本文应用大鼠外周血G0期淋巴细胞核异常测试法对铬的诱变效应进行了研究。实验结果表明，不同价态铬具有不同的诱变性。与常用的短期致突变测试法的实验结果相一致，本方法作为环境诱变剂的短期初筛试验有推广应用的价值。

The micronucleus test and sister-chromatic exchange (SCE) test were used to research the antimutagenic effect of pine needle extract. The results showed that the mutagenic effect of cyclophosphamide (CP) was inhibited by the pine needle extract. The micronucleus frequencies (MNF) of mouse bone marrow and human lymphocytes from peripheral blood were decreased with the effect of the extract (the dose was 2000mg/kg or 5mg/ml); the frequency of SCE in human lymphocytes was also reduced significantly, which indicated that the MNF and the SCE frequencies were negatively correlated with the dose of pine needle extract (r=-0.9782, -0.9587, -0.9765, respectively). This suggested that the pine needle extract was an effective antimutagen and it is important to choose the proper doses of pine needle extract for antitumor effect.

Environmental pollution with organic compounds has increased at the city of Shenyang in the Northeast China due to the rapid development of petrochemical industry. Approximately several hundred thousand tons of wastewater were discharged into the Xi River per day. The water was seriously polluted, which affected adversely public health and industrial and aqricultural supplies. Epidemic disease investigation and animal test data show that some organic compounds have mutagenic effects. This paper presented the research of mutagenicity of concentrated organic pollutants and their active components in the Xi River by the mouse bone marrow micronucleus test.

Mutagenicity of surface water in Lake Taihu was monitored by genotoxicological methods. The goal is to determine the situation concerning the contamination by mutagens, their distribution in the lake, and the potential effect on public health. In this study, the micronucleus test of Vicia.faba root tip, a standard monitoring technique now in China, was carried out to make a preliminary screening of environmental mutagens in 39 representative sites of the lake. Highly significant differences in MCN permillage (average number of micronuclei per 1000 cells) and PI (pollution index) values were found among these sites. From the results, a rough distribution of the contamination could be obtained: mainly concentrated in the north-west area of the lake from several tributaries flowing into the lake. In order to provide further evidence, organic extracts from four entrances and one outlet of the five major tributaries were examined by the micronucleus test of human peripheral lymphocytes. The results were in accord with those of the micronucleus tests using Vicia faba. The tests also revealed that the intensity and mechanis m of the pollutants were diverse in the different sources.