冯年平
主要从事中药药剂学的教学和科研工作。
个性化签名
- 姓名:冯年平
- 目前身份:
- 担任导师情况:
- 学位:
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学术头衔:
博士生导师
- 职称:-
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学科领域:
药剂学
- 研究兴趣:主要从事中药药剂学的教学和科研工作。
冯年平,男,教授,博士生导师。 1997 年 6 月于中国药科大学获得理学博士学位, 1998 年 10 月至今在上海中医药大学工作,现任药剂教研室主任。主要从事中药药剂学的教学和科研工作。在国内外学术期刊发表论文 50 余篇,申请发明专利多项,主 / 参编教材和学术著作多部;任 The Open Complementary Medicine Journal 杂志编委, Journal of Controlled Release, International Journal of Pharmaceutics 和 Drug Development and Industrial Pharmacy 等 SCI 期刊审稿人。曾获上海市“曙光学者”荣誉称号( 2001 )、霍英东基金会全国高校青年教师奖( 2003 )、上海市科技进步二等奖( 2007 )、上海医学科技奖二等奖( 2008 )、中华中医药学会科学技术奖三等奖( 2008 )等奖励; 2008 年入选教育部新世纪优秀人才支持计划。
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成果阅读
268
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成果数
5
冯年平, 屠锡德
中国药科大学学科,1996(1):13-15,-0001,():
-1年11月30日
研制了盐酸拉贝洛尔缓释片,研究了其人体内药物动力学。缓释片体外可维持释药12h,释药行为可用Higuchi方程来描述,溶出速度常数为4.26min-1/2;其体内药动学过程符合一级吸收单室模型,药动学参数为:Ka=1.7lh-1,K=0.1248h-1,Gmax=61.93ng/ml,Tmax=1.89h,AUC0→∞=603.9g•h/ml。
盐酸拉贝洛尔, 缓释片, 药物动力学
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冯年平, Nian-Ping FENG, *, a Bin DI, a, b and Wen-Ying LIUb
Chem. Pharm. Bull. 53(8)978-983(2005),-0001,():
-1年11月30日
Shuang-Huang-Lian (SHL) is a traditional Chinese formula containing Flos lonicerae, Radix scutellariae (RS) and Fructus forsythiae, and is commonly used for treating acute upper respiratory tract infection, acute bronchitis and light pneumonia. The aim of the present study is to compare the metabolites of baicalin in rats when orally administered with SHL and Radix scutellariae, and try to explore the principle of SHL compatibility. By using LC-MSn and HPLC-DAD, the metabolites of baicalin were analyzed from bile, urine and feces of rats dosed with SHL and RS. Our results showed significant difference of baicalin metabolism between RS and SHL. However, baicalein was found to be the main metabolites of baicalin in intestinal tract after oral administration of RS and SHL, glucuronide, glucoside and methylated products were also found in rat urine after administration of either RS or SHL. Meanwhile, several sulphates were found in rat urine after RS administration, but not found after SHL. Among the metabolites of the SHL, potentially there existed a isomerized baicalin and methylated product: 5, 7-dihydroxy-6-methoxyisoflavone-7-O-β-glucopyranuronoside, but without unidentified metabolite M3. Baicalein-6-O-β-glucopyranuronoside-7-O-β-glucopyranuronoside and baicalein-6-O-β-glucose-7-O-β-glucopyranuronoside were first reported by this study. The major metabolites of baicalin of RS and SHL in rat bile were the same, including baicalin-6-O-β-glucopyranuronoside-7-O-β-glucopyranuronoside, baicalin-6-b-glucopyranuronoside and 6-O-methyl-baicalin-7-O-b -glucopyranuronoside. Moreover, baicalein-6-O-β-glucose-7-O-β-glucopyranuronoside was also first found in rat bile by this study. Although baicalin-6-O-sulfate-7-O-β-glucopyranuronoside was found in rat bile after RS administration, no sulphated products were found after oral administration of SHL. These differences of baicalin metabolism between RS and SHL indicated that compatibility of medicines could result in the differences of metabolites.
Radix scutellariae, Shuang-Huang-Lian (, SHL), , metabolism, rat, LC/, DAD/, MS, baicalin
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冯年平, NIANPING FENG, PEIYI WU, QI LI, YINGHAO MEI, SHUIPING SHI, JING YU, JIE XU, YING LIU, & YAN WANG
Journal of Drug Targeting, July 2008; 16(6): 479-485,-0001,():
-1年11月30日
The aim of the present study was to develop a polymeric delivery system for water-insoluble drug oridonin. Amphiphilic block copolymers, poly(1-caprolactone)-poly(ethylene glycol)-poly (1-caprolactone) (PCL-PEO-PCL), were synthesized by ring-opening polymerization of caprolactone initiated by the hydroxyl groups of poly(ethylene glycol)6000 (PEG-6000) with stannous octoate as catalyzer. Oridonin-loaded PCL-PEO-PCL copolymer nanoparticles (ORI-PCL-PEO-PCL-NPs) were prepared by the interfacial deposition method. The mean particle size of the drug-loaded nanoparticles was 97.5nm and the zeta potential was 225mV. The entrapment efficiency and actual drug loading of the nanoparticles were 87.52%
PCL-PEO-PCL, oridonin, nanoparticles, antitumor activity
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冯年平, 范广平, 吴春兰, 韩朝阳
世界科学技术——中药现代化★药物生产技术,2002(2):49-52,-0001,():
-1年11月30日
微波萃取技术是利用微波强烈的热效应和非热效应,具有选择性高、操作时问短、溶剂消耗量少、有效成分得率高、不产生噪音、适合于热不稳定成分且能在短时问内杀灭植物中的水解酶等优点,在中药提取中有良好的应用前景。
微波萃取, 中药
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冯年平, 狄斌, 刘文英
世界科学技术——中医药现代,2003(2):5-7,-0001,():
-1年11月30日
药物代谢过程是影响药物发挥作用及产生毒性的过程。中药的配伍变化会直接导致药效成分在体内的代谢发生变化。运用LC/MSn等现代分析技术手段进行中药复方代谢研究,对于中药现代化有重要意义:研究中药复方体内代谢特征,探索中药复方的作用机制和配伍原理;通过体内代谢过程研究,寻找新的治疗药物;为中药新型给药系统的研究开发提供依据。
药物代谢, 中药现代化
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