A survey of the whole plant of Saussurea parviflora afforded three compounds 11,12,13-trihydroxy-4 (15), 8-eudesmadiene-9-one, eudesman-813,12-olide-l-O-13-D-glucoside and 113,313-dihydroxyursa-9(11), 12-diene-3-octadecanoate, as well as 13 known compounds. Their structures were elucidated on the basis of spectral evidence, especially by using NMR spectroscopic techniques. In addition, encelin exhibited effective antitumor activity on L02, SMMC-7721 and HO-8910 cells.

从假橐吾全草中分离得到四对新的(1/2，3/4，5/6，7/8)和一对已知的(9/10)8，9-开环艾里莫芬内酯型倍半萜。每一对均为C-8位差向异构体。它们的结构通过波谱方法阐明并通过酰化或酯化分离后得到证实。活性筛选实验表明，1/2和3/4具有细胞毒活性。

Chemical investigation of the roots of Ligularia sagitta has resulted in the characterization of six eremophilenolides 6β,8βdimethoxy-1Oβ-hydroxyeremophil-7(11)-en-12,8a-olide (1), 6βan-geloyloxy-1Oβ-hydroxy-8β-methoxyeremophil-7(11)-en-12,8a-olide (2), 6/3-(2'-methylbutanoyloxy)-10β-hydroxy-8β-methoxy-eremophil-7(11)-en-12,8a-olide (3), 6β-angeloyloxy-1Oβ-hydro-xy-8a-methoxyeremophil-7(11)-en-12,8β-olide (4), 6β-(2'me-thylbutanoyloxy)-10β-hydroxy-8a-methoxyeremophil-7(11)-en-12.8β-olide (5) and 8β. lOβ-dihvdroxv-6β-methoxveremoohil-7(ll)-en-12,8a-olide (6), together with one monoterpene (3R,4R,65)-3,6-dihydroxy-l-menthene (7), two triterpenes lupeoi (8) and ursolic acid (9), and β-sitosterol (10). The structures of five new constituents (1-5) were elucidated by spectroscopic methods including 2D-NMR experiments. The compounds 1, 5 and 7 showed antibacterial activity by being assayed against Staphylococcus aureus, Bacillus subtilis and Escherichia coll.

Verbascoside and rutin possess anti-cancer properties and are capable of repairing DNA damaged by oxygen radicals, acting as powerful antioxidants. Based on kinetic measurements and experiments on tumor cells, docking studies of the two ligand molecules with the receptor telomeric DNA fragments have been carried out. The docking calculations performed using JUMNA software showed that the both molecules can be docked into the minor groove of telomeric DNA and form complexes with suitable geometry for electron transfer between guanine radicaland ligands. The reaction mechanism via the electron transfer process is further confirmed through energy calculations for transition states using MOPAC 93 program. Complexes can be formed without major distortion of DNA structure and are further stabilized by the interaction of DNA with the saccharide side-groups. By comparing their energies, the difference of activities of the two compounds can be explained.

Two new acetylxylosides, ent-manool-13-O-β-D-2'-acetylxylopyranoside (1) and entmanool 13-O-β-D-2', 4'-diacetylxylopyranoside (2) were isolated from Aster veitchianus. Their structures were elucidated by spectroscopic methods.