张兴栋
从事超硬材料研究
个性化签名
- 姓名:张兴栋
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学术头衔:
博士生导师
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学科领域:
材料合成与加工工艺
- 研究兴趣:从事超硬材料研究
张兴栋,男,1938年生,四川大学生物材料工程研究中心教授, 1960年毕业于四川大学固体物理专业,1983年开始从事生物医学材料研究。国家生物医学材料工程技术研究中心奠基人、名誉主任,中国生物材料委员会副主席、秘书长,第九次世界生物材料大会(2012年)主席,国际生物陶瓷学会主席,国际生物材料科学与工程学会联合会(IUSBSE)国际委员会委员,国际组织工程与再生医学学会亚太委员会理事,中国材料研究学会常务理事,中国复合材料学会理事,日本国家材料研究所生物材料中心顾问,全国医疗器械生物学评价技术标准化委员会副主任。生物材料研究方面:发表论文340余篇,编著10部,获国家和部、省级一、二等奖九项。获IUSBSE授予的终生荣誉称号“国际生物材料科学与工程Fellow”,印度生物材料与人工器官学会终生会员及2004年国际“C. P. Sharma”奖。1973年开始从事超硬材料研究,研制出立方氮化硼单晶、多聚烧结体及磨具和刀具,人造多晶金刚石及超深井硬地层钻头、高速拉丝用人造聚晶金刚石等,出席全国科学大会。
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235
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成果数
4
【期刊论文】Tissue responses of calcium phosphate cement: a study in dogs
张兴栋, Huipin Yuana, b, c, *, Yubao Lia, JD de Bruijnb, K. de Grootb, Xingdong Zhanga
Biomaterials 21(2000)1283-1290,-0001,():
-1年11月30日
The in vivo properties of a new kind of calcium phosphate cement were investigated in this study. Calcium phosphate cement was implanted as paste into femoral bone and dorsal muscle of dogs for 3 and 6 months, and as prehardened form into thigh muscles of dogs for 1, 2 and 6 months. Histology was performed on thin un-decalcibed sections. No foreign body reaction, no incammation and no necrosis were found both in bony site and in muscles. There was no connective tissue layer between the cement and bone when cement paste was implanted in the bone. A creeping substitution of cement by bone, in which osteoclast-like cells resorbed the cement as if the cement is a part of bone and new bone was formed directly on the resorption line of calcium phosphate cement, was found. Bone formation was found histomorphologically in pores and deep rugged surface of cement samples (both paste and prehardened form) implanted in muscles of dogs. The induced bone was also identied with backscattered scanning electron microscopy (BSE) and by energy-dispersive X-ray micro-analysis (EDX). The results suggest that the calcium phosphate cement used in this study is biocompatible, resorbable in a manner of creeping substitution, osteoconductive and osteoinductive. It seems that an ideal bone substitute can be developed by using this type of calcium phosphate cement.
Calcium phosphate cement, Tissue responses, Osteoconduction, Osteoinduction, Ideal bone substitute
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张兴栋, HUIPIN YUAN, , J. D. DE BRUIJN, YUBAO LI, JIANQING FENG, ZONGJIAN YANG, K. DE GROOT, XINGDONG ZHANG
JOURNAL OF MATERIALS SCIENCE: MATERIALS IN MEDICINE 12(2001)7-13,-0001,():
-1年11月30日
Two kinds of tri-calcium phosphate ceramics Ca/P=1.50)α-TCP and β-TCP, which has the same macrostructure and microstructure, but different phase composition, were implanted in dorsal muscles of dogs. The samples were retrieved at 30, 45 and 150 days, respectively, after implantation, and were analyzed histologically. There were critically different tissue responses between a-TCP ceramic and β-TCP ceramic. Higher cell populations were observed inside the pores of β-TCP than those of α-TCP, bone tissue was found in β-TCP at 45 and 150 days, but no bone formation could be detected in any α-TCP implants in this study. On the other hand, the bone tissue in β-TCP seemed to degenerate at 150 days. The results indicate that porous β-TCP can induce bone formation in soft tissues of dogs; while the rapid dissolution of the ceramic and the higher local Ca2+, PO3-4 concentration due to the rapid dissolution of α-TCP may resist bone formation in α-TCP and the less rapid dissolution of β-TCP may be detrimental to already formed bone in β-TCP.
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【期刊论文】A preliminary study on osteoinduction of two kinds of calcium phosphate ceramics
张兴栋, Huipin Yuana, b, *, Kenji Kurashinac, Joost D. de Bruijnb, d, Yubao Lia, K. de Grootb, Xingdong Zhanga
Biomaterials 20(1999)1799-1806,-0001,():
-1年11月30日
With respect to the e!ect of material factors on calcium phosphate biomaterial-induced osteogenesis, the osteoinductive property of two kinds of porous hydroxyapatite ceramics, which were made by di!erent producers, was investigated in dorsal muscles of dogs. One hydroxyapatite ceramic (S-HA), macroporous implants with rough pore walls containing abundant micropores, was made by Sichuan Union University (Chengdu, China); the other hydroxyapatite ceramic (J-HA), porous implants with smooth macropore walls composed of regularly aligned crystal grains, was provided by Mitsubishi Ceramic Int. (Japan). Di!erent tissue response was detected histologically and microradiographically after the ceramic samples had been implanted in dorsal muscles of dogs for 3 and 6 months. Bone formation was found in S-HA at 3 months, which increased at 6 months. In contrast, no bone formation was detected in J-HA at both 3 and 6 months. These results indicate that with the special architecture, calcium phosphate ceramic can induce bone formation in soft tissue. As both materials were very similar in their chemical and crystallographic structures, but varied in their microstructures, the latter seem to be an important factor a!ecting the osteoinductive capacity of calcium phosphate ceramics. These data suggest that, by controlling the preparation of calcium phosphate ceramic, bone substitutes with intrinsic osteoinductive property can be developed from calcium phosphates.
Calcium phosphate biomaterials, Micropores, Biomaterials with intrinsic osteoinductive property, Material dependent
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【期刊论文】A preliminary study of the mechanism of the apatite nucleation on chemically treated titanium
张兴栋, BANGCHENG YANG, JIE WENG, XUDONG LI, XINGDONG ZHANG
,-0001,():
-1年11月30日
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