中国科技论文在线

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2007年06月14日

【期刊论文】The elimination of diazepam in Chinese subjects is dependent on the mephenytoin oxidation phenotype

周宏灏

，-0001，（）：

-1年11月30日

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2007年06月14日

【期刊论文】Stereoselective disposition of carvedilol is determined by CYP2D6

周宏灏

，-0001，（）：

-1年11月30日

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2007年06月14日

【期刊论文】Induction of polymorphic4`-hydroxylation of S-mephenytoin by rifampicin

周宏灏

，-0001，（）：

-1年11月30日

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2005年01月19日

【期刊论文】Plasma caffeine metabolite ratio (17X/137X) in vivo associated with G-2964A and C734A polymorphisms of human CYP1A2

周宏灏， Xing-Mei Han a， Dong-Sheng Ou-Yang a， Pei-Xin Lu b， Chang-Hong Jiang a， Yan Shu a， Xiao-Ping Chen a， Zhi-Rong Tan a and Hong-Hao Zhou a

Pharmacogenetics 2001, 11: 429-435，-0001，（）：

-1年11月30日

摘要

Either G-2964 or A734 in the human CYP1A2 gene was con

CYP1A2,， 17X/， 137X,， phenotype,， genotype,， polymorphism

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2005年01月19日

【期刊论文】Differences in the Incidence of the CYP2C19 Polymorphism Affecting the S-Mephenytoin Phenotype in Chinese Han and Bai Populations and Identification of a New Rare CYP2C19 Mutant Allele1

周宏灏， ZHOU-SHENG XIAO， JOYCE A. GOLDSTEIN， HONG-GUANG XIE， JOYCE BLAISDELL， WEI WANG， CHANG-HONG JIANG， FENG-XIANG YAN， NAN HE， SONG-LING HUANG， ZHEN-HUA XU and HONG-HAO ZHOU

Printed in U.S.A.281: 604-609, 1997，-0001，（）：

-1年11月30日

摘要

The incidence of the S-mephenytoin polymorphism was compared in two Chinese ethnic groups, Han (n=101) and Bai (n=202) by phenotype and genotype analysis. The frequency of poor metabolizers (PMs) in Han vs. Bai subjects was 19.8% vs. 13.4%. Han subjects had a higher frequency of the mutant CYP2C19m1 allele (0.366 vs. 0.257, P＜.01) and a lower frequency of the wild-type allele (0.559 vs. 0.688, P＜.01) than Bai subjects, which is consistent with the difference in the frequencies of PMs between the two ethnic groups. This results in a lower percentage of homozygous wild-type extensive metabolizers of mephenytoin (EMs) in Han subjects than in Bai subjects (40% vs. 59%, P=.005). Therefore, Han subjects may be more susceptible than Bai subjects to the drugs metabolized by the CYP2C19 enzyme. Ratios of urinary S/R-mephenytoin in homozygous EMs were lower than those of heterozygous EMs for both Han and Bai subjects, which shows a gene-dosage effect. Genotype analysis identified all but one PM as homozygous or heterozygous for the two known mutant CYP2C19m1 and/or CYP2C19m2 alleles. A single Bai PM outlier was shown to be heterozygous for CYP2C19m1 and a new mutant CYP2C19 allele containing a single amino acid change of Arg4333Trp433. A genotyping test demonstrated that only this one individual carried this rare allele (frequency of 0.0025 in Bai subjects).

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