目的 研究中西医结合治疗中晚期新月体性肾炎的疗效 方法 采用随机、对照的方法对经肾穿刺确诊为中晚期新月体性肾炎的32例患音分为清热活血方组（16例）、西药对照组（16例） 两组患者除l例外均用甲基泼尼松龙冲击治疗后改泼尼松口服治疗，部分患音加用环磷酰胺或吗替麦考酚酯，对血红蛋白低于90g/L音予皮下注射促红细胞生成素清热活血方组患音，另以白花蛇舌草30g忍冬藤30g紫花地丁30g赤芍15g生地15g黄精15g党参30g丹参30g制大黄12g藿香12g等每日1剂水煎服观察治疗3个月后患者的肾功能、贫血等改善情况及所需免疫抑制剂的数量 结果 两组患者经治疗后肾功能均有改善，但以清热活血方组为好(P<0.0)5)；经治疗后两组患音的贫血得到部分纠正，两组间差异无显著性；清热活血方组患音所用糖皮质激素较西药对照组明显为少(P<0.05)；结论 中西医结合治疗新月体肾炎具有较好的疗效，且可减少糖皮质激素的用量

Objective: To summarize and analyze the therapeutic effect of Yiqi Huoxue Huashi Project for patients with membranous nephropathy. Methods: One hundred and seventy MN patients were divided into two groups. Seventynine patients in Chinese herb group were treated with “Yiqi Huoxue Huashi Project” alone. One hundred patients in the control group were treated with integrated Chinese-Western therapy (“Yiqi Huoxue Huashi Project”combining with Immuno-suppressive agents). Results: The total effective rate at 1, 2, 4-year was 90.20%, 91.43% and 92.86%, respectively. The complete remission rate for more than 4 years was 71.43%. “Yiqi Huoxue Huashi Project” reduced urinary protein excretion and increased plasma albumin level, without significant differences compared with control group. The analysis of 128 cases of nephrotic syndrome patients showed that the total effective rate in Chinese herbs group(49 cases) reached 85.71%, without significant difference compared with control group(79 cases) which reached 82.28% . Conclusion: The therapeutic effect of “Yiqi Huoxue Huashi Project” is definite, with low relapse rate and no side effect. Chinese herbs play an important role in the treatment of intractable nephrotic syndrome.

本文报道以益气健脾方剂治疗阳离子牛血清造成的家兔膜型肾炎模型，与对照组相比，可减少尿蛋白，提高血清白蛋白，降低α2、β球蛋白及胆固醇，肾小球基底膜之病理损害也明显减轻，并对中药的作用机理做了进一步探讨。