及技术等。
个性化签名
- 姓名:张镇西
- 目前身份:
- 担任导师情况:
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学术头衔:
博士生导师
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学科领域:
生物物理学
- 研究兴趣:从事的研究方向为生物医学光子学及应用、光生物物理学和医用生物材料及技术等。
张镇西,教授,博士,博士生导师,1990年博士研究生毕业于西安交通大学,获生物医学工程及仪器博士学位。 1991-1993年在中国科学技术大学进行博士后研究。现任西安交通大学生命科学与技术学院副院长、生物医学工程及生物物理学教授、博士生导师、教育部高等学校生物医学工程专业教学指导委员会委员(2006-2010年)、生物医学光子学教育部网上合作研究中心副主任及学术委员会委员、《激光生物学报》副主任编委、《光电子?激光》、《激光杂志》、《国际生物医学工程杂志》(原《国外医学生物医学工程分册》 )、《世界医疗器械》编委、中国光学学会生物医学与激光医学专业第五届委员会委员、中华医学学会陕西省分会激光医学专业委员会副理事长、中华医学学会激光医学分会第四届全国委员会专业学组基础组副组长、陕西省电子学会生物电子学专业委员会副理事长、西安生命科学与技术学会理事长、西安激光与红外学会副理事长。全国高协组织教材研究与编写委员会委员、全国高协组织教材研究与编写委员会生命科学与工程专业委员会主任委员。“蒋大宗基金”管理委员会主任。曾五次在德国斯图加特大学、放射与环境保护研究所(幕尼黑)、洪堡大学医学院肿瘤医院(柏林)、威廉港应用大学和吕倍克应用大学从事科学研究。目前发表论文百余篇,译著《激光与生物组织的相互作用??原理及应用》、《医学工作者的因特网》、《分子光子学》、《 激光与生物组织的相互作用原理及应用》(第3版)四部。获部科技进步三等奖二项。
目前作为课题负责人承担国家自然科学基金的研究项目有:基于ALA脂类衍生物的光动力疗法对白血病细胞的影响 (60178034)、心脏电活动高分辨光学标测技术的研究 (60378018)、基于激光技术的微粒辅助基因转染新方法研究(60578026);省部级的研究项目有:静止悬浮激光衍射法自动血细胞计数及分类仪器的研究(96C17)、用于骨损伤和缺陷的骨再生材料等(2000C17)。中德合作科研项目(PPP)“基因转染新方法研究-激光照射金纳米颗粒诱导细胞的选择性吸收”中方负责人(2005183025)。从事的研究方向为生物医学光子学及应用、光生物物理学和医用生物材料及技术等。硕士生、博士生课程2门、指导20名硕士研究生和20名博士研究生,其中16人已获硕士学位、8人已经获博士学位。还指导 过13名德国留学生和1名在读博士研究生。
承担研究项目(课题负责人):医学光电科学与技术教育部重点实验室资助项目(负责人):1.组织电活动的实时光学标测技术(JYG0502) CSC-DAAD联合资助重点实验室项目(负责人):1.2006年中德合作科研项目(PPP)基因转染新方法研究??激光照射金纳米颗粒诱导细胞的选择性吸收(2005183025)
教育部聘请外国专家重点项目(负责人):1.光学标测技术(2004229);2.激光诱导的基因转染新方法研究(20050360887);3.基于超短脉冲激光 微束的细胞微手术(20060509)
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21
张镇西, 张宝琴, 肖谧(综述), 张镇西(审校)
国外医学儿科学分册,2004,3l(4):209~211,-0001,():
-1年11月30日
近年来,光动力治疗的研究已经取得了令人瞩目的成绩。光动力治疗诱导白血病细胞发生凋亡主要从光敏剂的定位、应用条件、对线粒体和细胞膜的损伤、引起细胞色素c的释放和半胱氨酸蛋白酶(caspase)。3的活化等方面发挥作用。在诸多因素引起凋亡的同时,Bd.2发挥着抗凋亡的作用。除此之外,离子通道的变化也参与凋亡的发生。
光化学疗法, 白血病, 细胞凋亡
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张镇西, Niu Jinlong a, b, ∗, Zhang Zhenxi a, Jiang Dazonga
Materials Chemistry and Physics 78 (2002) 308-312,-0001,():
-1年11月30日
The formation of calcium potassium sodium orthophosphate (Ca2KNa(PO4)2) from sodium dihydrogen phosphate dihydrate (NaH2PO4 2H2O), potassium dihydrogen phosphate (KH2PO4) and calcium carbonate (CaCO3) was investigated using differential thermal analysis (DTA), thermal gravimetric analysis (TGA) and powder X-ray diffraction (XRD). DTA showed five distinct thermal events attributed to dehydration of NaH2PO4 2H2O, dehydration of NaH2PO4 and KH2PO4, the transition of amorphous calcium sodium phosphate to-CaNaPO4, the decomposition of CaCO3 to CaO, and the crystallization of Ca2KNa(PO4)2. TGA showed 5.6% weight loss between 70 and 170℃ due to the dehydration of NaH2PO4 2H2O to NaH2PO4; the 7.3% weight loss between 170 and 280℃ is due to the dehydration of NaH2PO4 and KH2PO4; a continuous weight loss over 280-760℃ due to the reaction of melted alkali metal phosphates with CaCO3 and an approximate 8% weight loss between 670 and 840℃ due to the calcination of residual CaCO3. XRD analysis, as a function of temperature, supported the evolution of these events and phases, showed the formation of other intermediates: -CaKPO4 and calcium potassium pyrophosphate (CaK2P2O7). The proposed mechanism of the reaction to Ca2KNa(PO4)2 involves the formation and consumption of these intermediates: acid alkali metal pyrophosphate, metaphosphate, CaK2P2O7 and β-CaNaPO4.
Resorbable bioceramic, Calcium alkali phosphate, Thermochemical synthesis
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【期刊论文】Investigation of Phase Evolution During the Thermochemical Synthesis of Tricalcium Phosphate
张镇西, Niu Jinlong, , Zhang Zhenxi, and Jiang Dazong
Journal of Materials Synthesis and Processing, Vol. 9, No. 5, September 2001,-0001,():
-1年11月30日
The formation of tricalcium phosphate (TCP) from dicalcium phosphate and calcium carbonate was investigated using differential thermal analysis (DTA), thermogravimetric analysis (TGA), and powder X-ray diffraction (XRD). DTA showed three distinct thermal events attributed to dehydration of dicalcium phosphate dihydrate (brushite, DCPD) to dicalcium phosphate anhydrous (monetite, DCPA), the formation of beta-calcium pyrophosphate (b-Ca2P2O7), and the calcination of calcium carbonate. TGA showed three weight losses corresponding to the three thermal events, respectively. XRD analysis showed that b-TCP formed, beginning at about 900°C, by the reaction of b-Ca2P2O7 with CaO and b-TCP changed to a-TCP above 1200℃. Further examination of the formation of TCP from calcium hydroxide (Ca(OH)2) and DCPA showed that b-TCP would form only after the decomposition of Ca(OH)2 to CaO and from the reaction of CaO with b-Ca2P2O7 at a fairly low temperature of 800℃. In addition, by naturally cooling a-TCP, formed at 1300℃ within the heating furnace, to room temperature, it was difficult to obtain a pure phase of b-TCP. The proposed mechanism of the reaction to form TCP may include the dehydration of brushite to monetite, dehydration of monetite to beta-calcium pyrophosphate, decomposition of calcium carbonate, the formation of b-TCP, and phase transition.
Tricalcium phosphate, ceramic, thermochemical synthesis
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张镇西, 姚翠萍, 李政, 张镇西**
光学学报,2005,25(12):1664~1669,-0001,():
-1年11月30日
激光微手术的精度通常受到热作用或者热机械效应间接损伤的限制。把激光脉宽调整到与吸收颗粒的热弛豫时间一致可以避免热副作用,可对所选细胞产生选择性处理。这里胶体金与牛肠硷性磷酸脂酶(Alkaline phosphatase,AP)结合物作为分析强吸收颗粒附近的蛋白质变性的模型系统,利用皮秒和纳秒激光对结合体进行照射,在一定的条件下可以使蛋白质失活,并可以使细胞膜的通透性提高。通过计算可知,采用脉宽为皮秒或者纳秒级的激光照射纳米吸收物(胶体金)时,颗粒很容易被加热到几百开,而且热效应仅限于几十纳米的空间范围内。利用纳米吸收颗粒进行激光微手术的方法,在蛋白质失活的情况下对其机理进行了分析。
医用光学与生物技术, 激光微手术, 选择性损伤, 高精度
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【期刊论文】Mechanisms of the acute ischemia-induced arrhythmogenesis-A simulation study
张镇西, Hong Zhang a, b, Zhen-xi Zhang a, *, Lin Yang c, Yin-bin Jin a, Yi-zhuo Huang a
Mathematical Biosciences 203 (2006) 1-18,-0001,():
-1年11月30日
The underlying ionic mechanisms of ischemic-induced arrhythmia were studied by the computer simulation method. To approximate the real situation, ischemic cells were simulated by considering the three major component conditions of acute ischemia (elevated extracellular K+ concentration, acidosis and anoxia) at the level of ionic currents and ionic concentrations, and a round ischemic zone was introduced into a homogeneous healthy sheet to avoid sharp angle of the ischemic tissue. The constructed models were solved using the operator splitting and adaptive time step methods, and the perturbation finite difference (PFD) scheme was first used to integrate the partial differential equations (PDEs) in the model. The numerical experiments showed that the action potential durations (APDs) of ischemic cells did not exhibited rate adaptation characteristic, resulting in flattening of the APD restitution curve. With reduction of sodium channel availability and long recovery of excitability, refractory period of the ischemic tissue was significantly prolonged, and could no longer be considered as same as APD. Slope of the conduction velocity (CV) restitution curve increased both in normal and ischemic region when pacing cycle length (PCL) was short, and refractory period dispersion increased with shortening of PCL as well. Therefore, dynamic changes of CV and dispersion of refractory period rather than APD were suggested to be the fundamental mechanisms of arrhythmia in regional ischemic myocardium.
Computer simulations, Myocardial ischemia, Reentry, Ventricular arrhythmias
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张镇西, Zhang Sujuan, Zhang Zhenxi, Zhang Baoqin
ACAD J XJ TU 2005, 17 (2): 135-140,-0001,():
-1年11月30日
Objective To optimize experimental parameters for the photosensitization of 52aminolevulinic acid (ALA) in promyelocytic leukemia cell HL60 and compare them with normal human peripheral blood mononuclear cell (PBMC). Methods ALA incubation time, wavelength applied to irradiate, concentration of ALA incubated, irradiation fluence may modulate the effect of 52aminolevulinic acid based Photodynamic Therapy (ALA2PDT). The high2pressure mercury lamps of 400W served as light source, the interference f ilter of 410 nm, 432 nm, 545 nm, 577 nm were used to select the specif ic wavelength. Fluorescence microscope was used to detect the fluorescence intensity and location of protoporphyrin IX (PpIX) endogenously produced by ALA. MTT assay was used to measure the survival of cell. Flow cytometry with ANNEXIN V FITC kit (contains annexin V FITC, binding buffer and PI) was used to detect the mode of cell death. Re sults ①1 mmol/L ALA incubated 1×105/mL HL60 cell line for 4 hours, the maximum fluorescence of ALA induced PpIX was detected in cytomembrane. ② Irradiated with 410 nm for 14. 4 J/cm2 can result in the minimum survivability of HL60 cell. ③ The main mode of HL60 cell death caused by ALA2PDT is necrosis. Conclusion ALAfor 1 mmol/L, 4 hours for dark incubation time, 410 nmfor irradiation wavelength, 14.4 J/cm2 for irradiation fluence were the optimal parameters to selectively eliminate promyelocytic leukemia cell HL60 by ALA based PDT. The photosensitization of ALA based PDT caused the necrosis of HL60 cell, so it could be used for inactivation of certain leukemia cells.
52aminolevulinic acid (, ALA), , photodynamic therapy (, PDT), , leukemia cell HL60, optimal parameter
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【期刊论文】Preparation, structure and solubility of Ca2KNa(PO4)2
张镇西, NIU JINLONG∗, ZHANG ZHENXI, JIANG DAZONG, YANG SHENGHONG, MA GUANGLAI, WANG KEGUANG
JOURNAL OF MATERIALS SCIENCE 36 (2001) 3805-3808,-0001,():
-1年11月30日
Materials based on calcium alkali orthophosphate using for filling bone defects have been fabricated by means of solid state reaction method. The starting materials were selected from chemical reagents: CaHPO4•2H2O, CaCO3, Na2CO3, K2CO3 and H3PO4(85%). After these materials were mixed stoichiometrically and dried at 200◦C for 2 hours, the mixture was sintered in air at high temperature for 2 hours. The samples were characterized by X-ray diffraction. The results showed that the new materials contained only one crystal phase: Ca2KNa(PO4)2, whether the sintering temperature was 1350 degrees C or higher if the material was designed as Ca2KNa(PO4)2. Furthermore, the solubility was tested and it revealed that these materials containing Ca2KNa(PO4)2 had higher solubility than α-TCP.
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张镇西, Hong Wu, , Zhenxi Zhang, Daocheng Wu, Hongping Zhao, Kaitao Yu, Zhenqing Hou
,-0001,():
-1年11月30日
Gelatin microspheres (GMs) containing Pingyangmycin hydrochloride were prepared for the interventional embolization by a double-phase emulsified thermal gelation method using oxidized dextran (ox-dex) as the cross-linking agent. The average diameter of the microspheres was 82 m with 74% ranging from 50-200 m. Drug content and the characteristics of drug release in vitro and in vivo were evaluated using UV-spectroscopy and HPLC, respectively. The prepared microspheres showed a rather high percentage of encapsulation ranging from 85 to 88% and drug content at 7.2%. The results of in vitro experiments showed that about 65.5% of the total amount of the encapsulated drug was released after 6 h at 37
pingyangmycin, extran, gelatin microspheres, sustained release, embolization
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【期刊论文】Study on Antibacterial Property of TiO2 Nanoparticles
张镇西, Xiong Yuying, , Zheng Pinqi, Xiong Jianwen, Xioa Hua, Zhang Zhenxi
,-0001,():
-1年11月30日
The TiO2 nanoparticles are prepared by chemistry precipitating method and sol-gel method. The resulting materials are characterized by XRD. The ultraviolet catalyze on antibacterial property of TiO2 have been validated through experiment.
TiO2 nanoparticles, antibacterial property.,
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