周向葛
配合物催化剂的合成以及模拟酶催化方面的研究
个性化签名
- 姓名:周向葛
- 目前身份:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
有机化学
- 研究兴趣:配合物催化剂的合成以及模拟酶催化方面的研究
2003年 7月-现在: 四川大学化学学院,教授,博士生导师。 2002年3月–2003年6月 :德国洪堡学者, 德国慕尼黑工业大学(导师:Prof. Wolfgang A. Herrmann) 1999年12月– 2001年2月 :日本学术振兴会(JSPS)博士后, 日本大阪大学基础工学部化学系(导师:Prof. Shun-Ichi Murahashi) 1995年10月 – 1999年11月:博士研究生,香港大学化学系(导师:支志明 院士) 1991年9月 – 1994年7月: 硕士研究生,中国科学院成都有机化学研究所(导师: 蒋耀忠 教授) 1987年9月 – 1991年7月: 本科生, 武汉大学化学系自1991年来主要从事金属有机化学及不对称合成方面的研究。主要工作如下: 在成都有机所攻读硕士期间,在蒋耀忠研究员指导下进行新型钛-手性西佛碱配合物催化醛的不对称硅腈化反应;在香港大学攻读博士期间,在支志明院士指导下,利用联萘衍生物及手性卟啉配体,合成了一系列手性过渡金属催化剂,应用于多种不对称反应;在日本大阪大学(日本学术振兴会)博士后研究期间,在村桥俊一教授指导下,进行过渡金属-酞腈配合物催化氧化饱和碳-氢键的研究;在德国慕尼黑工业大学(德国洪堡基金会)博士后研究期间,在W. A. Herrmann 和 F. E. Kuehn 教授指导下,进行手性高价钼-葡萄糖配合物的合成及其在不对称环氧化反应中的应用研究。申请人总计发表SCI收录文章40余篇,被引用350余次,其中以第一作者发表的一篇(Chem. Commun., 1999, 1789-1790)被引用70余次。2003年底回国后,主要进行配合物催化剂的合成以及模拟酶催化方面的研究。
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554
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成果数
18
周向葛, Xiangge Zhou, Jin Zhao, Ana M. Santos, and Fritz E. Kuhn
Z. Naturforsch. 59b, 1223-1228(2004),-0001,():
-1年11月30日
Three optically active Molybdenum (VI) dioxo complexes with tetrahydro salen and substituted tetrahydro salen derivatives as ligands were synthesized and examined as catalysts for asymmetric epoxidation. Complexes of the type MoO2(L)(Solv) and WO2(L) (L=tridentate, trans-2-aminocyclohexanol derived chiral Schiff base, Solv=alcohol) were prepared and characterized by elemental analysis, NMR and IR spectroscopy. These complexes are applicable as catalysts for olefin epoxidation reactions with tert-butyl hydroperoxide (TBHP) being the oxidizing agent. In case of cis-β-methylstyrene moderate enantiomeric excesses of up to 26% can be reached when the reaction is carried out at 0℃.
Catalysis, Chirality, Epoxidation, Molybdenum, Salen
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【期刊论文】Asymmetric aldol reactions catalyzed by new spiro diamine derivatives
周向葛, Man Jiang, a, Shou-Fei Zhu, b, Yun Yang, Liu-Zhu Gong, c, Xiang-Ge Zhoua, * and Qi-Lin Zhoub, *
Tetrahedron: Asymmetry 17(2006)384-387,-0001,():
-1年11月30日
Two new organocatalysts derived from L-proline and a novel chiral spiro diamine bearing a C2 symmetric backbone, were introduced for an asymmetric aldol reaction in moderate to good asymmetric induction in up to 76% ee and high yields.
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周向葛, Shun-Ichi Murahashi, *, a, b, Xiang-Ge Zhou, Naruyoshi Komiya a
Synlett 2003, No.3, 321-324,-0001,():
-1年11月30日
Chlorinated phthalocyanine iron (II) complex is an excellent catalyst for the oxidation of alkanes and alkenes with molecular oxygen in the presence of acetaldehyde under O2 (1 atm) at room temperature. The catalyst can be easily separated and reused for the next reaction.
oxidations, molecular oxygen, alkanes, iron phthalocyanine catalyst
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周向葛, Xiao-Qi Yu, Jie-Sheng Huang, Xiang-Ge Zhou, and Chi-Ming Che*
Org. Lett., Vol. 2, No.15, 2000,-0001,():
-1年11月30日
Amidation of a variety of hydrocarbons with PhIdNTs catalyzed by ruthenium and manganese meso-tetrakis(pentafluorophenyl)porphyrins 1 and 2 afforded N-substituted amides in up to 92% yields with good to excellent substrate conversions. By employing catalyst 2, exceptionally high turnovers (up to 2600) were achieved, and the amidations can be effected by directly using PhI(OAc)2/NH2R as amidating reagents; in the case of R) COCF3 a direct amination was realized in up to 90% yield.
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周向葛, Zhong-Xia Wang a, *, Hui Zhao a, Zhong-Yuan Zhou b, Xiang-Ge Zhou b
Journal of Organometallic Chemistry 595(2000)158-165,-0001,():
-1年11月30日
The reaction of [{m-h2-C(R1) CHR2}(m-CO)Fe2(CO)6] with (m-S2)Fe2(CO)6 forms (m3-S)2Fe3(CO)9 (1) and:or anionic intermediates [{m-h2-C(R1) CHR2}(m-S){Fe2(CO)6}2(m4-S)] (2) depending on the substituents R1 and R2. The actions of the anionic complexes 2 with alkyl halides, PhN2BF4 and acid chlorides give [m-h2-C(R1) CHR2](m-RS)[Fe2(CO)6]2(m4-S) (R alkyl, Ph or acyl). The structures of (m-h2-CH CHPh](m-CH2 CHCH2S)[Fe2(CO)6]2(m4-S)
Iron, Alkenyl ligand, Bridging-sulfur ligand, Complexes, Synthesis, Structures
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周向葛, Zhong-Xia Wang a, *, Shao-Bin Miao a, Zhong-Yuan Zhou b, Xiang-Ge Zhou b
Journal of Organometallic Chemistry 601(2000)87-92,-0001,():
-1年11月30日
The reaction of [Et3NH] [(m-RE)(m-CO)Fe2(CO)6] (E S, Se) (1) with aryl azides gives bridging triazenido complexes (m-RE)(mp-R1C6H4N3H)Fe2(CO)6 (2-8) (2, RE ButS, R1 H; 3, RE PhS, R1 H; 4, RE ButS, R1 Cl; 5, RE ButS, R1 MeO; 6, RE PhS, R1 MeO; 7, RE PhSe, R1 H; 8, RE PhSe, R1 Cl). These complexes were characterized by elemental analyses and 1H-NMR and IR spectroscopy. The structure of complex 2, established by single-crystal X-ray diffraction analysis, shows that the triazenido ligand binds to two iron centers in a bridging bidentate fashion.
Iron, Selenium, Sulfur, Triazenido ligand, Complex, Structure
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【期刊论文】Nitrene transfer reaction catalyzed by substituted metallophthalocyanines
周向葛, Sheng-Yong Yan a, Yi Wanga, Yuan-Jie Shub, Hui-Hua Liu a, Xiang-Ge Zhoua, c, ∗
Journal of Molecular Catalysis A: Chemical 248(2006)148-151,-0001,():
-1年11月30日
Metallophthalocyanines bearing substituents are found to be efficient catalysts for nitrene transfer reactions. Under optimized reaction conditions, aziridination of alkenes and amidation of C H bonds with PhI=NTs by using 3-trifluromethylphenyoxy-substituted phthalocyanine-iron complex led to the highest yields of 90% and 85% for 4-methylstyrene and 4-ethyltoluene, respectively.
Nitrene transfer, Aziridination, Amidation, Catalytic, Metallophthalocyanine
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【期刊论文】Cyclopropanation of alkenes catalyzed by metallophthalocyanines
周向葛, Hui-Hua Liu a, Yi Wanga, Yuan-Jie Shub, Xiang-Ge Zhoua, c, ∗, Jiang Wu a, Sheng-Yong Yan a
Journal of Molecular Catalysis A: Chemical 246(2006)49-52,-0001,():
-1年11月30日
Metallophthalocyanines bearing substituents especially electron-withdrawing substituents are found to be efficient catalysts for cyclopropanation of alkenes with EDA. The influences of reaction conditions have been studied, leading to the highest yield of 91% for styrene by using fluorosubstituted ruthenium–phthalocyanine complex.
Cyclopropanation, Metallophthalocyanine, Catalyst, Fluoro-substituted
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【期刊论文】Asymmetric epoxidation catalyzed by Cr(Ⅲ)-binaphthyl Schiff base complexes
周向葛, Zheng-Kai Li a, Lei Liang a, Li Yanga, b, Hua Chena, Xiang-Ge Zhoua, c, *
Journal of Molecular Catalysis A: Chemical 235(2005)108-113,-0001,():
-1年11月30日
A series of chromic complexes with binaphthyl Schiff base as ligands are synthesized. Their catalytic abilities in asymmetric epoxidation and the effects of reaction conditions such as temperature, solvent and additive have also been studied, leading to the highest ee of 65% for 4-chlorostyrene; the reaction seems to involve a Cr(V)-oxo active species.
Chromic complex, Binaphthyl Schiff base, Asymmetric epoxidation
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【期刊论文】Ligand chirality-controlled selective formation of mono-and dinuclear copper complexes
周向葛, Xiang-Ge Zhou a, Jie-Sheng Huang a, Zhong-Yuan Zhou b, Kung-Kai Cheung a, Chi-Ming Che a, *
Inorganica Chimica Acta 331(2002)194-198,-0001,():
-1年11月30日
Reaction of copper (II) acetate with the (S)-enantiomer of a tridentate binaphthyl Schiff base ligand, 2-(3,5-dichloro-2-hydroxybenzylideneamino)-2'-hydroxy-1,1'-binaphthyl (H2L), in methanol afforded mononuclear copper (II) complex [CuII(HL)2] ((S,S)-1) in 52% isolated yield. The same reaction gave dinuclear copper (II) complex [CuII2 (L)2] ((R,S)-2) in 73% isolated yield whenracemic-H2L was used instead of (S)-H2L. Both complexes (S,S)-1 and (R,S)-2 were characterized by elemental analysis, massspectrometry, and X-ray crystallography. The present work highlights the functioning of ligand chirality as a 'switch' for selectiveformation of mono-and dinuclear metal complexes.
Chirality, Copper complexes, Schiff base ligands, Crystal structures
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