邓金根
个性化签名
- 姓名:邓金根
- 目前身份:
- 担任导师情况:
- 学位:
-
学术头衔:
博士生导师, 国家杰出青年科学基金获得者
- 职称:-
-
学科领域:
有机化学
- 研究兴趣:
学习和工作简历:
1979年9月-1983年7月 兰州大学化学系 本科、学士
1983年8月-1985年8月 国家民委西南民族学院化学系 助 教
1985年9月-1988年9月 华西医科大学药学院 研究生、硕士
1988年9月-1991年6月 中国科学院成都有机化学研究所 助研
1991年7月-1995年6月 日本国名古屋市立大学 研究生、博士
1995年7月-1995年10月 中国科学院成都有机化学研究所 副研
1999年11月-2000年5月 香港大学化学系 访问教授
1995年11月至今 中国科学院成都有机化学研究所 研究员、博导
获奖情况:
1)2002年获四川省科技进步一等奖
2)1994年获四川省科技进步二等奖
3)1993-1995年度日本学术振兴会(JSPS)“博士生奖励金”
4)2000年“国家杰出青年基金”
5)2000年中国化学会“有机合成杰出青年奖”
6)2004年“四川省青年科技奖”
7)入选中国科学院“百人计划”
-
主页访问
3158
-
关注数
0
-
成果阅读
737
-
成果数
16
邓金根, Weiguo Liu, a, c Xin Cui, a Linfeng Cun, a Jun Wu, a Jin Zhu, a Jingen Deng, *a, c Qinghua Fan b
SYNLETT 2005, No.10, pp 1591-159517. 06. 205,-0001,():
-1年11月30日
Novel dendritic chiral vicinal diamine ligands have beensynthesized and a series of dendritic Ru(BINAP)(diamine) catalystswere developed for asymmetric hydrogenation of a variety ofsimple aryl ketones in good catalytic activity and high enantioselectivity,as well as facile catalyst recycling. An increase of enantioselectivitieswas obtained by using the dendritic catalysts comparedwith Noyori catalysts under the same conditions in the case ofseveral substrates. Meanwhile, a remarkable structural effect oncatalytic activity and enantioselectivity, as well as reuse wasobserved.
chiral 1,, 2-diamine,, dendritic ligand,, ruthenium complex,, asymmetric hydrogenation
-
45浏览
-
0点赞
-
0收藏
-
0分享
-
299下载
-
0评论
-
引用
邓金根, Xiaoxia Suin, a, b Shuangjun Wang, a Shangjin Sun, a Jin Zhu, a Jingen Deng*a, b
Synlett 2005, No.18, 2776-2780,-0001,():
-1年11月30日
An efficient and straightforward method has been developedfor the preparation of enantiomerically enriched C2-symmetricalvicinal diamines via the addition of organometallic reagents to achiral bisimine, which gives access to a variety of optically purearomatic and aliphatic C2-symmetrical vicinal diamines in highyields. The 'Cram–Davis'open transition state model is proposed torationalize the observed stereoselectivities for the addition oforganolithium reagents to the bisimine.
chiral 1,, 2-diamine,, chiral bisimine,, asymmetric addition,, organometallic reagents,, asymmetric allylation
-
70浏览
-
0点赞
-
0收藏
-
0分享
-
478下载
-
0评论
-
引用
邓金根, Dong Xue, †, ‡ Ying-Chun Chen, *, § Qi-Wei Wang, † Ling-Feng Cun, † Jin Zhu, † and Jin-Gen Deng*, ‡
Org. Lett., Vol. 7, No.23, 2005,-0001,():
-1年11月30日
The first organocatalytic and asymmetric direct vinylogous Michael reaction that employs the electron-deficient vinyl malononitriles as the nucleophilic species has been reported. The novel transformations exhibit exclusive
-
60浏览
-
0点赞
-
0收藏
-
0分享
-
312下载
-
0评论
-
引用
邓金根, Hong-wu Xu, a, c Qi-wei Wang, a Jin Zhu, c Jin-gen Deng, *a, c Lin-feng Cun, a Xin Cui, a Jun Wu, a Xin-liang Xu b and Yu-liang Wu b
Org Biomol, Chem, 2005, 3, 4227-4243,-0001,():
-1年11月30日
Herein we present a new example of coordination-mediated resolution of racemic acids by a chiral acid. The reaction of copper(II) acetate monohydrate, optically pure O,O-dibenzoyltartaric acid (DBTA) and racemic a-bromo-2-chlorophenylacetic acid (HL1) in acetonitrile solution afforded a binuclear copper(II) complex with D-DBTA dianion, a-bromo-2-chlorophenylacetate and acetate as ligands. After decomposition of the complex with acid, the optically active acid ((R)-HL1) was obtained. Similarly, a-bromo-2-fluorophenylacetic acid (HL2), a-bromo-2-bromophenylacetic acid (HL3), a-chloro-2-chlorophenylacetic acid (HL4), a-chloro-2-fluorophenylacetic acid (HL5), a-bromophenylacetic acid (HL6), a-bromo-4-chlorophenylacetic acid (HL7), 2-bromopropionic acid (HL8) and 2-chloropropionic acid (HL9) were resolved by the same method. Satisfactory results were obtained for HL2 to HL5. For HL6 and HL7, only racemic acids were obtained. For the two a-halo aliphatic acids (HL8 and HL9), poor enantioselectivity was obtained. It is more interesting that three acids (HL1, HL2 and HL3) could spontaneously racemize in acetonitrile solution, which resulted in crystallization-induced dynamic resolution (CIDR) with greater than 50% yield.
-
61浏览
-
0点赞
-
0收藏
-
0分享
-
176下载
-
0评论
-
引用
邓金根, Fei Wang, †, ‡ Hui Liu, † Linfeng Cun, † Jin Zhu, *, § Jingen Deng, ‡ and Yaozhong Jiang†
J. Org. Chem. 2005, 70, 9424-9429,-0001,():
-1年11月30日
Asymmetric transfer hydrogenation of ketones, especially R-bromomethyl aromatic ketones,catalyzed by unmodified, hydrophobic transition metal-amido complexes (TsDPEN-M), wasperformed successfully with significant enhancement of activity, chemoselectivity, and enantioselectivity(up to 99% ee) in aqueous media containing micelles and vesicles. The hydrophobiccatalyst, embedded in micelles constructed from the surfactant cetyltrimethylammonium bromide(CTAB), could be separated from the organic phase along with the products and was recycled forat least six times.
-
67浏览
-
0点赞
-
0收藏
-
0分享
-
160下载
-
0评论
-
引用
邓金根, Dong Xue, †, ‡ Ying-Chun Chen, § Xin Cui, † Qi-Wei Wang, † Jin Zhu, † and Jin-Gen Deng*, ‡
J. Org. Chem. 2005, 70, 3584-3591,-0001,():
-1年11月30日
It was found that the chemoselectivity could be completely switched from CdO to CdC bonds inthe transfer hydrogenation of activated R,
-
37浏览
-
0点赞
-
0收藏
-
0分享
-
51下载
-
0评论
-
引用
【期刊论文】Synthesis of Dendritic Catalysts and Application in Asymmetric Transfer Hydrogenation
邓金根, Ying-Chun Chen, *, † Tong-Fei Wu, ‡ Lin Jiang, † Jin-Gen Deng, ‡ Hui Liu, ‡ Jin Zhu, ‡ and Yao-Zhong Jiang‡
J. Org. Chem, Vol. 70, No.3, 2005,-0001,():
-1年11月30日
Key Laboratory of Asymmetric Synthesis & Chirotechnology of Sichuan Province and Union Laboratory of Asymmetric Synthesis, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China, and West China School of Pharmacy, Sichuan University, Chengdu 610041, China Fre
-
39浏览
-
0点赞
-
0收藏
-
0分享
-
59下载
-
0评论
-
引用
邓金根, Ying-Chun Chen, Dong Xue, Jin-Gen Deng, * Xin Cui, Jin Zhu and Yao-Zhong Jiang
Y.-C. Chen et al. /Tetrahedron Letters 45(2004)1555-1558,-0001,():
-1年11月30日
The asymmetric transfer hydrogenation of activated olefins with chiral ruthenium amido complexes (Noyori catalyst) using formic acid-triethylamine azeotrope as hydrogen source resulted in excellent yields and high enantioselectivities (up to 88.5%).
-
58浏览
-
0点赞
-
0收藏
-
0分享
-
197下载
-
0评论
-
引用
邓金根, Jian Liao, Xiaohua Peng, Juhua Zhang, Kaibei Yu, Xin Cui, Jin Zhu and Jingen Deng*
org Biomol, Chem, 2003, 1, 1089-1085,-0001,():
-1年11月30日
An effective resolving agent, (2S,3S)-di-O-(p-toluoyl) tartaric acid (4), was screened using a family' approach to yield direct resolution of (R)-terbutaline (1) with high optical purity and yield. Molecular recognition was studied by X-ray crystallographic analyses of the single crystals of the pair of diastereomeric salts. The more-soluble salt formed a sheet supramolecular structure, and the less-soluble salt formed a columnar supramolecular structure by enantiodifferentiating self-assembly. The water molecule plays an important role during optical resolution, and makes the supramolecular structure of the less-soluble salt more thermodynamically stable than that of the more-soluble salt. Solvent system has little influence on the resolution.
-
35浏览
-
0点赞
-
0收藏
-
0分享
-
92下载
-
0评论
-
引用
【期刊论文】Multiple Dendritic Catalysts for Asymmetric Transfer Hydrogenation
邓金根, Ying-Chun Chen, † Tong-Fei Wu, † Jin-Gen Deng, *, † Hui Liu, † Xin Cui, † Jin Zhu, † Yao-Zhong Jiang, † Michael C. K. Choi, ‡ and Albert S. C. Chan‡
J. Org. Chem. 2002, 67, 5301-5306,-0001,():
-1年11月30日
The first and second generation multiple dendritic ligands based on chiral diamine were synthesized in a convergent approach and were well-characterized by NMR and MS techniques. Their ruthenium complexes prepared in situ had good solubility in the reaction medium (azeotrope of formic acid and triethylamine) and demonstrated high catalytic activity and enantioselectivity comparable to monomeric catalysts in the asymmetric transfer hydrogenation of ketones and imines. Quantitative yields and for some cases a slightly higher enantioselectivity (up to 98.7% ee) were obtained in the dendritic catalysis. Considering the high local catalyst concentrations at the periphery, diones were tested for the possible synergic reactivity between catalytic units at the surface, while no apparent differences were noted.
-
40浏览
-
0点赞
-
0收藏
-
0分享
-
90下载
-
0评论
-
引用