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钱志勇
博士研究生 教授 博士生导师
四川大学 生物治疗国家重点实验室
主要研究方向为生物医用高分子材料、药剂学、纳米生物技术等。
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- 姓名：钱志勇
- 目前身份：在职研究人员
- 担任导师情况：博士生导师
- 学位：
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学术头衔：
博士生导师
- 职称：高级-教授
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学科领域：
药剂学
- 研究兴趣：主要研究方向为生物医用高分子材料、药剂学、纳米生物技术等。
钱志勇，四川大学华西医院生物治疗国家重点实验室教授，博士生导师。
2000年获四川大学材料学专业硕士学位，2003年获中科院成都有机化学研究所有机化学专业博士学位，2003年9月起在四川大学师从涂铭旌院士从事纳米生物材料的博士后研究工作，2005年9月起任生物治疗国家重点实验室教授。
主要研究方向包括纳米生物材料、生物医用高分子材料、新型药物传递系统等。为科技部“十一五”863重点项目召集人、国家重点研发计划课题负责人。以第一完成人身份获得2019年度高等学校科学研究优秀成果奖（科学技术）自然科学奖一等奖，以第一完成人身份获得成都市自然科学奖，获得四川省青年科技奖（个人奖）、获得2019年度“药明康德生命化学研究奖学者奖”（个人奖）。2015-2019连续五年入选Elsevier中国高被引学者榜单（生物医学工程领域）。以第一作者或通讯/共同通讯作者身份在Adv Funct Mater, ACS Nano, Adv Sci, Nano Lett, Chem Soc Review, Nano Research, Acta Pharm Sinica B, Chinese Chemical Letters等国内外知名学术期刊发表SCI收录论文100余篇，其中10篇论文曾入选ESI高被引论文，h-index是56。获得16项授权的中国发明专利，有两组专利技术与企业达成转让协议，并于2018年获得两项药物临床试验批件。
兼任中国医药生物技术协会纳米生物技术分会主任委员，四川省科技青年联合会副主席，J Biomed Nanotechnology期刊主编，Materials Express主编，Signal Transduction、Targeted Therapy副主编，Chinese Chemical Letters期刊副主编，J Biological Engineering期刊副主编，Acta Pharm Sinica B、Human Gene Therapy等多个国际学术期刊的编委。
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782
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成果数
11
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2006-10-31
钱志勇， GuoTao Chao， ， HongXin Deng， †， Qiong Huang， WenJuan Jia， WanXia Huang， YingChun Gu， HePing Tan， LinYu Fan， CaiBing Liu， AnLiang Huang， Ke Lei， ChangYang Gong， MingJing Tu and ZhiYong Qian， *
Journal of Polymer Research (2006) 13: 349-355，-0001，（）：
-1年11月30日
In this article, a pH sensitive semi-interpenetrating network (SIPN) hydrogel based on methacrylic acid, BSA, and PEG was prepared by UV initiated free radical polymerization. The swelling behavior and pH sensitivity of these hydrogels were studied in detail. With the increase in pH of the aqueous solution from 1.7 to 9.23, the swelling ratio of these hydrogels increased accordingly. The effect of BSA and crosslinker (BIS) content on the swelling behavior was more complicated, and the results were shown in the text.
hydrogel， macromolecular drug delivery， responsive delivery systems， water absorption
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2006-10-31
钱志勇， Yan Wang， CaiBing Liu， LinYu Fan， Yong Sheng， Jian Mao， GuoTao Chao， Jun Li， MingJing Tu， ZhiYong Qian， *
Polymer Bulletin 53, 147-154 (2005)，-0001，（）：
-1年11月30日
Biodegradable PBT/PEG copolymers were synthesized by macromolecular transesterification method, and were characterized by 1H-NMR and DSC. Alkaline degradation behavior was studied too. Indirubin loaded microspheres were prepared by O/W solvent evaporation method.
multiblock copolymer， PBT/， PEG， poly(， ether ester)， s， microspheres
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2006-10-31
钱志勇， ZhiYong Qian， Sai Li， Yi He， XiaoBo Liu*
Polymer Degradation and Stability 83 (2004) 93-100，-0001，（）：
-1年11月30日
Hydrolytically degradable PET/PEG block copolymer was synthesized by the macromolecular transesterification method from PET and PEG. Non-isothermal crystallization behavior of the copolymers was investigated by differential scanning calorimetry (DSC). Water absorption and in vitro degradation behaviour of these copolymers were studied in detail. When hydrophilic PEG was incorporated into the PET chain, water absorption increased. With the increase in PEG concentration, the degradation rate increased accordingly. PEG molecular weight has different effects on PET/PEG copolymers' degradation rate.
Block copolymer， PET/， PEG， Thermal property， Hydrolytic degradation， Poly(， ether-ester)， s
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2006-10-31
钱志勇， ZhiYong Qian a， *， Sai Li b， Yi He b， Xiao Bo Liu b
Polymer Degradation and Stability 84 (2004) 41-47，-0001，（）：
-1年11月30日
A new kind of aliphatic polyetheresteramide copolymers (PEEAs) based on E-caprolactone, 11-aminoundecanoic acid, and poly(ethylene glycol) (PEG) were synthesized by melt polycondensation. The thermal and hydrolytic egradation behaviour of these copolymers was studied using FTIR, 1H-NMR, and TGA. PEG content, thickness of the test sample, and pH of degradation medium have great effect on degradation rate. The degradation rate increased with PEG content and pH, but decreased with thickness of the test sample.
Polyetheresteramide， Degradable polymer， Thermal degradation， Hydrolytic degradation， TG
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2006-10-31
【期刊论文】Preparation of biodegradable polyesteramide microspheres
钱志勇， Zhiyong Qian， Sai Li， Yi He， Hailian Zhang， Xiaobo Liu
Colloid Polym Sci (2004) 282: 1083-1088，-0001，（）：
-1年11月30日
Biodegradable polyesteramide copolymer P(CL/AU) based on -caprolactone and 11-aminoundecanoic acid was synthesized by the melt polycondensation method. Polyesteramide (PEA) microspheres were prepared by a simple O/W emulsion solvent evaporation method. The effects of variations in preparation parameters (such as emulsifier concentration, polymer concentration, polymer solution adding rate, stirring rate, and whether vacuum was applied) were studied in detail. The obtained microsphere morphologies were observed using an optical microscope and via scanning electron microscopy (SEM). The particle size distribution was determined using a Malvern laser particle sizer. When the PEA microspheres were incubated in PBS saline, the particle size increased at first, and then decreased after a longer time period; the theory that this behavior was due to degradation of the microspheres was confirmed by SEM.
Polyesteramide， Microspheres， Solvent evaporation method， Surface morphology
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2006-10-31
钱志勇， Qian Zhiyong， Li Sai， Zhang Hailian， Liu Xiaobo
Colloid Polym Sci (2003) 281: 869-875，-0001，（）：
-1年11月30日
A new type of biodegrad-able polyesteramide P(LA/AU) based on lactic acid and aminoun-decanoic acid was synthesized by the meh polycondensation method. The copolymers obtained were charac-terized by FTIR. 1H-NMR, DSC, and XRD. The in vitro degradation behavior of the copolymers was studied using weighing. 1H-NMR. FT1R, DSC. and SEM. With the increase in aminonndecanoic acid units, the mehing temperature and crystallinity increased, but the water absorption and degradation rate decreased accordingly. During degradation in vitro, the ester moiety decreased due to ester cleav-age along the macromolecular main chain. As degradation proceeded. the mehing temperature and crystallinity increased at first, then started to decrease because the crystalline phase was destroyed.
Polyesteramide， Biodegradable polymer， Hydrolytic degradation， Aminoundecanoic acid， Surface morphology
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2006-10-31
钱志勇， Zhiyong Qian， Sai Li， Yi He， Cao Li， Xiaobo Liu*
Polymer Degradation and Stability 81 (2003) 279-286，-0001，（）：
-1年11月30日
A new kind of polyesteramide copolymer based on e-caprolactone and 11-aminoundecanoic acid has been synthesized by melt polycondensation. The copolymers were characterized by FTIR, 1H-NMR, DSC, and WAXD. With the increase in aminoundecanoic acid content, the melting temperature, heat of fusion, and Td,50% increased accordingly. The thermal degradation of the P(CL/AU)x/y copolymers was studied using FTIR, and TG During thermal degradation, the ester bond decomposes at lower temperature, then the amide bond decomposes at higher temperature.
Polyesteramide， Biodegradable polymer， Crystallinity， Thermal degradation， Nylon 11
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2006-10-31
钱志勇， CaiBing Liu a， ZhiYong Qian a， *， YingChun Gu b， LinYu Fan c， Jun Li d， GuoTao Chao a， WenJuan Jia a， MingJing Tu a
Materials Letters 60 (2006) 31-38，-0001，（）：
-1年11月30日
In this paper, biodegradable aliphatic copolyesters were synthesized from q-caprolactone, adipic acid, and 1,6-hexanediol by meltpolycondensation method. The chemical structure, and thermal properties of these copolymers were studied in detail. The water absorption behavior and hydrolytic degradation behavior of this copolyester were also studied. This aliphatic copolyester prepolymer would be used to prepare the biodegradable poly(ester urethane), which might have potential application in biomedical field.
Biodegradable copolymer， Poly(， ester urethane)， ， Aliphatic polyester， Thermal property， In vitro degradation
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2006-10-31
钱志勇， CaiBing Liu， ， YingChun Gu， ZhiYong Qian， LinYu Fan， Jun Li， GuoTao Chao， MingJing Tu， WenJuan Jia
，-0001，（）：
-1年11月30日
In this article, a new kind of biodegradable polyetheresteramide-based polyurethane (PEEA-U) copolymers were prepared by the melt polycondensation method from -caprolactone, 6-aminocaproic acid, poly(ethylene glycol), and toluene diisocyanate. The water absorption of PEEA-U was affected strongly by the reaction time and the content of chain extender; and the hydrolytic degradation behavior of the copolymers was mainly determined by the reaction time, chain extender content, and the pH value of the degradation medium. Also, DSC, 1H-NMR, and inherent viscosity were used to characterize the degradation behavior of the copolymers.
biodegradable polymer， polyetheresteramide copolymer， polyurethane， degradation
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2006-10-31
钱志勇， Zhiyong Qian， Yi He， Yaobang Zou， Sai Li， Xiaobo Liu*
Polymer Degradation and Stability 83 (2004) 127-132，-0001，（）：
-1年11月30日
Degradable polyesteramide fibres were processed by melt-spinning. Tensile properties of as-spun and hot-drawn fibres were also investigated. After drawing, the overall crystallinity and the melting temperature of the copolymer increased. As a result, the tensile strength of the fibre increased, and the elongation at break decreased. The morphology of the surface and fracture cross section were studied by SEM. During alkaline degradation, the tensile strength and the elongation at break both decreased.
Polyesteramide， Degradable polymer， Fibre， Thermal property， Tensile property
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