中国科技论文在线

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2005年03月04日

【期刊论文】Evidence for association between single nucleotide polymorphisms in T complex protein 1 gene and schizophrenia in the Chinese Han population

贺林， M S Yang， L Yu， T W Guo， S M Zhu， H J Liu， Y Y Shi， N-F Gu， G Y Feng， L He

J Med Genet 2004; 000: 1-6.，-0001，（）：

-1年11月30日

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2005年03月04日

【期刊论文】Family-based association studies of COMT gene polymorphisms and schizophrenia in the Chinese population

贺林， JB Fan，， WY Chen， JX Tang， S Li， NF Gu， GY Feng， G Breen， D St Clair and L He

Molecular Psychiatry (2002) 7, 446-447，-0001，（）：

-1年11月30日

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2005年03月04日

【期刊论文】A Gene Locus Responsible for Dyschromatosis Symmetrica Hereditaria (DSH) Maps to Chromosome 6q24.2-q25.2

贺林， Qing-he Xing，， * Ming-tai Wang， * Xiang-dong Chen， Guo-yin Feng， Hong-yun Ji， Jian-dong Yang， Jian-jun Gao， Wei Qin， Xue-qing Qian， Sheng-nan Wu， and Lin He

Am. J. Hum. Genet. 73: 000-000, 2003，-0001，（）：

-1年11月30日

摘要

Dyschromatosis symmetrica hereditaria (DSH) is a hereditary skin disease characterized by the presence of hyperpigmented and hypopigmented macules on extremities and face. The gene, or even its chromosomal location, for DSH has not yet been identified. In this study, two Chinese families with DSH were identified and subjected to a genomewide screen for linkage analysis. Two-point linkage analysis for pedigree A (maximum LOD score [Zmax]p 7.28 at recombination fraction [v] p 0.00) and pedigree B (Zmax p 2.41 at v p 0.00) mapped the locus for DSH in the two families to chromosome 6q. Subsequent multipoint analysis of the two families also provided additional support for the DSH gene being located within the region 6q24.2-q25.2, with Zmax p 10.64. Haplotype analysis confined the locus within an interval of 10.2Mbp, flanked by markers D6S1703 and D6S1708. The two families had no identical haplotype within the defined region, which suggests that the two families were different in origin. Further work on identification of the gene for DSH will open new avenues to exploration of the genetics of pigmentation.