The prevalence of HIV/AIDS infection has increased greatly in China. In order to strengthen the cooperation from All fields to improve efforts in preventing HIV/AIDS transmission in China, This paper has been put forward. Based on more than 25 previous publications and desk studies, this paper clarified the relationships between the commerical sex Activities and the transmission of HIV/AIDS. Although the probability of HIV infection through sex intercourse is lower than the other routes in China, the major way of infection among the HIV positives is still through sexual contacts in the world, which accounts for 70% in the world. Heterosexual transmission would still be the major route of HIV transmission pattern in the future. This paper reviewed the ongoing progress, achievements as well as the shortages and weakness on HIV prevention research and interventions, such As the methodology used in the research field to obtain the effective and valid data And information. Different kinds of theories and models are mentioned in view of theoretical guidance.