张新荣
光谱分析的方法、仪器和应用研究
个性化签名
- 姓名:张新荣
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学术头衔:
博士生导师
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学科领域:
分析化学
- 研究兴趣:光谱分析的方法、仪器和应用研究
张新荣,男,1956年生。1982年本科毕业于陕西师大化学系,1997年在比利时根特大学获分析化学专业博士学位。现为清华大学教授,博士生导师,分析中心主任,化学系副主任。兼任《光谱学与光谱分析》杂志副主编,《分析化学》、《化学通报》、《大学化学》、《分析仪器》、《岩矿分析》等杂志的编委。是第7、8、9、10届国际发光光谱分析会议的科学委员会委员,第11届该国际会议在北京召开时担任主席。长期从事光谱分析的方法、仪器和应用研究,曾主持国家自然科学基金项目、科技部项目以及国际合作项目多项。发表论文愈百篇,半数以上发表在SCI刊物上。
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【期刊论文】ICP-MS-based competitive immunoassay for the determination of total thyroxin in human serum
张新荣, Chao Zhang a, Fengbo Wu b and Xinrong Zhang*a
J. Anal. At. Spectrom., 2002, 17, 1304-1307,-0001,():
-1年11月30日
To further expand the range of analytes that can be detected by using ICP-MS coupled with bioanalytical methods, we have employed a new separation system based on the highly active surface streptavidin and biotinylated monoclonal antibody (McAb) in a competitive immunoassay followed by ICP-MS detection. Specifically, we have demonstrated its application for the determination of total thyroxine (T4) in human serum using Eu31 as a label. In this method, streptavidin immobilized to the pre-coated bovine serum albumin (BSA)-biotin on the microwells showed a significantly higher binding capacity for the biotinylated anti-T4 monoclonal antibody. Total T4 was quantified by measuring the Eu31 intensity with ICP-MS after using 1% HNO3 to extract Eu31 from the bound fraction of the immunocomplex. The detection limit was 7.4ng mL-1 with a sample volume of 25
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【期刊论文】Safety Evaluation of Organoarsenical Species in Edible Porphyra from the China Sea
张新荣, CHAO WEI, † WEIHUA LI, † CHAO ZHANG, † MARIJN VAN HULLE, § RITA CORNELIS, § AND XINRONG ZHANG*, †
J. Agric. Food Chem. 2003, 51, 5176-5182,-0001,():
-1年11月30日
A study was carried out to determine arsenic species in Porphyra seaweed originating from the ChinaSea. Information about arsenic species in Porphyra was provided by HPLC-ICP-MS and ES-MSMS.The total arsenic concentrations of Porphyra samples from five different producing areas rangedfrom 2.1 to 21.6mg/kg. The analysis report also showed that arsenosugars were the only arsenicspecies that could be detected in all of the extracts of samples. Arsenosugar PO4 was the majorcompound in most samples (0.3-13.9mg/kg of dry weight), followed by arsenosugar OH (0.7-6.2mg/kg of dry weight). A further experiment was done to investigate the stability of arsenosugars inthe process of being heated. It was observed that the arsenosugars were stable during a short-termheating at 100℃. Their stability in human ingestion was also studied. A substantial increase ofdimethylarsinic acid (DMA) was detected in urine samples collected from six volunteers after theconsumption of this seaweed. The results obtained indicated that arsenosugars had been metabolizedto DMA, which is more toxic than arsenosugars. From this point of view, consumers should considerthe possible adverse effects of edible Porphyra on human health and choose those Porphyra havinglower arsenic concentrations.
Arsenic speciation, arsenosugars, edible algae
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张新荣, Chao Zhang a, Fengbo Wu b, Yanyan Zhang c, Xin Wang c and Xinrong Zhang*a
J. Anal. At. Spectrom., 2001, 16, 1393-1396,-0001,():
-1年11月30日
The novel coupling method based on the hyphenation of immunoreaction with ICP-MS was developed andapplied to the determination of thyroid-stimulating hormone (TSH) in human serum. In this system, TSH wasfirstly captured by anti-TSH monoclonal antibodies immobilized on a solid support. Biotinylated anti-TSHmonoclonal antibodies and Eu3z-labell3+-ed streptavidin were then added to form the complex, capturedantibody-TSH-biotinylated anti-TSH antibody-Eu3z-labelled streptavidin. After unbound reactants werewashed away, Eu3z bound to the complex was extracted by 1% HNO3 and measured by ICP-MS. The Eusignal was directly proportional to the serum TSH concentration. The limit of detection was 0.5 mIU L-1 andthe assay was linear up to 170mIU L-1. The within-run (n=6) and between-run (n=6) relative standarddeviations (RSD) for low, medium and high concentration standards did not exceed 10%. The TSH resultsobtained by this procedure correlated well with those obtained by radioimmunoassay (r2=0.9639).
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张新荣, Chao Zhang, †, Zhenyu Zhang, Binbing Yu, ‡, Jinjun Shi, † and Xinrong Zhang*
Anal. Chem. 2002, 74, 96-99,-0001,():
-1年11月30日
This paper describes the study of atomization of nanoparticlesby inductively coupled plasma mass spectrometry (ICPMS) and developes a novel nonisotopic immunoassayby coupling sandwich-type immunoreaction to ICPMS. The goat-anti-rabbit immunoglobulin G (IgG) labeled with colloidal gold nanoparticles served as ananalyte in ICPMS for the indirect measurement of rabbitanti-human IgG. Matrix effect studies showed the goldsignal was not sensitive to the organic matrix. A relativelygood correlation (r2=0.9528) between the proposedmethod and enzyme-linked immunosorbent assay hasbeen obtained. The method may have significant potentialas an important ICPMS-based nonisotopic immnoassaymethod for the simultaneous determination of biologicanalytes of interest by labeling different kinds of inorganicnanoparticles.
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张新荣, Yi Lv, †, Sichun Zhang, Guohong Liu, Minwen Huang, ‡ and Xinrong Zhang*
Anal. Chem. 2005, 77, 1518-1525,-0001,():
-1年11月30日
This paper describes a novel aerosol chemiluminescencebaseddetector, which can be coupled to liquid chromatographyfor the determination of the chemicals with weakoptical absorbance in the UV-visible region. This aerosolchemiluminescence (CL)-based detector, in which HPLCeffluent is converted to aerosol and then generated CLemission on the surface of porous alumina, is composedof three main processes: nebuliztion of HPLC effluent, CL emission on surface of porous alumina material, andoptical detection. To demonstrate the utility of the aerosolchemiluminescence detector, some compounds such saccharides, poly (ethylene glycol)s, amino acids, and steroidpharmaceuticals are determined by the present aerosolchemiluminescence detection method. Compared with anevaporative light scattering detector, the proposed detectorshows the following features: (a) extensive CL emissionson porous alumina by many compounds tested, which leads to the potential application for the determinationof volatile and nonvolatile chemicals with or withoutUV-visible absorbance; (b) a CL mechanism based on thecatalytic oxidation of analytes, not on the light scattering,which suggests the present detector be free from theinterference of the inorganic and nonvolatile mobile-phasemodifiers. The CL characteristics and effect of differentparameters, such as temperature and nebulizer gas flowrate, were also discussed in this paper. Furthermore, thisaerosol chemiluminescence-based detector was successfullyapplied to the determination of raffinose, glucose,sucrose, maltose, and r-lactose.
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张新荣, Guo hong Liu, †, Yong fa Zhu, Xin rong Zhang, *, † and Bo qing Xu‡
Anal. Chem. 2002, 74, 6279-6284,-0001,():
-1年11月30日
A novel method based on conversion of chlorinatedvolatile organic compounds (CVOCs) to chlorine using anew type of column packed with nanometer TiO2 coupledwith chemiluminescence (CL) has been developed fordetermination of them in workplace air. CVOCs areconverted to chlorine by nanometer TiO2 at 220℃. TheCl2 that is produced is selectively enriched on the columnand subsequently released from the column at 600℃. The Cl2 that is released is determined using a postcolumnCL detector. The CL intensity was linear with CCl4 in therange of 0.1-380 ppm, and the detection limit was 40ppb (S/N) 3). Higher sensitivity could be acquired byusing a larger volume of enrichment. A similar procedurecould be used for the determination of other CVOCs. CLintensities of CH2Cl2, CHCl3, and CCl4 at the sameconcentration increased in the order CH2Cl2<CHCl3<CCl4. The method has been successfully applied to thedetermination of CCl4 in workplace air, where 0.15-150ppm CCl4 would be detected. The possible mechanismfor the long lifetime of the column packed with nanometerTiO2 was tested using Raman spectrometer, X-ray powderdiffraction, transmission electron microscopy and X-rayphotoelectron spectroscopy. The results showed that thecolumn packed with nanometer TiO2 could be operatedin the reversible mode for determination of CVOCs underthe present conditions. The method would be potentiallyapplied to the analysis of other chlorinated compoundsin environment, such as persistent organic pollutants.
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【期刊论文】Development of a Gas Sensor Utilizing Chemiluminescence on Nanosized Titanium Dioxide
张新荣, Yongfa Zhu, Jinjun Shi, Zhenyu Zhang, Chao Zhang, and Xinrong Zhang*
Anal. Chem. 2002, 74, 120-124,-0001,():
-1年11月30日
A gas-sensing mode based on chemiluminescence generatedon the surface of nanosized materials is proposed inthe present work. Seven nanosized materials were tested, and chemiluminescence was detected from six of themduring the catalytic oxidation of organic vapors in air. The luminescence characteristics of ethanol and acetonevapors passing through the surface of TiO2 chosen werestudied with a chemiluminescence-based detection system.The linear range of chemiluminescence intensityversus concentration of organic compounds is 40-400µg/mL for ethanol and 20-200µg/mL for acetone dissolvedin water, respectively. X-ray powder diffraction andRaman spectrometry were used to investigate the changesin catalytic activity of TiO2 after a 60-h reaction at 380℃. The results showed that the carbon deposited on thesurface of TiO2, decreasing the catalytic activity, but canbe removed in air by controlling the temperature at 500℃ for 3h. Regenerability and no consumption of sensorsubstrate signify the long lifetime of the gas sensor.
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【期刊论文】A survey of arsenic species in chinese seafood
张新荣, Weihua Li a, b, Chao Wei a, Chao Zhang a, Marijn Van Hulle c, Rita Cornelis c, Xinrong Zhang a, *
Food and Chemical Toxicology 41 (2003) 1103-1110,-0001,():
-1年11月30日
In the present report, thirty different types of Chinese edible seafood, including brown algae, red algae, fish, crab, shrimp, mussels, oysters, and clams, which are very popular foodstuffs in the Chinese kitchen, were examined for their total content of As aswell as its different species. Total arsenic concentration in algae samples was 1.7-38.7
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张新荣, Zhenyu Zhang a, Ke Xua, Willy R.G. Baeyens b, Xinrong Zhang a, ∗
Analytica Chimica Acta 535 (2005) 145-152,-0001,():
-1年11月30日
When reductive gases pass over the surface of nanosized catalysts, a kind of chemiluminescence named cataluminescence (CTL) canbe generated due to the production of excited intermediates. Here we report the observation of an energy transfer process between excitedintermediates and the nanosized catalysts. The CTL is quenched when introducing Ho3+, Co2+ and Cu2+ into the catalyst, while new intensiveCTL peaks appear when the catalyst is doped with Eu3+ or Tb3+. Further study indicates that the new CTL peak on Eu3+-or Tb3+-dopedcatalyst originates from the luminescence of the doped ions, excited by the energy transferred from excited intermediates produced during thereaction. Based on this novel energy-transfer CTL (ETCTL), an ethanol sensor is developed with Eu3+-doped nanosized ZrO2 that is linear toethanol concentrations from 45 to 550 ppm, with the whole linear range lower than the lower limit of the previous CTL sensor. The ETCTLfrom Eu3+-doped in nanosized ZrO2 shows 72 times higher sensitivity than the CTL from excited intermediates in the sensor. High selectivityand stability are also obtained for this sensor. The results also indicate that the main factor limiting the sensitivity of CTL sensor on purecatalyst may be the inevitable energy quenching of excited intermediates with the catalyst, which is artfully utilized in the present work bythe introduction of Eu3+ that effectively absorbs this part of energy and transfers it into light energy.
Cataluminescence, Energy-transfer, Chemical sensors
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张新荣, Sichun Zhang, Chao Zhang, Zhi Xing, and Xinrong Zhang*
Clinical Chemistry 50: 7 1214-1221 (2004),-0001,():
-1年11月30日
Background: An inductively coupled plasma mass spectrometry (ICP-MS)-based immunoassay has been proposedindependently by Baranov et al. (Anal Chem2002; 74: 1629-36) and our group, but the applicability ofthis method for multianalyte analysis in clinical sampleshas not been fully illustrated. We developed adual-label immunoassay method for the simultaneousdetermination of β-fetoprotein (AFP) and free β-humanchorionic gonadotropin (hCGβ) in human serum.Methods: Monoclonal antibodies immobilized on microtiterplates captured AFP and hCGβ, which weredetected by use of Eu3+-labeled anti-AFP and Sm3+-labeled anti-hCGβmonoclonal antibodies. Eu3+andSm3+were dissociated from the immunocomplex withHNO3 solution (10mL/L) and delivered by peristalticpump to the ICP mass spectrometer.Results: The measurable ranges of AFP and hCG+were4.6-500 and 5.0-170 ug/L, respectively, with detectionlimits of 1.2 and 1.7ug/L (3SD above mean of zerocalibrator), respectively. The intraassay imprecision (CV) for AFP was 8.3%, 4.0%, and 2.7% at 16.3, 86, and 354ug/L, respectively, and the interassay CV was 10%, 5.7%, and 3.5%. For hCGβ, the intraassay CV was 5.4%, 6.4%, and 3.1%, respectively, at 10.5, 45.2, and 105ug/L, and the interassay CV was 7.2%, 8.0%, and 3.7%. Comparisonwith IRMAs for AFP and hCGβyielded correlationcoefficients (r2) of 0.97 and 0.95.Conclusions: Two proteins can be measured simultaneouslyby immunoassays using two rare earth elementaltags (Eu3+and Sm3+) and ICP-MS detection. Themultielement capability and the multiple potential elementallabels make ICP-MS attractive for multianalyteimmunoassays. Implementation of ICP-MS-linked immunoassaysmay be relatively straightforward becausethe labeling and immunoreaction procedures have beenwell developed for clinical time-resolved immunofluorometricassays.
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