中国科技论文在线

上传时间

2005年03月07日

【期刊论文】Synthetic Studies of the HIV-1 Protease Inhibitive Didemnaketals: Stereocontrolled Synthetic Approach to the Key Mother Spiroketals

涂永强， Yan Xing Jia， †， Bin Wu， Xin Li， Shi Kuo Ren， Yong Qiang Tu， *， Albert S. C. Chan， ‡， and William Kitching§

Org. Lett., Vol. 3, No 6, 2001，-0001，（）：

-1年11月30日

摘要

The stereocontrolled synthesis of (2S,4R,6R,8S,10S,1

31浏览
0点赞
0收藏
0分享
232下载
0

引用

上传时间

2005年03月07日

【期刊论文】Lewis Acid Promoted Highly Stereoselective Rearrangement of 2,3-Aziridino Alcohols: A New Efficient Approach to

涂永强， Bao Min Wang， Zhen Lei Song， Chun An Fan， Yong Qiang Tu， *， and Yian Shi†

Org. Lett., Vol. 4, No.3, 2002，-0001，（）：

-1年11月30日

摘要

A new Lewis acid promoted rearrangement reaction of 2,3-aziridino alcohols was discovered, which involved the highly stereoselective construction of a diastereogenic quaternary carbon center and efficient formation of

37浏览
0点赞
0收藏
0分享
221下载
0

引用

上传时间

2005年03月07日

【期刊论文】Rapid and Efficient Microwave-Assisted Amination of Electron-Rich Aryl Halides without a Transition-Metal Catalyst

涂永强， Lei Shi， Min Wang， Chun-An Fan， Fu-Min Zhang， and Yong-Qiang Tu*

Org. Lett., Vol. 5, No.19, 2003，-0001，（）：

-1年11月30日

摘要

A rapid and direct amination of aryl halides has been developed in good to high yields under microwave irradiation without a transition-metal catalyst. This reaction is a particularly powerful method for the coupling of electron-rich aryl halides with various amines. In some cases, the excellent regioselectivity could be observed, which facilitated the preparation of meta-substituted anilines from ortho- or para-substituted phenylhalides. In addition, a mechanism via the interesting benzyne intermediate has been proposed.

42浏览
0点赞
0收藏
0分享
320下载
0

引用

上传时间

2005年03月07日

【期刊论文】A General Efficient Strategy for cis-3a-Aryloctahydroindole Alkaloids via Stereocontrolled ZnBr2-Catalyzed Rearrangement of 2,3-Aziridino Alcohols

涂永强， Zhen Lei Song， Bao Min Wang， Yong Qiang Tu， *， Chun An Fan， and Shu Yu Zhang

Org. Lett., Vol. 5, No.13, 2003，-0001，（）：

-1年11月30日

摘要

A short and general approach to the cis-3a-aryloctahydroindole alkaloids has been developed on the basis of a key stereocontrolled ZnBr2-catalyzed rearrangement of 2,3-aziridino alcohols. Two representative members, (

54浏览
0点赞
0收藏
0分享
185下载
0

引用

上传时间

2005年03月07日

【期刊论文】Microwave-Promoted Three-Component Coupling of Aldehyde, Alkyne, and Amine via C-H Activation Catalyzed by Copper in Water

涂永强， Lei Shi， Yong-Qiang Tu， *， Min Wang， Fu-Min Zhang， and Chun-An Fan

Org. Lett., Vol. 6, No.6, 2004，-0001，（）：

-1年11月30日

摘要

An efficient three-component coupling of aldehyde, alkyne, and amine to generate propargylamines has been effected under microwave irradiation in water using only CuI catalyst without the noble metal cocatalyst. This method has proved to be applicable to a wide range of substrates. In addition, the preliminary experiment using (S)-proline methyl ester as a chiral source demonstrated that it could be developed to be a direct and highly diastereoselective method for construction of chiral propargylamines.

42浏览
0点赞
0收藏
0分享
481下载
0

引用