BACKGROUND: Although a specific and satisfactory therapeutic method for vascular dementia(VD) has not been developed, it is important to prevent VD by effectively avoiding risk factors, prevnting cerebrovascular accident(CVA) or preventing the recurrence, development and complications in patients with CVA. Exploring the effective mechanism for VD treatment with electroacupuncture method is one of the hot is suse in the study of VD therapy. OBJECTIVE: To observe the effects of electroacupuncture on learning and memory abilities and the apoptosis of cerebral cells in rats with VD DESIGN: A randomized and controlled experimental study. SETTING: Acupuncture and Massage Vocational College and College of Basic Medical Sciences, Guangzhou University of Traditional Chinese Medicine. MATERIALS: Sixty female and male(half-half) healthy adult SD rats, weighing 200-250g, were provided by the Research Center of Laboratory Animals, Guangzhou University of Traditional Chinese Medicine. METHODS: VD model of four-vessel occlusion was made in healthy SD rats from the Experimental Animal Center, Guangzhou University of Traditional Chinese Medicine, Morris water maze tests were used for place navigation test and spatial probe test. The apoptosis of nerve cells in the cerebral cortex and hippocampus were also tested with TUNEL method. RESULTS: The escape time(Latency) of rats in model group(58.08

目的：从血液流变学角度探讨针刺廉泉穴为主结合舌尖梅花针点刺治疗脑卒中后失语的机制。方法：全部51例患者按随机单盲法分为观察组3O例，对照组2l例。观察组以针刺廉泉结合舌尖梅花针点刺；对照组以头皮针运动区、语言区I，Ⅱ，Ⅲ针刺，均以30 d为1个疗程。1个疗程后观察疗效。结果：观察组总有效率为97％(29／30)，治愈率为23％(7／30)；对照组21例，总有效率为76％ (16／21)，治愈率为5％ (1／21)，两组疗效差异有显著性意义(X=8．107，P<0．05)。观察组血液流变学各项指标，除血沉指数和红细胞硬化指数外，其余治疗前后均有显著性意义(P<0．Ol或P <0．05)；对照组患者红细胞聚集指数、血沉方程K与红细胞硬化指数在治疗前后差异有显著性意义(P <0．Ol或P<0．05)。并且观察组与对照组在全血黏度方面差异有显著性意义(P <0．05)：结论：针刺廉泉穴结合舌尖梅花针为主治疗脑卒中性失语症的临床疗效很显著，优于头皮针组。

目的：运用正电子发射型计算机断层显像(PET)技术，研究百会、水沟、神门针刺前后，血管性痴呆(VD)患者大脑皮层葡萄糖代谢的变化，从该穴组对脑功能成像的影响，分析其作用机制。方法：10例VD病人随机分为两组。A组治以针对偏瘫的常规穴位(手足三阳经为主)，B组加用百会、水沟、神门，治疗前后所有病人均接受PET检测。划定VD患者双侧额叶(眶回)、双侧顶叶、双侧颞叶(海马及海马旁回)、双侧枕叶为感兴趣区。分析各区葡萄糖代谢水平，并进行治疗前后的比较。结果：治疗组患者针刺治疗后，双侧额叶、健脑颞叶的葡萄糖代谢升高具有统计学意义；常规针刺组患者治疗后，健脑颞叶的代谢升高具有统计学意义。结论：初步表明，百会、水沟、神门治疗VD的机理，与其改善额叶、颞叶的葡萄糖代谢有关。

目的：运用脑功能成像技术，研究不同穴位针刺前后，血管性痴呆(VD)患者大脑皮层葡萄糖代谢的变化。方法：25例VD病人，随机分为5组。A组治以针对偏瘫的常规穴位(手足三阳经为主)，B组加用百会，C组加用水沟，D组加用神门，E组加用百会、水沟和神门。治疗前后，所有病人均接受正电子发射型计算机断层显像(PET)检测。划定VD患者双侧额叶(眶回)、双侧顶叶、双侧颞叶(海马及海马旁回)、双侧枕叶、双侧丘脑、双侧豆状核、双侧尾核、双侧扣带回、双侧小脑为感兴趣区。结果：针刺偏瘫的常规穴位，豆状核和颞叶葡萄糖代谢升高；针刺百会穴额叶、颞叶和豆状核葡萄糖代谢升高，针刺水沟穴则额叶、丘脑和豆状核升高，针刺神门穴顶叶和豆状核升高，同时针刺三穴，额叶、颞叶、丘脑和豆状核等不同脑区葡萄糖代谢升高。结论：百会、水沟、神门对不同脑功能区的葡萄糖代谢产生不同的影响，在脑区有着不同的作用侧重。