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刘传勇, Chuan Yong Liu*, Dong Ping Xie, Ke Jing Liu, Yu Qin Zhou, Jing Zhang Liu
Brain Research 1032(2005)116-122,-0001,():
-1年11月30日
Our recent study indicated that, in the dorsal motor nucleus of the vagus (DMV), the N-methyl-d-aspartic acid (NMDA) receptor–nitric oxide (NO)-cGMP pathway participated in the regulation of gallbladder motility in rabbits. Oxytocin (OT) is involved as a neurotransmitter in autonomic regulation. The aim of the present experiments is to investigate the effect of OT microinjected into DMVon the gallbladder motility and the involvement of NMDA receptor-NO-cGMP pathway. A frog bladder connected with transducer was inserted into the gallbladder to record the gallbladder pressure. Microinjection of OT (10-50 nmol/L, 100 nl) dose dependently increased the strength of gallbladder phasic contraction. The excitatory effect of OT (10 nmol/L, 100 nl) was completely abolished by atosiban (10 mmol/L, 100 nl), the specific OT receptor antagonist, but was not influenced by [deamino-Pen1, O-Me-Tyr2,Arg8]-vasopressin (10 mmol/L, 100 nl), the V1 receptor antagonist. Pretreatment of ketamine (10 mmol/L, 100 nl), the NMDA receptor antagonist, suppressed the gallbladder motor response to OT; but pretreatment of 6-Cyaon-7-Nitroquinoxaline-2,3-(1H,4H)-Dione (CNQX; 10 mmol/L, 100 nl), the non-NMDA receptor antagonist, did not affect it. Pretreatment of l-NAME (10 mmol/L, 100 nl), the nitric oxide synthase (NOS) inhibitor, or methyl blue (10 mmol/L, 100 nl), the guanylyl cyclase inhibitor, inhibited the excitatory effect of OT on gallbladder motility. Hence, we deduced that the microinjection of OT into the DMVenhanced the gallbladder motility through binding specific OT receptors and activating the NMDA receptor-NO-cGMP pathway.
Oxytocin, Vasopressin receptors, Dorsal motor nucleus of the vagus, Gallbladder motility, Nitric oxide, N-methyl-d-aspartic acid receptor
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刘传勇
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刘传勇
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【期刊论文】Vagal modulation of intestinal afferent sensitivity to systemic LPS in the rat
刘传勇
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刘传勇
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